A5100394837- Reproductive Biology and Fertility
- Ovarian function and disorders
- Acute Lymphoblastic Leukemia research
- Sperm and Testicular Function
- Malaria Research and Control
- Ovarian cancer diagnosis and treatment
- Renal and related cancers
- Pluripotent Stem Cells Research
- Acute Myeloid Leukemia Research
- Ocular Surface and Contact Lens
- Maternal Mental Health During Pregnancy and Postpartum
- Streptococcal Infections and Treatments
- Childhood Cancer Survivors' Quality of Life
- Computational Drug Discovery Methods
- Chronic Lymphocytic Leukemia Research
- Tissue Engineering and Regenerative Medicine
- Occupational exposure and asthma
- Birth, Development, and Health
- Pancreatic function and diabetes
- Prenatal Screening and Diagnostics
- Antimicrobial Resistance in Staphylococcus
- Folate and B Vitamins Research
- Metabolism, Diabetes, and Cancer
- Glaucoma and retinal disorders
- Fatty Acid Research and Health
Guizhou Normal University
2024
Gansu Desert Control Research Institute
2024
Linyi People's Hospital
2024
Second Affiliated Hospital of Fujian Medical University
2022-2023
Fujian Medical University
2022-2023
Tongji Hospital
2020-2023
Huazhong University of Science and Technology
2020-2023
First Affiliated Hospital of Xiamen University
2016-2023
Yangzhou University
2023
Ministry of Education of the People's Republic of China
2022
Abstract This study was carried out to examine the participation of epidermal growth factor (EGF)‐like peptides in induction germinal vesicle breakdown (GVB) mouse cumulus cell‐enclosed oocytes (CEO). The EGF‐like peptide, amphiregulin (AR), dose‐dependently stimulated meiotic resumption CEO, but not denuded (DO) maintained arrest with 300 µM dbcAMP. EGF receptor (EGFR) kinase inhibitor, AG1478, blocked induced by FSH and AR had no effect DO. FSH‐induced maturation also suppressed antisera...
In many Lactobacillales species (i.e. lactic acid bacteria), peptidoglycan is decorated by polyrhamnose polysaccharides that are critical for cell envelope integrity and shape also represent key antigenic determinants. Despite the biological importance of these polysaccharides, their biosynthetic pathways have received limited attention. The important human pathogen, Streptococcus pyogenes, synthesizes a surface polymer, Lancefield group A carbohydrate (GAC). GAC covalently attached to...
Chlorine gas is considered a chemical threat agent that can cause acute lung injury. Studies in the early 20th century on war gases led Haber to postulate dose of an inhaled expressed as product concentration and exposure time leads constant toxicological effect (Haber’s Law). In present work, mice were exposed chlorine (100 ppm-h) delivered using different combinations (800 ppm/7.5 min, 400 ppm/15 200 ppm/30 100 ppm/60 min). Significant effects protocol survival evaluated 6 h after...
cAMP plays a critical role in the control of oocyte maturation, as high level maintains arrest at first meiotic prophase. Yet this study shows that pulsing meiotically arrested denuded oocytes (DO) with induces maturation through activation AMP-activated protein kinase (PRKA). Short-term (3 h) forskolin, an adenyl cyclase (AC) activator, increased cAMP, led to elevated AMP, and induced resumption compared continuously cultured medium or without forskolin. Western analysis showed germinal...
Artemisinin (ART) is an efficacious and safe anti-malarial drugs but has low oral bioavailability auto-induction profiles during multiple dosing. The pharmacokinetic disadvantages have been found to partially depend on the induction of cytochrome P-450 enzymes by ART resulted in therapeutic failure due insufficient drug levels. present study, therefore, investigated impacts chrysosplenetin (CHR), a polymethoxylated flavonoid from Artemisia annua, pharmacokinetics efficacy against Plasmodium...
Detailed characterization of the gene expression patterns in spermatogonia and primary spermatocytes is critical to understand processes which occur prior meiosis during normal spermatogenesis. The genome-wide profiles mouse type B were investigated using Solexa/Illumina digital (DGE) system, a tag based high-throughput transcriptome sequencing method, developmental early spermatogenesis systematically analyzed. Gene vary significantly between spermatocytes. functional analysis revealed that...
In this study we have examined the meiosis-inducing influence of adenosine analogs in mouse oocytes. When a varied group nucleosides and nucleotides were tested on overnight cultures hypoxanthine-arrested, cumulus cell-enclosed oocytes (CEO), halogenated nucleosides, but not native adenosine, exhibited significant capability. under variety conditions, meiotic induction by 8-bromo-adenosine (8-Br-Ado) second analog, methylmercaptopurine riboside (MMPR), was especially potent denuded (DO)...
Nlrp2 is a maternal effect gene specifically expressed by mouse ovaries; deletion of this from zygotes known to result in early embryonic arrest. In the present study, we identified FAF1 protein as specific binding partner NLRP2 both oocytes and preimplantation embryos. addition embryos, Faf1 mRNA were detected multiple tissues. proteins co-localized cytoplasm nucleus during development Co-immunoprecipitation assays used confirm interaction between proteins. Knockdown or interfered with...
Paclitaxel (PXL) is a chemotherapeutic agent widely used in solid tumors. However, whether PXL causes premature ovarian insufficiency women of reproductive age remains controversial. The aim the present study was to answer how and for long affects fertility, identify protective effect gonadotropin‑releasing hormone agonist (GnRHa) mice. A single dose administered 7‑week‑old female ICR Mice were treated with GnRHa 1 estrous cycle prior chemotherapy, another following chemotherapy. On days 1,...
Anxiety disorder has a high prevalence, and the risk of anxiety increases with age. Prenatal inflammation during key developmental timepoints can result in long-term changes phenotype, even over lifetime across generations. However, whether maternal exposure late gestation intergenerational transmission effects on age-related anxiety-like behaviors possible underlying mechanisms are largely unknown. Fatty acid binding protein 7 (FABP7) is critical hippocampal neurogenesis closely related to...
Our previous study revealed that the polymethoxy-flavonoids, as main components of Artemisia annua, could improve antimalarial activity Artemisinin. Here, we described isolation, elucidation, constituent analysis, flavonoids enrichment extracts A. annua. A total 20 compounds were isolated including a new sesquiterpene (compound 12) and five (1, 5, 6, 7, 15) afforded for first time from The elucidation eight may be useful phytochemical data chemical foundation further mechanism studies on...
Streptococcus pyogenes (Group A or GAS) is a haemolytic human pathogen associated with wide variety of infections ranging from minor skin and throat to life-threatening invasive diseases. The cell wall GAS consists peptidoglycan sacculus decorated carbohydrate comprising polyrhamnose backbone immunodominant N-acetylglucosamine side-chains. All genomes contain the spyBA operon, which encodes 35-amino-acid membrane protein SpyB, membrane-bound C3-like ADP-ribosyltransferase SpyA. In this study...
The present study was designed to ascertain whether lapatinib, a tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR), affects ovarian reserve and fertility potential in mouse model. Female C57BL/6 mice were treated with either vehicle or lapatinib (100 200 mg/kg/day orally) for 4 weeks, after which body weight, vaginal smears, follicle numbers, serum anti‑Müllerian hormone (AMH) levels mating outcomes analyzed assess the reproductive function. Slices from ovaries 4‑week‑old...