A5102003286- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- interferon and immune responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mycorrhizal Fungi and Plant Interactions
- Sperm and Testicular Function
- Fungal Biology and Applications
- Immunotherapy and Immune Responses
- Protease and Inhibitor Mechanisms
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- S100 Proteins and Annexins
- Adipokines, Inflammation, and Metabolic Diseases
- Heart Failure Treatment and Management
- Glycosylation and Glycoproteins Research
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Biomarkers in Disease Prognosis
- Ovarian function and disorders
- Sepsis Diagnosis and Treatment
- Phytochemistry and Bioactivity Studies
- Proteoglycans and glycosaminoglycans research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Growth Hormone and Insulin-like Growth Factors
- Entomopathogenic Microorganisms in Pest Control
Tianjin Academy of Agricultural Sciences
2019-2025
Dalian University
2025
Dalian University of Technology
2025
Central South University
2018-2024
Xiangya Hospital Central South University
2018-2024
Guizhou University
2023-2024
Jilin Agricultural University
2019-2024
University of Colorado Anschutz Medical Campus
2019-2023
Hangzhou Medical College
2023
Zhejiang Provincial People's Hospital
2023
Noradrenergic signaling sensitizes pathological GSK3β/tau activation to nanomolar Aβ.
Most platelet membrane proteins are modified by mucin-type core 1-derived glycans (O-glycans). However, the biological importance of O-glycans in clearance is unclear. Here, we generated mice with a hematopoietic cell-specific loss (HC C1galt1-/- ). These lack on platelets and exhibit reduced peripheral numbers. Platelets from HC show levels α-2,3-linked sialic acids increased accumulation liver relative to wild-type platelets. The preferential was lacking hepatic asialoglycoprotein receptor...
Purpose: The present study aimed to clarify the potential predictive significance of Systemic immune-inflammation index (SII) in assessing poor prognosis critically ill patients with congestive heart failure (CHF). Methods: Detailed clinical data were extracted from Multiparameter Intelligent Monitoring Intensive Care III database after gaining access and building local platform. 30- 90-day hospital all-cause mortalities patient was primary outcome, readmission rate occurrence major...
Neutrophil recruitment, mediated by β2 integrins, combats pyogenic infections but also plays a key role in ischemia–reperfusion injury and other inflammatory disorders. Talin induces allosteric rearrangements integrins that increase affinity for ligands (activation). links to actin proteins enable formation of adhesions. Structural studies have identified talin1 mutant (L325R) perturbs activation without impairing talin’s capacity link proteins. Here, we found mice engineered express only...
Leukocytes roll on P-selectin after its mobilization from secretory granules to the surfaces of platelets and endothelial cells. Tumor necrosis factor (TNF), IL-1β, lipopolysaccharide increase synthesis in murine but not human To explore physiological significance this difference gene regulation, we made transgenic mice bearing Selp crossed them with lacking (Selp−/−). The constitutively expressed platelets, cells, macrophages. mediated comparable neutrophil migration into inflamed...
Abstract Previously we have shown that transcription factor Foxp1 plays an essential role in maintaining naive T cell quiescence; the absence of Foxp1, mature CD8+ cells proliferate direct response to homeostatic cytokine IL-7. In this study, report deletion leads enhanced activation PI3K/Akt/mammalian target rapamycin signaling pathway and its downstream growth metabolism targets We found directly regulates PI3K interacting protein 1, a negative regulator PI3K. Additionally, results...
Abstract In the earliest phase of inflammation, histamine and other agonists rapidly mobilize P-selectin to apical membranes endothelial cells, where it initiates rolling adhesion flowing neutrophils. Clustering in clathrin-coated pits facilitates rolling. Inflammatory cytokines typically signal by regulating gene transcription over a period hours. We found that neutrophils on secreted cytokine oncostatin M (OSM). The released OSM triggered signals through glycoprotein 130 (gp130)–containing...
Abstract The relationship between sarcopenia and the long‐term risk of atrial fibrillation (AF) remains unclear. This study recruited a large prospective Caucasian cohort from UK Biobank. Participants were assessed at baseline with handgrip strength muscle mass categorized into groups non‐sarcopenia, probable sarcopenia, confirmed sarcopenia. Kaplan–Meier method Cox proportional hazards model used to explore association incidence AF. genetic predisposition AF was by polygenic score....
Tyro3, Axl and Mer (TAM) receptor tyrosine kinases triple knockout (TAM −/− ) mice are male infertile due to impaired spermatogenesis. However, the mechanism by which TAM receptors regulate spermatogenesis remains unclear. In this study, we demonstrate that testicular immune homeostasis was in mice. As development after onset of sexual maturity, germ cells were progressively degenerated. Macrophages lymphocytes infiltrated into testis as aged. Moreover, integrity blood–testis barrier...
A2A adenosine receptor (A2AAR) signaling negatively regulates inflammatory responses in many disease models, but the detailed mechanisms remain unclear. We used selective A2AAR agonist, ATL313, to examine how affects human and murine neutrophil adhesion under flow. Treating neutrophils with ATL313 inhibited selectin-induced, β2 integrin-dependent slow rolling chemokine-induced, arrest on ICAM-1. selectin-induced integrin extension, which supports rolling, chemokine-induced hybrid domain...
The testis is an immune privileged organ in which the tissue-specific cells have adopted effective innate functions against microbial pathogens. Toll-like receptors (TLRs) mediate response testis. current study demonstrates that melanoma differentiation-associated protein 5 (MDA5) and retinoic acid-inducible gene I (RIG-I) initiate testicular antiviral response. Both MDA5 RIG-I are expressed Leydig cells, also spermatids. Polyinosinic-polycytidylic acid [poly(I:C)], a common agonist of...
Circulating neutrophils must avoid premature activation to prevent tissue injury. The leukocyte adhesion receptor L-selectin forms bonds with P-selectin glycoprotein ligand-1 (PSGL-1) on other leukocytes and peripheral node addressin (PNAd) high endothelial venules. Mechanical forces can strengthen (catch) or weaken (slip) between biological molecules. How these mechanochemical processes influence function in vivo is unexplored. Here we show that mice expressing an mutant (N138G) have...
Abstract Viral infections of the epididymis may impair male fertility and spread sexually transmitted pathogens. The innate antiviral immune responses in have yet to be intensively investigated. This study found that mouse epididymal epithelial cells (EECs) constitutively express several viral sensors, including TLR3, retinoic acid–inducible gene I, DNA-dependent activator IFN regulatory factors. Other DNA p204 cGMP-AMP synthase, can induced by transfection synthetic HSV genomic (HSV60)....
Abstract Inspired by the strong adhesion properties of mussel byssus protein, this paper presents construction a multi‐scale TA‐APTES‐GO interfacial layer aimed at addressing inadequate CF/PPESK composites. XPS, Raman spectroscopy, and SEM confirmed that novel can enhance activity roughness CF surface, thereby promoting resin infiltration. Furthermore, exhibits modulus transition eliminates discrepancy between matrix, mitigates stress concentration. Mechanical property tests demonstrated...
This study aimed to identify the pathogen of oil palm (Elaeis guineensis) leaf spot disease in Hainan Province, China and examine effects environmental factors fungicide sensitivity on pathogen. The research confirmed that responsible for this novel was Colletotrichum siamense, marking first report China. Field observations revealed summer-onset symptoms with concomitant damage. demonstrated optimal growth at a temperature 30 °C pH 7.0, indicating its adaptability prevailing climatic...
Although wide range of viruses can infect adipose tissues, innate antiviral response cells has not been investigated. This study focused on system in mouse cells. Major virus sensors including Toll‐like receptor 3 (TLR3), melanoma differentiation‐associated antigen 5 (MDA5) and retinoic acid‐inducible gene I (RIG‐I) are constitutively expressed preadipocytes adipocytes. Poly(I:C), a common agonist TLR3, MDA5 RIG‐I, induced the expression type interferons (IFN‐α/β) two types through...
The mammalian testis is an immunoprivileged organ where male germ cell autoantigens are immunologically ignored. Both systemic immune tolerance to and local immunosuppressive milieu contribute the testicular privilege. Testicular immunosuppression has been intensively studied, but information on lacking. In present study, we aimed determine role of Axl Mer receptor tyrosine kinases in maintaining antigens using experimental autoimmune orchitis (EAO) model. double‐knockout (Axl −/− ) mice...
The mammalian testis is an immunoprivileged organ where local tissue-specific cells acquire effective innate immune function against invading microbial pathogens. present study demonstrated that mouse Leydig had antiviral activities in response to viral DNA challenge through p204 activation. sensor and its signaling adaptor stimulator of interferon (IFN) genes (STING) were constitutively expressed cells. Synthetic herpes simplex virus analog (HSV60), a agonist, induced the expression type I...
The aim of this study was to assess the associations six single nucleotide polymorphisms (SNPs) three genes (DRD3, COMT, and SCL6A4) with type 2 diabetes mellitus (T2DM) in Southern Chinese.Five hundred ninety-five cases T2DM 725 healthy controls Han origin were recruited from hospitals Guangdong Province, China. Fasting serum concentrations markers interest (total cholesterol, triglyceride, plasma glucose, etc.) measured hospitals. SNP genotyping performed using a custom-by-design...