A5031098125- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Pharmacological Effects of Natural Compounds
- Flavonoids in Medical Research
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Analysis
- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Skin Protection and Aging
- Protein Interaction Studies and Fluorescence Analysis
- Lipid Membrane Structure and Behavior
- Berberine and alkaloids research
- Plant-based Medicinal Research
- Biological Activity of Diterpenoids and Biflavonoids
- Curcumin's Biomedical Applications
- RNA Interference and Gene Delivery
- Alkaloids: synthesis and pharmacology
- Phytochemistry and Biological Activities
- Ginger and Zingiberaceae research
- Apelin-related biomedical research
- Medicinal Plants and Bioactive Compounds
- Ginkgo biloba and Cashew Applications
- Barrier Structure and Function Studies
- Synthesis and Biological Activity
Tianjin University of Traditional Chinese Medicine
2014-2023
Tianjin haihe hospital
2023
Shanghai Institute of Pharmaceutical Industry
2008-2014
Baicalein (BE) is one of the main active flavonoids representing variety pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but it's very low solubility, dissolution rate poor oral absorption limit therapeutic applications. In this work, a nano-cocrystal strategy was successfully applied to improve bioavailability BE. Baicalein-nicotinamide (BE-NCT) nano-cocrystals were prepared by high pressure homogenization evaluated both in vitro...
Abstract Background Poor targeting and penetration of chemotherapy drugs in solid tumors, the development resistance to chemotherapeutic agents are currently hindering therapy breast cancer; meanwhile, cancer metastasis is one leading causes death patients. With nanotechnology, nanomaterials have been widely used tumor therapy. Results A multi-functional nano-platform containing gambogic acid (GA) paclitaxel (PTX) was characterized by a small size, high encapsulation efficiency, slow...
Abstract: Targeted delivery by the folate ligand is an effective way to enhance anti-breast carcinoma effect, due its high affinity for receptor, which overexpressed in many tumor cells. In this study, we firstly synthesized a folic acid (FA)-targeted and polyethylene glycol (PEG)-modified TiO 2 nanocarrier. Then, FA-PEG-TiO nanoparticle (NP) codelivery system loaded with curcumin salvianolic B were prepared emulsion evaporation–solidification at low temperature. The obtained folate-targeted...
Systemic absorption of ocularly administered Brimonidine Tartrate has been reported to give rise several side-effects. Hence, it become crucial develop a delivery system that could increase efficacy and reduce systemic absorption. Therefore, the present work aims gels with different concentrations (0.05%, 0.1%, 0.2% w/v, respectively) using Carbopol 974 P HPMC E4M, compare therapeutic eye drop (0.2%, w/v) by UPLC-MS/MS. The result histological analysis did not show any morphological or...
Tanshinone I (TSI) is one of the bioactive compound obtained from root Salvia miltiorrhiza which a well-known traditional Chinese medicine (TCM) used for treatment various diseases. Although TSI possesses several pharmacological effects, it has poor water solubility, blood-brain barrier (BBB) permeability and brain bioavailability. Therefore, in present study, we developed nanoemulsion (TSI-NE) modified with targeting ligand (Lactoferrin (Lf)) to improve BBB permeability. Pseudo-ternary...
Objective: Inhibition of tumor angiogenesis has become a new targeted therapy. In this study, we established micellar carrier with neovascularization-targeting effect modified by the peptide NGR. Methods: The polymer poly(ethylene glycol)-b-poly(lactide-co-glycolide) (PEG-PLGA) Asn–Gly–Arg (NGR) was prepared and characterized 1 H nuclear magnetic resonance Fourier-transform infrared spectrometry. NGR-PEG-PLGA used to construct curcumin (Cur)-loaded micelles solvent evaporation method....
Ursolic acid (UA), a natural pentacyclic triterpenoid, has been reported to possess variety of pharmacological activities, but the poor oral bioavailability UA owing aqueous solubility and membrane permeability limits further clinical application.The purpose present study was develop nanocrystals microcrystals employing high pressure homogenization (HPH) evaluate their effects on bioavailability.The crystalline morphology prepared by HPH observed scanning electron microscopy state...
The poor ability of recognition and penetration chemotherapeutic agents to tumor cells are still great challenges for targeted breast cancer treatment. Herein, we established a tumor-targeted nanostructured lipid carrier encapsulating gambogic acid (GA) paclitaxel (PTX), which was co-modified with acid-cleavable folic (cFA) human-derived cell penetrating peptide dNP2 (CKIKKVKKKGRKKIKKVKKKGRK). multi-functional nano-platform exhibited an enhanced targeting penetrability tissues, accomplished...
Labrasol, as a non-ionic surfactant, can enhance the permeation and absorption of drugs, is extensively used in topical, transdermal, oral pharmaceutical preparations an emulsifier enhancer. Recent studies our laboratory have indicated that labrasol has strong enhancing effect on different types drugs vitro vivo. This study was performed to further elucidate action mechanism corneal penetration. In this research, fluorescein sodium, marker passive paracellular transport tight junction,...
Due to the effects of gastric acid, glycosidase and intestinal flora in gastrointestinal environment, panax notoginseng saponins (PNS) can easily be resolved metabolized when it is administered orally, limiting its oral bioavailability.The formula PNS nanoemulsion (PNS-N) was optimized using a pseudoternary phase diagram, PNS-N prepared by high pressure homogenization. The type, particle size, polydispersity index (PDI), refractive index, pH content were characterized. In vitro...
Poor in vivo targeting of tumors by chemotherapeutic drugs reduces their anti-cancer efficacy the clinic. The discovery over-expressed components on tumor cell surface and specific ligands provide a basis for cells. However, differences expression levels these receptors limit clinical application anti-tumor preparations modified single ligand. Meanwhile, toxicity leads to poor tolerance therapy. natural active products antagonizing toxic side effects offers an avenue relieving cancer...
Abstract We have evaluated the potential of intranasal administration tramadol. The pharmacokinetic behaviour tramadol in rat plasma and cerebrospinal fluid (CSF) after was determined compared with those intravenous oral administration. Serial CSF samples were collected for 6 h, drug concentrations assayed by an HPLC-fluorescence method. absolute bioavailability values 73.8% 32.4%, respectively, conscious rats. Cmax (maximum concentration) value dose lower (P < 0.05), MRT (mean...
The purpose of this work was to determine and investigate the absorption ginkgo terpenoids (GT) in plasma aqueous humour after oral administration biloba extract (GBE) by UPLC-MS/MS method.The determination GT employed multiple reaction monitoring mode using an electrospray negative ionization. rabbits were orally administered suspension GBE at a dose 500 mg/kg. Serial dialysate samples collected corresponding time then analysed UPLC-MS/MS.In plasma, mean AUC from 0 48 h 14.12, 12.59, 23.75,...