A5053405334- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Milk Quality and Mastitis in Dairy Cows
- Effects of Environmental Stressors on Livestock
- Reproductive Physiology in Livestock
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Natural product bioactivities and synthesis
- Family Caregiving in Mental Illness
- Ruminant Nutrition and Digestive Physiology
- Nanoparticle-Based Drug Delivery
- Animal Nutrition and Physiology
- Nanoplatforms for cancer theranostics
- Lung Cancer Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Genetic Mapping and Diversity in Plants and Animals
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and biosynthesis
- NF-κB Signaling Pathways
- Epigenetics and DNA Methylation
- Livestock Farming and Management
Binzhou University
2022-2025
Binzhou Medical University
2022-2025
Yangzhou University
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Peking Union Medical College Hospital
2024
Zunyi Medical University
2024
Affiliated Hospital of Guizhou Medical University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Nanostring Technologies (United States)
2023
Anhui University of Traditional Chinese Medicine
2020-2023
Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare but debilitating and life-threatening complication of acute embolism. Circular RNAs (circRNAs), presenting as covalently closed continuous loops, are RNA molecules with joined 3′- 5′-ends formed by back-splicing events. circRNAs may be significant biological to understand disease mechanisms identify biomarkers for diagnosis therapy. The aim this study was investigate the potential roles in CTEPH. Methods: Ten human...
Udder conformation traits are one of the most economic in dairy cows, greatly affecting animal health, milk production, and producer profitability industry. Genetic analysis udder structure scores have been developed Holstein cattle. In our research, we conducted a genome-wide association study for five traits, including anterior attachment (AUA), central suspensory ligament (CSL), posterior height (PUAH), width (PUAW), depth (UD), which fixed random model circulating probability unification...
Abstract: Cancer immunotherapy has emerged as a novel therapeutic approach against tumors, with immune checkpoint inhibitors (ICIs) making significant clinical practice. The traditional ICIs, PD-1 and PD-L1, augment the cytotoxic function of T cells through inhibition tumor evasion pathways, ultimately leading to initiation an antitumor response. However, implementation ICIs encounters obstacles stemming from existence immunosuppressive microenvironment inadequate infiltration CD8 + cells....
Holstein and Jersey cows, as excellent dairy breeds, have their own advantages in milk yield, quality, disease resistance, heat resistance. However, the adaptability rumen microbiome changes cows under stress are not clear. Therefore, main objective of this study was to compare differences tolerance ruminal stress. The experiment comprised a 7-day thermo-neutral (TN) period (HS) period. Five five with similar parity days were selected, fluid collected from them each. Compared TN period,...
Abstract We developed Standardised Minimum 3D Distance (SM3DD), an entirely cell segmentation/annotation-free approach to the analysis of spatial RNA datasets, using it compare lung tissue from 16 clinically normal individuals those 18 SARS-CoV-2 patients who died acute respiratory distress syndrome. coordinates were determined CosMx™ Spatial Molecular Imager (Bruker Biology, US). For each individual transcript location, we calculated three-dimensional distances nearest type, standardising...
Cottonseed meal (CSM), which is an unconventional protein material with abundant sources, high content, and a relatively cheap price, can be used in poultry diets. The aim of this study was to investigate the effects CSM on slaughter performance, meat quality chemical composition Jiangnan White goslings. A total 300 healthy 28-day-old male goslings were randomly divided into 5 treatments, 6 pens containing 10 geese each. Five isonitrogenous isocaloric experimental diets formulated such that...
MicroRNAs (miRNAs) play crucial roles in the development of various cancers. Here, we aimed to evaluate miR-138-5p lung cancer progression and value diagnosis.Quantitative real-time PCR was performed examine expressions smad nuclear interacting protein 1 (SNIP1) mRNA. The diagnostic analyzed using receiver operating characteristic (ROC) curve analysis, sensitivity, specificity. We explored effect on cell proliferation metastasis by CCK-8, colony formation, wound healing transwell assays....
Staphylococcus aureus intramammary infection is one of the most common causes chronic mastitis in dairy cows, whose development may be associated with epigenetic changes expression important host defense genes. This study aimed to construct a genome-wide DNA methylation profile mammary gland Chinese Holstein cows (n=3) following experimentally induced S. mastitis, and explore potential gene regulatory mechanisms affected by during mastitis. was extracted from aureus-positive aureus-negative...
Abstract PKM2 is an important regulator of the aerobic glycolysis that plays a vital role in cancer cell metabolic reprogramming. In general, Trib2 considered as “pseudokinase”, contributing to different kinds cancer. However, detailed roles TRIB2 regulating metabolism by remain unclear. This study demonstrated TRIB2, not has kinase activity directly phosphorylate at serine 37 cells. The elevated pSer37-PKM2 would subsequently promote dimers enter into nucleus and increase expression LDHA,...
The aim of this study was to assess the associations six single nucleotide polymorphisms (SNPs) three genes (DRD3, COMT, and SCL6A4) with type 2 diabetes mellitus (T2DM) in Southern Chinese.Five hundred ninety-five cases T2DM 725 healthy controls Han origin were recruited from hospitals Guangdong Province, China. Fasting serum concentrations markers interest (total cholesterol, triglyceride, plasma glucose, etc.) measured hospitals. SNP genotyping performed using a custom-by-design...
Background and Aim: With the prolonged survival time of patients with liver cancer, these families may face tremendous pressure development dilemmas that can easily lead to family adaptation crises. Correspondingly, crises adversely affect quality life members. Basing on McCubbin's resilience model stress, adjustment, adaptation, considering key factors affecting based a review literature, this study involved construction influencing in Chinese cancer patients, which was then verified...
Abstract Blocking immune checkpoint CD47/SIRPα is a useful strategy to engineer macrophages for cancer immunotherapy. However, the roles of CD47-related noncoding RNA in regulating macrophage phagocytosis lung therapy remain unclear. This study aims investigate effects long (lncRNA) on via CD47 and proliferation non-small cell (NSCLC) TIPRL. Our results demonstrate that lncRNA KCTD21-AS1 increases NSCLC tissues associated with poor survival patients. its m6A modification by Mettl14 promote...
In this study, circular RNAs (circRNAs) from Holstein cow mammary tissues were identified and compared between early lactation non-lactation. After analysis, 10,684 circRNAs identified, ranging 48 to 99,406 bp, the average size was 882 bp. The mainly distributed on chromosomes 1 11, 89.89% of belonged sense-overlapping circRNA. exons contained with ranged 47 concentrated 5. Compared non-lactating cows, 87 significantly differentially expressed in peak cows. There 68 upregulated 19...
Heat stress during late gestation could affect subsequent lactation performance, resulting in damage to the immune function, health, and growth performance of calves. This study aimed compare effects 33 days summer (Summer group, 70.15 < THI 74.28) with winter (Winter 57.55 67.25) on growth, hormones, oxidative stress, function Calves (Summer, n = 28; Winter, 23) were separated from cows immediately after birth fed 2 L colostrum within h 8−10 birth, respectively, weaned at 60 age. Bodyweight...
This study investigated the single nucleotide polymorphisms (SNPs) of Fatty acid desaturase 2 (FADS2) gene and further explored their genetic effects on conventionally collected milk production traits in Chinese Holstein cows using 18,264 test-day records 841 cows. One missense mutation c. 908 C > T (SNP site complementary DNA sequence), which caused an amino change from alanine to valine (294Ala Val), two 3’ untranslated region (UTR) SNPs, c.1571 G A c.2776 were finally identified. The...
Improving the quality of milk is a challenge for zootechnicians and dairy farms across globe. Long-chain acyl-CoA synthetase 1 (ACSL1) significant member long-chain gene family. It widely found in various organisms influences lactation performance cows, including fat percentage, protein percentage etc. Our study was aimed to investigate genetic effects single nucleotide polymorphisms (SNPs) ACSL1 on production traits. Twenty Chinese Holstein cows were randomly selected extract DNA from their...
The investigation aimed to explore the suitable amino acid (AA) supplementation pattern for goslings under low-protein diets. A total of 364 1-day-old male were randomly divided into 4 experimental groups, with 7 pens containing 13 each. groups control (CP, 18.55%), LPM 15.55% + major AA), LPA all and LPR AA content reduced proportionally control's CP). corn-soybean meal diets are formulated according ideal model goose its nutritional requirements. results indicated that ADG BW lowest, F: G...
Previous investigations have reported that microRNA-126 (miR-126) and its host gene, epidermal growth factor-like domain-containing protein 7 (EGFL7) are involved in lung cancer progression, suggesting EGFL7 miR-126 play a joint role development. In this study, we analyzed the methylation-associated regulation of non-small cell (NSCLC) further investigated association between EGFL7/miR-126 polymorphisms NSCLC susceptibility Han Chinese population. Based on our data, relative to those...