A5065683417- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Inhalation and Respiratory Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nanoparticle-Based Drug Delivery
- Metabolomics and Mass Spectrometry Studies
- Respiratory and Cough-Related Research
- Drug Solubulity and Delivery Systems
- Natural product bioactivities and synthesis
- Hepatitis B Virus Studies
- Berberine and alkaloids research
- Phytochemistry and Biological Activities
- Hepatitis C virus research
- Microencapsulation and Drying Processes
- Chemotherapy-induced organ toxicity mitigation
- Food Quality and Safety Studies
- Advanced Proteomics Techniques and Applications
- Flavonoids in Medical Research
- Natural Compound Pharmacology Studies
- Medicinal Plants and Bioactive Compounds
- Medicinal Plant Research
- Soil Moisture and Remote Sensing
- Natural Antidiabetic Agents Studies
- Advanced Drug Delivery Systems
- Supramolecular Self-Assembly in Materials
Qiqihar Medical University
2024
University of Georgia
2024
Nanjing Medical University
2022-2023
Tianjin haihe hospital
2022
Tianjin University of Traditional Chinese Medicine
2019-2022
Suzhou Traditional Chinese Medicine Hospital
2021-2022
Nanjing University of Chinese Medicine
2021-2022
Kunming University of Science and Technology
2020
Chinese Academy of Sciences
2009-2014
Shanghai Institute of Materia Medica
2008-2009
Idiopathic pulmonary fibrosis (IPF) is a serious and fatal inflammatory disease with an increasing incidence worldwide. The drugs nintedanib pirfenidone, are listed as conditionally recommended in the "Evidence-Based Guidelines for Diagnosis Treatment of Pulmonary Fibrosis". However, these two have many adverse reactions clinical application. Salvianolic acid B (Sal B), water-soluble component Salvia miltiorrhiza, could alleviate bleomycin-induced peroxidative stress damage, prevent or delay...
Background and purpose: Gambogic acid (GA) is a natural compound that exhibited promising multi-target antitumor activity against several types of cancer. However, the clinical application this drug limited due to its poor solubility low tumor cell-specific delivery. In study, monomeric dimeric Cyclo (Arg-Gly-Asp) c(RGD) targeting peptides (c(RGDfK) E-[c(RGDfK)2]) were used modify GA loaded nanostructured lipid carriers (NLC) reduce limitations associated with improve activity. Methods:...
Traditional Chinese medicine (TCM) has been utilized for the treatment of colon cancer. Qizhen decoction (QZD), a potential compound prescription TCM, possesses multiple biological activities. It proven clinically effective in However, molecular mechanism anticolon cancer activity is still not clear. This study aimed to identify chemical composition QZD. Furthermore, collaborative analysis strategy network pharmacology and cell biology was used further explore critical signaling pathway QZD...
Abstract Background Poor targeting and penetration of chemotherapy drugs in solid tumors, the development resistance to chemotherapeutic agents are currently hindering therapy breast cancer; meanwhile, cancer metastasis is one leading causes death patients. With nanotechnology, nanomaterials have been widely used tumor therapy. Results A multi-functional nano-platform containing gambogic acid (GA) paclitaxel (PTX) was characterized by a small size, high encapsulation efficiency, slow...
A sensitive and accurate LC-MS/MS method was established for quantifying salvianolic acid B (Sal B), rosmarinic (Ros A) Danshensu (DA) in rat plasma. Salvia miltiorrhiza polyphenolic (SMPA), active water-soluble ingredients isolated purified from Bge included Sal B, Ros DA. The pharmacokinetic analysis of DA after pulmonary administration SMPA solution to performed by LC-MS/MS. Results the studies showed that peak concentration 21.85 ± 6.43 65.39 3.83 ng/mL intravenous administration,...
Environmental sanitation of maternal contact during pregnancy is extremely important for the development different fetal tissues and organs. In particular, early pregnancy, any adverse exposure may cause abnormal growth or inhibit embryogenic The potential risks phthalate exposure, which affects humans animals, are becoming a serious concern worldwide. However, specific molecular mechanism di-(2-ethylhexyl) (DEHP)-induced cardiotoxicity in mice remains unclear. this study, animal models DEHP...
Background:Salvia miltiorrhiza polyphenolic acid (SMPA) is effective in the treatment of cardiovascular diseases and currently it administered orally or intravenously. However, SMPA poorly absorbed quickly eliminated vivo. A long-term frequent intravenous administration leads to poor patient compliance. Therefore, urgently demanded find a new alternative route noninjection drug delivery system for SMPA. Methods: Two dry powder inhalation (DPI) formulations spray-dried formulation (P1)...
A UHPLC-QQQ-MS/MS method was developed to quantify the significant constituents in Wen-Dan Decoction (WDD), a traditional Chinese medicine. Analysis of 19 compounds conducted on an ACQUITY UPLC® BEH C18 Column (2.1 × 50 mm, 1.7 μm) using elution with gradient acetonitrile and 0.05% (v/v) formic acid water. triple quadrupole mass spectrometer operated negative ionization mode positive by multiple reaction monitoring (MRM), respectively. All calibration curves showed acceptable linearity (r ≥...
Abstract Objective: This study aimed to lay the foundation for research on Panax notoginseng saponins (PNS) in pH-sensitive situ gel and development improvement of related preparations. Methods: We used Carbopol ® 940, a commonly polymer, thickener hydroxypropyl methylcellulose (HPMC E4M) as an ophthalmic matrix prepare PNS. In addition, formula optimization was performed by assessing gelling capability with results vitro release studies. (corneal permeation, rheological, stability) vivo...