A5100743004- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Cytomegalovirus and herpesvirus research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Diseases and Immunity
- Neuroendocrine regulation and behavior
- Child and Adolescent Psychosocial and Emotional Development
- Head and Neck Cancer Studies
- Inflammatory Myopathies and Dermatomyositis
- Respiratory Support and Mechanisms
- Immune cells in cancer
- Hepatitis C virus research
- Mast cells and histamine
- Liver Disease and Transplantation
- Inflammatory Biomarkers in Disease Prognosis
- Infectious Encephalopathies and Encephalitis
- Parkinson's Disease Mechanisms and Treatments
- Esophageal Cancer Research and Treatment
- Enterobacteriaceae and Cronobacter Research
- Child Development and Digital Technology
- Cancer, Lipids, and Metabolism
- Celiac Disease Research and Management
- Protein Degradation and Inhibitors
- Muscle Physiology and Disorders
- Health, Environment, Cognitive Aging
Chengdu Normal University
2023-2024
Shandong Normal University
2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Boston University
2023
First Affiliated Hospital of Kunming Medical University
2023
Kunming Medical University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2022
Guangxi Medical University
2022
Johnson Electric (China)
2022
Costunolide not only improved gastrointestinal dysfunction but also ameliorated depressive-like behaviors in mice with stress-induced irritable bowel syndrome.
Background Immunosuppression is common even in the early stage of severe sepsis. Interleukin-10 (IL-10) secretion and lymphocyte exhaustion are main features sepsis-induced immunosuppression. However, relationship between IL-10 still unclear. We investigated if IL-10/lymphocyte ratio (IL10LCR) were associated with mortality septic patients. Methods Adult patients sepsis admitted to ICU First Affiliated Hospital Guangzhou Medical University identified from October 2012 August 2013. Within 24...
High-grade serous ovarian cancer (HGSOC), with its high recurrence rates, urges for reasonable therapeutic strategies that can prolong overall survival. A tumor microenvironment (TME) discloses prognostic and prospective information on cancer, such as the expression level of PD-1 or PD-L1. However, in HGSOC, impact therapies aiming at these targets remains unsatisfying. Tumor-associated macrophages (TAMs) HGSOC make up a large part TMEs transform between diverse phenotypes under different...
Extracorporeal membrane oxygenation (ECMO) is increasingly being applied as life support for acute respiratory distress syndrome (ARDS) patients. However, the outcomes of this procedure have not yet been characterized in severe ARDS The aim study was to evaluate patients supported with ECMO and identify potential predictors mortality these A total 38 (aged 51.39±13.27 years, 32 males) who were treated specialized medical intensive care unit Guangzhou Institute Respiratory Diseases from July...
HBV infection is a global health burden. Covalently closed circular DNA (cccDNA) transcriptional regulation major cause of poor cure rates chronic hepatitis B (CHB) infection. Herein, we evaluated whether targeting host factors to achieve functional silencing cccDNA may represent novel strategy for the treatment infection.To evaluate effects Jumonji C domain-containing (JMJD2) protein subfamily JMJD2A-2D proteins on replication, used lentivirus-based RNA interference suppress expression...
<p id=p00005>Prosocial behaviour, that is, behaviour intended to benefit others, has been linked a variety of desirable traits, including positive relationships, better academic performance and lower levels antisocial behaviours. As such, the origins mechanisms underlying remarkable individual differences in prosocial are focus an increasing number studies, with numerous research consistently documenting important role parenting empathy. Notably, differentiating between cognitive emotional...
The present study was designed to ascertain whether lapatinib, a tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR), affects ovarian reserve and fertility potential in mouse model. Female C57BL/6 mice were treated with either vehicle or lapatinib (100 200 mg/kg/day orally) for 4 weeks, after which body weight, vaginal smears, follicle numbers, serum anti‑Müllerian hormone (AMH) levels mating outcomes analyzed assess the reproductive function. Slices from ovaries 4‑week‑old...
Abstract Background Primary biliary cirrhosis (PBC) is a liver specific chronic disease with unclear pathogenesis, especially for the early stage molecular events. The mitochondrion multi-functional organelle associated various diseases including PBC. purpose of this study was to discover alterations in mitochondria proteome using an PBC mouse model revealing possible pathogenesis mechanisms stages Methods Mouse constructed by consecutive administration poly I:C. Mitochondria models and...
Diffuse large B-cell lymphoma (DLBCL) is a common non-Hodgkin's lymphoma. R-CHOP protocol for long-term chemotherapy DLBCL patients. Long-term can lead to low immunity and increase the risk of opportunistic pathogen infections in immunocompromised patients.We report case coinfection with Pneumocystis jirovecii (P. jirovecii) Legionella pneumophila (L. pneumophila) patient DLBCL. The was 40-year-old female who diagnosed admitted due pulmonary infection. P. L. were detected her bronchoalveolar...
The risk of opportunistic fungal infections is high in immunocompromised patients. Penicillium genus common and diverse nature. However, it rarely causes infection humans. Here, we reported a case janthinellum pneumonia systemic lupus erythematosus (SLE) patient, the morphological characteristics P. were also described. patient was 64-year-old female. She had been diagnosed with SLE membranous nephritis 10 months previously. Her medications included methylprednisolone, cyclosporine,...
By Donnellan's account of definite descriptions, two uses are recognized: the denoting use and referential use. When clarifying relationship between uses, current paper attempts to argue that achieve does not amount effect language-related properties descriptions determined by constituent words syntactic rules should be abandoned, instead being a denial basic meaning linguistic expression, deviation caused from one merely suggests effects language produced multiple factors. In addition,...
<title>Abstract</title> <bold>Background:</bold> Cirrhosis is the end-stage liver fibrosis and leads to massive death worldwide. Interstitial lung abnormalities (ILAs) have received widespread attention because of their progression pulmonary mortality. This study aimed investigate whether presence ILAs associated with elevated mortality in patients cirrhosis. <bold>Methods: </bold>Patients diagnosed cirrhosis between August 2011 November 2023 were retrospectively included. Clinical data...
The impact of hepatitis B virus (HBV) infection status on liver metastasis nasopharyngeal carcinoma (NPC) has not been thoroughly elucidated to date. This study aimed determine how HBV influences NPC through the analysis clinical samples.A total 1,367 patients with pathologically diagnosed who received systemic treatment at Nanfang Hospital or Zhujiang between January 2005 and December 2015 were enrolled in this retrospective study. Based their status, these separated into four groups:...
Infertility is a public health concern worldwide. Asthenozoospermia common cause of male infertility and characterized by decreased motility. Sperm motility ensures that sperm migrate to complete fertilization. Macrophages are an essential component innate immunity in the female reproductive tract. Macrophage extracellular traps induced various microorganisms capture mediate clearance microorganisms. The relationship between macrophage unclear. human monocyte leukemia (THP-1) cells...