A5001006976- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Renal and related cancers
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pharmacogenetics and Drug Metabolism
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Periodontal Regeneration and Treatments
- Dental Implant Techniques and Outcomes
- RNA Research and Splicing
- Inhalation and Respiratory Drug Delivery
- Oral microbiology and periodontitis research
- Animal Genetics and Reproduction
- Respiratory and Cough-Related Research
- Wnt/β-catenin signaling in development and cancer
- Natural Antidiabetic Agents Studies
- Pluripotent Stem Cells Research
- Bone Tissue Engineering Materials
- Animal Virus Infections Studies
- Berberine and alkaloids research
- Electrospun Nanofibers in Biomedical Applications
- Reproductive Physiology in Livestock
- Plant tissue culture and regeneration
- Plant Pathogens and Fungal Diseases
- Microbial Inactivation Methods
Hainan University
2010-2025
Sanya University
2024
Tianjin haihe hospital
2022-2023
Tianjin University of Traditional Chinese Medicine
2019-2023
Gansu Agricultural University
2021-2022
Fujian Agriculture and Forestry University
2013-2019
Wannan Medical College
2019
Peking University
2018
Northwest A&F University
2012-2013
China University of Geosciences
2011
Maternal effect genes encode proteins that are produced during oogenesis and play an essential role early embryogenesis. Genetic ablation of such in oocytes can result female subfertility or infertility. Here we report a newly identified maternal gene, Nlrp2, which plays embryogenesis the mouse. Nlrp2 mRNAs their (∼118 KDa) expressed granulosa cells folliculogenesis. The transcripts show striking decline preimplantation embryos before zygotic genome activation, but remain present through to...
Idiopathic pulmonary fibrosis (IPF) is a serious and fatal inflammatory disease with an increasing incidence worldwide. The drugs nintedanib pirfenidone, are listed as conditionally recommended in the "Evidence-Based Guidelines for Diagnosis Treatment of Pulmonary Fibrosis". However, these two have many adverse reactions clinical application. Salvianolic acid B (Sal B), water-soluble component Salvia miltiorrhiza, could alleviate bleomycin-induced peroxidative stress damage, prevent or delay...
The selection of good quality oocytes is crucial for in vitro fertilization and somatic cloning. Brilliant cresyl blue (BCB) staining has been used from several mammalian species. However, the effects differential oocyte by BCB on nuclear reprogramming vivo development SCNT embryos are not well understood. Immature compact cumulus–oocyte complexes (COCs) were divided into control (not exposed to BCB), BCB+ (blue cytoplasm) BCB− (colorless groups. We found that yielded a significantly higher...
Numerous post-translational modifications are involved in oocyte maturation and embryo development. Recently, lactylation has emerged as a novel epigenetic modification implicated the regulation of diverse cellular processes. However, it remains unclear whether occurs during development Herein, lysine (Kla) were determined mouse early by immunofluorescence staining. Exogenous lactate was supplemented to explore consequences modulating histone levels on processes transcriptomics. Results...
Mouse preimplantation development is characterized by three major transitions and two lineage segregations. Each transition or segregation entails pronounced changes in the pattern of gene expression. Thus, research into function genes with obvious expression will shed light on molecular basis development. We have described a simplified effective method–electroporation–of introducing plasmid DNA morpholinos mouse embryos verified effectiveness this approach testing procedure endogenous Oct4....
BACKGROUND: Vitrification is assumed to be a promising method cryopreserve human oocytes but still needs optimization. In this study, rabbit (fertilized by ICSI) were vitrified with cryoloops, and the effect of three different cryopreservation protocols on spindle configuration embryo quality was assessed. METHODS: Metaphase II randomly assigned one four groups: (i) control; (ii) E40 [40% ethylene glycol (EG)]; (iii) ED20 [20% EG + 20% dimethylsulphoxide (DMSO)]; (iv) M (20% EG+20% DMSO+...
Coconut palms (Cocos nucifera L.) are globally significant with both economic and cultural value. Despite the increasing demand for coconut products, production is decreasing due to palm senility, pests, diseases. It has been estimated that over half of world’s need be replaced immediately. The industry acknowledged conventional propagation methods unlikely yield sufficient high-quality planting material. Therefore, tissue culture considered a potential solution this problem. By using...
A sensitive and accurate LC-MS/MS method was established for quantifying salvianolic acid B (Sal B), rosmarinic (Ros A) Danshensu (DA) in rat plasma. Salvia miltiorrhiza polyphenolic (SMPA), active water-soluble ingredients isolated purified from Bge included Sal B, Ros DA. The pharmacokinetic analysis of DA after pulmonary administration SMPA solution to performed by LC-MS/MS. Results the studies showed that peak concentration 21.85 ± 6.43 65.39 3.83 ng/mL intravenous administration,...
Two of bioactive natural products were founded in a brown alga, Sargassum fulvellum. After isolation and purification, the molecular structures these two investigated by NMR spectroscopy GC-mass spectroscopy. The compounds identified to be 1-O-palmitoyl-2-O-oleoyl-3-O-(α-D-glucopyranosyl) –glycerol (POGG) 1-O-myristoyl-2-O-oleoyl-3-O-(α-D-glucopyranosyl) – glycerol (MOGG) which obtained from fulvellum for first time. POGG MOGG showed fibrinolytic activity reaction system pro-u-PA plasminogen.
Nasal microsomal P450 form a (NMa), major cytochrome isozyme in rabbit olfactory and respiratory nasal mucosa with high activity toward variety of odorants environmental toxicants, was previously purified to electrophoretic homogeneity from microsomes.In the present study, cDNA library constructed poly(A)+ RNA screened antibodies NMa, five immunopositive clones were isolated characterized.Sequence analysis indicated that encode two highly similar P450s contain 494 amino acid residues, first...
Based on the extended Huygens-Fresnel principle and ITU-R atmospheric turbulence model (the altitude-dependent proposed by International Telecommunication Union-Recommendation in 2001), treatment includes effect of both laser beam as it propagates to target scattered field back receiver. The covariance function variance scattering intensity are derived considering fluctuations log-amplitude phase, numerical results presented. influences wavelength, receiver altitude propagation distance...
Background:Salvia miltiorrhiza polyphenolic acid (SMPA) is effective in the treatment of cardiovascular diseases and currently it administered orally or intravenously. However, SMPA poorly absorbed quickly eliminated vivo. A long-term frequent intravenous administration leads to poor patient compliance. Therefore, urgently demanded find a new alternative route noninjection drug delivery system for SMPA. Methods: Two dry powder inhalation (DPI) formulations spray-dried formulation (P1)...