A5114910903- RNA modifications and cancer
- Plant biochemistry and biosynthesis
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- Plant tissue culture and regeneration
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Plant Gene Expression Analysis
- Transgenic Plants and Applications
- Traditional Chinese Medicine Analysis
- Phytochemicals and Antioxidant Activities
- Antimicrobial Peptides and Activities
- Genomics and Phylogenetic Studies
- Genetics and Neurodevelopmental Disorders
- Gene expression and cancer classification
- Histone Deacetylase Inhibitors Research
- Data Quality and Management
- Ubiquitin and proteasome pathways
- Biochemical and Structural Characterization
- Cancer-related Molecular Pathways
- Bacterial biofilms and quorum sensing
- Peroxisome Proliferator-Activated Receptors
- Antibiotic Resistance in Bacteria
- Phytochemistry and Biological Activities
- Genomics, phytochemicals, and oxidative stress
Soochow University
2025
Second Affiliated Hospital of Soochow University
2025
The Fifth People’s Hospital of Suzhou
2023-2025
Zhengzhou University
2020-2024
Henan Provincial Eye Hospital
2020-2024
Xinxiang Medical University
2024
Guangdong Academy of Medical Sciences
2024
Henan University
2022-2024
Zhengzhou People's Hospital
2013-2024
Henan Provincial People's Hospital
2020-2024
This study documents information on significant ethnomedicinal plants, which was collected from the traditional healers of three indigenous communities Bangladesh. The documented data were quantitatively analyzed for first time in this area. obtained through open-ended, semi-structured questionnaires. benefits, importance and coverage ethnomedicine expressed several quantitative indices including Informant Consensus Factor (ICF), Use Value (UV), Frequency Citation (FC), Relative (RFC)...
The development of an efficient protocol for successful hairy root induction by Agrobacterium rhizogenes is the key step toward in vitro culturing method mass production secondary metabolites. selection effective strain roots highly plant species dependent and must be determined empirically. Therefore, our goal was to investigate transformation efficiency different A. strains transgenic Fagopyrum tataricum 'Hokkai T10' cultivar; determine expression levels polypropanoid biosynthetic pathway...
Abstract Evolutionary radiation is a widely recognized mode of species diversification, but its underlying mechanisms have not been unambiguously resolved for species-rich cosmopolitan plant genera. In particular, it remains largely unknown how biological and environmental factors jointly driven occurrence in specific regions. Here, we use Rhododendron, the largest genus woody plants Northern Hemisphere, to investigate geographic climatic factors, as well functional traits, worked together...
We profiled and quantified glucosinolates, anthocyanins, carotenoids, other secondary metabolites in the skin flesh of pale green purple kohlrabis. Analysis these distinct kohlrabis revealed presence 8 12 2 7 phenylpropanoids. Glucosinolate contents varied among different parts types kohlrabi. Glucoerucin were 4-fold higher kohlrabi than those skin. Among cyanidin 3-(feruloyl)(sinapoyl) diglucoside-5-glucoside levels highest. Carotenoid much skins both The most phenylpropanoids ones....
In this study, we investigated the expression of seven MYB transcription factors (a total 17 genes that included Dof1.1, IQD1-1, MYB28, MYB29, MYB34, MYB51, and MYB122 their isoforms) involved in aliphatic indolic glucosinolate (GSL) biosynthesis analyzed GSL content different organs Chinese cabbage (Brassica rapassp. Pekinensis). MYB28 MYB29 stem was dramatically when compared with levels other organs. MYB122, IQD1-1 showed very low transcript among HPLC analysis glucosinolates (GSLs)...
Abstract Background Lycium chinense is well known in traditional Chinese herbal medicine for its medicinal value and composition, which have been widely studied decades. However, further research on limited due to the lack of transcriptome genomic information. Results The L. was constructed by using an Illumina HiSeq 2000 sequencing platform. All 56,526 unigenes with average length 611 nt N50 equaling 848 were generated from 58,192,350 total raw reads after filtering assembly. Unigenes...
Mulberry (Morus alba L.) is used in traditional Chinese medicine and the sole food source of silkworm. Here, 21 cDNAs encoding phenylpropanoid biosynthetic genes triterpene were isolated from mulberry. The expression levels involved these pathways accumulation rutin, betulin, betulinic acid, important secondary metabolites, investigated different plant organs. Most highly expressed leaves and/or fruit, most downregulated during fruit ripening. rutin was more than fivefold higher other...
Breast cancer is a common malignant tumor that has high tendency to metastasis the bone, leading cancer-induced bone pain (CIBP). Ghrelin can not only stimulate appetite and regulate energy balance, but also alleviate CIBP by inducing NPY expression. Octanoic acid (OA), type of medium chain fatty acids, provides an substrate promotes acylation ghrelin. However, it remains be elucidated whether OA-rich diet activating acyl-ghrelin/NPY pathway. First, thirty-six Sprague-Dawley rats were...
Atractylodes lancea (Thunb.) DC., named "Cangzhu" in China, which belongs to the Asteraceae family. In some countries of Southeast Asia (China, Thailand, Korea, Japan etc.) its rhizome, commonly called rhizoma atractylodis, is used treat many diseases as it contains a variety sesquiterpenoids and other components medicinal importance. Despite value, information sesquiterpenoid biosynthesis largely unknown. this study, we investigated transcriptome analysis different tissues non-model plant...
LRPPRC is a multifunctional protein involved in mitochondrial gene expression and function, cell cycle progression, tumorigenesis. We analyzed 253 paired cases of gastric cancer noncancerous regions six lines to demonstrate the importance for prediction prognosis cancer. Our results showed that tissues significantly higher than control tissue (P < 0.001). Patients with poorer overall survival rate those lower Multivariate analysis demonstrated lymph node metastasis (N), distant (M), TNM...
Anemone flaccida Fr. Shmidt (Ranunculaceae), commonly known as 'Di Wu' in China, is a perennial herb with limited distribution. The rhizome of A. has long been used to treat arthritis tradition China. Studies disclosed that the plant contains rich source triterpenoid saponins. However, little about saponins biosynthesis flaccida.In this study, we conducted tandem transcriptome and proteome profiling non-model medicinal plant, flaccida. Using Illumina HiSeq 2000 sequencing iTRAQ technique,...
In this brief, a class of robust output tracking problems for delayed Boolean control networks is considered under pinning control. First, we give the algebraic representation such networks, and then criterion derived from one-step reachability. Next, constructive program presented to design feedback controllers. With use these controllers, achievable. Further, an algorithm procedure are given identify time-optimal Finally, example used illustrate advantages innovation proposed approach.
Kuding tea are used as a traditional material and widely consumed in China. In this study, total saponins (TS) from water extract of was prepared by D101 macroporous resins analyzed UPLC-QTOF-MS/MS. Then the hypolipidemic effect TS investigated high-fat diet-induced hyperlipidemic mice. For comprehensive identification or characterization extract, 3 major Kudinoside A, F, D were isolated standards to investigate MS/MS fragmentation pattern. As result, 52 identified characterized tea....
To investigate the role of N6-methyladenosine (m6A) RNA modification in pathogenesis Graves' ophthalmopathy (GO). Surgically excised extraocular muscles from 7 patients with GO and 5 subjects without were used. The global m6A levels specimens determined using an methylation quantification kit. sequencing (RNA-seq) was used to analyze molecules involved regulation differential expression mRNAs between two groups (4 eyes, respectively). genes evaluated by real-time PCR. functional implications...
AbstractCIAPIN1, a newly identified apoptosis-related molecule, was found to be downregulated in human gastric cancer tissues as compared the matched adjacent nonneoplastic tissues. In this study, we investigated effect of CIAPIN1 on vitro and vivo proliferation cells. Ectopic expression knockdown cells SGC7901 MKN45 were achieved by transduction with recombinant adenoviruses expressing (Ad-CIAPIN1) CIAPIN1-specific small interference RNA (Ad-CIAPIN1siRNA). Gastric upregulated exhibited...
Abstract Blocking immune checkpoint CD47/SIRPα is a useful strategy to engineer macrophages for cancer immunotherapy. However, the roles of CD47-related noncoding RNA in regulating macrophage phagocytosis lung therapy remain unclear. This study aims investigate effects long (lncRNA) on via CD47 and proliferation non-small cell (NSCLC) TIPRL. Our results demonstrate that lncRNA KCTD21-AS1 increases NSCLC tissues associated with poor survival patients. its m6A modification by Mettl14 promote...
Prunella vulgaris L., commonly known as "self-heal" or "heal-all," is a perennial herb with long history of medicinal use. Phenylalanine ammonia-lyase (PAL), cinnamate 4-hydroxylase (C4H), and 4-coumarate:coenzyme-A (CoA) ligase (4CL) are important enzymes in the phenylpropanoid pathway accumulation rosmarinic acid (RA), which major secondary metabolite P. vulgaris. In this study, we isolated cDNAs encoding PvPAL, PvC4H, Pv4CL from using rapid amplification cDNA ends polymerase chain...
Hairy roots were obtained after inoculating sterile young stems of Fagopyrum tataricum with Agrobacterium rhizogenes R1000. The established displayed two morphological phenotypes when cultured on hormone-free medium containing Murashige-Skoog salts and vitamins. thin phenotype had a higher growth rate than the thick phenotype. Further, phenolic compound content was that In terms their total dry weight, produced an almost double amount (-)-epigallocatechin as well more 51.5% caffeic acid, 65%...
The objective of this study is to investigate the association among polymorphisms XRCC1 gene, smoking, drinking, family history tumors, and risk colorectal cancer (CRC) in population Han nationality Jiangsu Province, China. A case–control 320 patients with CRC 350 cancer-free subjects as a control group was conducted. three polymorphic sites, codons 194, 280, 399, genes were analyzed by PCR-RFLP. We find that heavy smoking (>500 cigarettes per year) significantly increased susceptibility (OR...
HBV infection is a global health burden. Covalently closed circular DNA (cccDNA) transcriptional regulation major cause of poor cure rates chronic hepatitis B (CHB) infection. Herein, we evaluated whether targeting host factors to achieve functional silencing cccDNA may represent novel strategy for the treatment infection.To evaluate effects Jumonji C domain-containing (JMJD2) protein subfamily JMJD2A-2D proteins on replication, used lentivirus-based RNA interference suppress expression...
The increasing of multidrug resistance in bacterial associated infections has impaired the current antimicrobial therapy and it forces search for other alternatives. In this study, we aimed to find vitro antibacterial activity seed coat Trachycarpus fortunei against a panel clinically important species. Ethanolic extracts target tissues were fractionated through macro porous resin by column chromatography, using ethanol as an organic solvent with concentration gradient 0-100%, each along 20%...