A5100448532- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Advanced biosensing and bioanalysis techniques
- Advancements in Transdermal Drug Delivery
- Natural product bioactivities and synthesis
- RNA Interference and Gene Delivery
- Flavonoids in Medical Research
- Corneal Surgery and Treatments
- Plant-based Medicinal Research
- Traditional Chinese Medicine Analysis
- Healthcare and Venom Research
- Supramolecular Chemistry and Complexes
- Ginseng Biological Effects and Applications
- Morinda citrifolia extract uses
- Renal cell carcinoma treatment
- Pharmacological Effects of Natural Compounds
- Bladder and Urothelial Cancer Treatments
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Metabolomics and Mass Spectrometry Studies
- Urinary and Genital Oncology Studies
- Phytochemistry and Biological Activities
- Plasmonic and Surface Plasmon Research
- Sesquiterpenes and Asteraceae Studies
- Computational Drug Discovery Methods
University of Science and Technology of China
2025
Tianjin University of Traditional Chinese Medicine
2013-2024
Tianjin Medical University
2024
Tianjin haihe hospital
2022-2023
Second Hospital of Anhui Medical University
2021
Anhui Medical University
2021
Chinese Academy of Sciences
2016
National Engineering Research Center for Nanotechnology
2015
Abstract A novel three‐dimensional (3D) superstructure based on the growth and origami folding of DNA gold nanoparticles (AuNPs) was developed. The 3D contains a nanoparticle core dozens two‐dimensional belts folded from long single‐stranded DNAs grown in situ by rolling circle amplification (RCA). We designed two mechanisms to achieve loading molecules onto superstructures. In one mechanism, ligands bound target are merged into growing during RCA process (merging mechanism). other...
The purpose of this study was to develop novel liquid crystalline nanoparticles (LCNPs) that display improved pre-ocular residence time and ocular bioavailability can be used as an ophthalmic delivery system for tetrandrine (TET). consisted three primary components, including glyceryl monoolein, poloxamer 407, water, two secondary Gelucire 44/14 amphipathic octadecyl-quaternized carboxymethyl chitosan. amount TET, the ratio 407 monoolein were selected factors optimize dependent variables,...
Abstract A novel three‐dimensional (3D) superstructure based on the growth and origami folding of DNA gold nanoparticles (AuNPs) was developed. The 3D contains a nanoparticle core dozens two‐dimensional belts folded from long single‐stranded DNAs grown in situ by rolling circle amplification (RCA). We designed two mechanisms to achieve loading molecules onto superstructures. In one mechanism, ligands bound target are merged into growing during RCA process (merging mechanism). other...
Objective: Inhibition of tumor angiogenesis has become a new targeted therapy. In this study, we established micellar carrier with neovascularization-targeting effect modified by the peptide NGR. Methods: The polymer poly(ethylene glycol)-b-poly(lactide-co-glycolide) (PEG-PLGA) Asn–Gly–Arg (NGR) was prepared and characterized 1 H nuclear magnetic resonance Fourier-transform infrared spectrometry. NGR-PEG-PLGA used to construct curcumin (Cur)-loaded micelles solvent evaporation method....
As a natural compound, gambogic acid (GA) emerged shining multi-target antitumor activity in variety of tumors. Whereas its poor solubility and non-specific effect to tumor blocked the clinical application this drug. Herein, we reported simple effective strategy construct liposome modified with nuclear targeted peptide CB5005N (VQRKRQKLMPC) via polyethylene glycol (PEG) linker decrease inherent limitations GA promote anti-tumor activity. In study, liposomes were prepared by thin film...
Cancer is a disease with high mortality rate; therefore, research on new treatment strategies essential. There has been increased interest in novel drug delivery systems (DDS) recent years, such as calixarene, one of the most important principal molecules supramolecular chemistry. Calixarene cyclic oligomer phenolic units linked by methylene bridges that belongs to third generation compounds. By modifying hydroxyl end (lower edge) or para-position, wide range calixarene derivatives can be...
Osteoporosis (OP) is a metabolic bone disease with high incidence rate worldwide. Its main features are decreased mass, increased fragility and deterioration of microstructure. It caused by an imbalance between formation resorption. Ginsenoside safe effective traditional Chinese medicine (TCM) usually extracted from ginseng plants, having various therapeutic effects, which the effect against osteoporosis has been extensively studied. We searched total 44 relevant articles using keywords...
Abstract Objectives Asthma is a heterogeneous disease characterized by chronic airway inflammation. Huashanshen dripping pills (HSS) are commonly utilized for relieving asthma, cough, and expelling phlegm. At present, the molecular mechanism against inflammation remains unclear. Methods In this study, network pharmacology, docking technology, dynamic simulation were used to predict therapeutic pathways of HSS asthma. The ovalbumin-induced mouse model was further validate prediction RT-qPCR,...