A5085791891- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- Flavonoids in Medical Research
- Pharmacological Effects of Natural Compounds
- RNA Interference and Gene Delivery
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Ocular Surface and Contact Lens
- Nanoplatforms for cancer theranostics
- Analytical Chemistry and Chromatography
- Computational Drug Discovery Methods
- Skin Protection and Aging
- Antifungal resistance and susceptibility
- Ginkgo biloba and Cashew Applications
- Crystallization and Solubility Studies
- Supramolecular Self-Assembly in Materials
- Protein Interaction Studies and Fluorescence Analysis
- Protease and Inhibitor Mechanisms
- Nutrition, Genetics, and Disease
- Chromatography in Natural Products
- Advanced Technologies in Various Fields
- Connexins and lens biology
- Ginseng Biological Effects and Applications
- Proteoglycans and glycosaminoglycans research
Tianjin University of Traditional Chinese Medicine
2017-2025
Tianjin haihe hospital
2023
Sichuan University
2021
Southwest Forestry University
2020
Shenyang Pharmaceutical University
2014-2015
Justus-Liebig-Universität Gießen
1983
Baicalein (BE) is one of the main active flavonoids representing variety pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but it's very low solubility, dissolution rate poor oral absorption limit therapeutic applications. In this work, a nano-cocrystal strategy was successfully applied to improve bioavailability BE. Baicalein-nicotinamide (BE-NCT) nano-cocrystals were prepared by high pressure homogenization evaluated both in vitro...
Background: Liver cancer, especially hepatocellular carcinoma, a prevalent malignant tumor of the digestive system, poses significant therapeutic challenges. While traditional chemotherapy can inhibit progression, its clinical application is limited by insufficient efficacy. Hydrophobic agents further encounter challenges including low specificity, poor bioavailability, and severe systemic toxicity. This study aimed to develop liver-targeted, glutathione (GSH)-responsive micellar system...
Objective: Inhibition of tumor angiogenesis has become a new targeted therapy. In this study, we established micellar carrier with neovascularization-targeting effect modified by the peptide NGR. Methods: The polymer poly(ethylene glycol)-b-poly(lactide-co-glycolide) (PEG-PLGA) Asn–Gly–Arg (NGR) was prepared and characterized 1 H nuclear magnetic resonance Fourier-transform infrared spectrometry. NGR-PEG-PLGA used to construct curcumin (Cur)-loaded micelles solvent evaporation method....
Systemic absorption of ocularly administered Brimonidine Tartrate has been reported to give rise several side-effects. Hence, it become crucial develop a delivery system that could increase efficacy and reduce systemic absorption. Therefore, the present work aims gels with different concentrations (0.05%, 0.1%, 0.2% w/v, respectively) using Carbopol 974 P HPMC E4M, compare therapeutic eye drop (0.2%, w/v) by UPLC-MS/MS. The result histological analysis did not show any morphological or...
Tanshinone I (TSI) is one of the bioactive compound obtained from root Salvia miltiorrhiza which a well-known traditional Chinese medicine (TCM) used for treatment various diseases. Although TSI possesses several pharmacological effects, it has poor water solubility, blood-brain barrier (BBB) permeability and brain bioavailability. Therefore, in present study, we developed nanoemulsion (TSI-NE) modified with targeting ligand (Lactoferrin (Lf)) to improve BBB permeability. Pseudo-ternary...
As a natural compound, gambogic acid (GA) emerged shining multi-target antitumor activity in variety of tumors. Whereas its poor solubility and non-specific effect to tumor blocked the clinical application this drug. Herein, we reported simple effective strategy construct liposome modified with nuclear targeted peptide CB5005N (VQRKRQKLMPC) via polyethylene glycol (PEG) linker decrease inherent limitations GA promote anti-tumor activity. In study, liposomes were prepared by thin film...
Poor in vivo targeting of tumors by chemotherapeutic drugs reduces their anti-cancer efficacy the clinic. The discovery over-expressed components on tumor cell surface and specific ligands provide a basis for cells. However, differences expression levels these receptors limit clinical application anti-tumor preparations modified single ligand. Meanwhile, toxicity leads to poor tolerance therapy. natural active products antagonizing toxic side effects offers an avenue relieving cancer...
Labrasol, as a non-ionic surfactant, can enhance the permeation and absorption of drugs, is extensively used in topical, transdermal, oral pharmaceutical preparations an emulsifier enhancer. Recent studies our laboratory have indicated that labrasol has strong enhancing effect on different types drugs vitro vivo. This study was performed to further elucidate action mechanism corneal penetration. In this research, fluorescein sodium, marker passive paracellular transport tight junction,...
Nano-targeted delivery systems have been widely used for breast tumor drug delivery. Estrogen receptors are considered to be significant target due their overexpression in a variety of cells. However, targeted ligands impact on the safety and effectiveness active systems, limiting clinical transformation nanoparticles. Phytoestrogens shown good biosafety characteristics some affinity with estrogen receptor. In present study, molecular docking was select tanshinone IIA (Tan IIA) among...
The purpose of this work was to determine and investigate the absorption ginkgo terpenoids (GT) in plasma aqueous humour after oral administration biloba extract (GBE) by UPLC-MS/MS method.The determination GT employed multiple reaction monitoring mode using an electrospray negative ionization. rabbits were orally administered suspension GBE at a dose 500 mg/kg. Serial dialysate samples collected corresponding time then analysed UPLC-MS/MS.In plasma, mean AUC from 0 48 h 14.12, 12.59, 23.75,...
Abstract In einem Inkubationsversuch mit drei Böden (Parabraunerde aus Löß, Auengley Alluvium und Braunerde Basaltverwitterung) wurde die spezifische Bindung von Düngerammonium dessen Wiederfreisetzung untersucht. Der Versuch bestand pro Boden einer Variante, der 120 mg NH 4 – N kg zugegeben worden war, Kontrolle ohne N–Gabe. zehntägigen Abständen wurden Bodenproben gezogen auf ihre Gehalte an nicht austauschbarem (spezifisch gebundenem) + sowie NO 3 Die Untersuchungen bringen zum Ausdruck,...
A UHPLC-QQQ-MS/MS method was developed to quantify the significant constituents in Wen-Dan Decoction (WDD), a traditional Chinese medicine. Analysis of 19 compounds conducted on an ACQUITY UPLC® BEH C18 Column (2.1 × 50 mm, 1.7 μm) using elution with gradient acetonitrile and 0.05% (v/v) formic acid water. triple quadrupole mass spectrometer operated negative ionization mode positive by multiple reaction monitoring (MRM), respectively. All calibration curves showed acceptable linearity (r ≥...
Tongluo-Qutong rubber plaster (TQRP) is a well-known traditional Chinese medicine prescription for the treatment of osteoarthritis and cervical spondylosis. Due to lack in vivo permeation data, active ingredients TQRP have not been fully elucidated, presenting huge obstacle quality evaluation, pharmacokinetic studies, safety assessment clinical application. In this study, selective reproducible ultraperformance liquid chromatography tandem mass spectrometry method was developed validated...