A5024170132- Renal Diseases and Glomerulopathies
- GaN-based semiconductor devices and materials
- Ga2O3 and related materials
- Advancements in Transdermal Drug Delivery
- Chronic Kidney Disease and Diabetes
- Traditional Chinese Medicine Analysis
- ZnO doping and properties
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Metal and Thin Film Mechanics
- Pharmacological Effects of Natural Compounds
- Systemic Sclerosis and Related Diseases
- Nanoparticle-Based Drug Delivery
- Acoustic Wave Resonator Technologies
- Natural Antidiabetic Agents Studies
- Supercapacitor Materials and Fabrication
- Renal and Vascular Pathologies
- Chromatography in Natural Products
- Skin Protection and Aging
- Ocular Surface and Contact Lens
- Gas Sensing Nanomaterials and Sensors
- Glaucoma and retinal disorders
- Advanced Glycation End Products research
- Connexins and lens biology
- Advanced materials and composites
Shenyang Ligong University
2010-2025
Tianjin University of Traditional Chinese Medicine
2016-2025
Shenzhen Second People's Hospital
2019-2024
Shenzhen University
2020-2024
Tianjin haihe hospital
2023
China Pharmaceutical University
2012-2020
Shenyang University
2017
Diabetic retinopathy is a complex disease that potentially involves increased production of advanced glycosylation end products (AGEs) and elevated aldose reductase (AR) activity, which are related with oxidative stress inflammation. The aim this study was to investigate the effects hesperidin on retinal plasma abnormalities in streptozotocin-induced diabetic rats. Hesperidin (100, 200 mg/kg daily) given rats for 12 weeks. blood-retina breakdown (BRB) determined after 2 weeks treatment...
Baicalein (BE) is one of the main active flavonoids representing variety pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but it's very low solubility, dissolution rate poor oral absorption limit therapeutic applications. In this work, a nano-cocrystal strategy was successfully applied to improve bioavailability BE. Baicalein-nicotinamide (BE-NCT) nano-cocrystals were prepared by high pressure homogenization evaluated both in vitro...
The available evidence on the connection between excessive alcohol consumption and diabetes is controversial. Therefore, primary objective of this investigation was to examine incident in a Japanese population through utilization propensity score matching (PSM) analysis. Our retrospective cohort study encompassed sample 15,464 individuals who were initially free years 2004 2015. utilized comprehensive medical records underwent physical examination. Employing one:one PSM analysis, current...
Abstract: Targeted delivery by the folate ligand is an effective way to enhance anti-breast carcinoma effect, due its high affinity for receptor, which overexpressed in many tumor cells. In this study, we firstly synthesized a folic acid (FA)-targeted and polyethylene glycol (PEG)-modified TiO 2 nanocarrier. Then, FA-PEG-TiO nanoparticle (NP) codelivery system loaded with curcumin salvianolic B were prepared emulsion evaporation–solidification at low temperature. The obtained folate-targeted...
Systemic absorption of ocularly administered Brimonidine Tartrate has been reported to give rise several side-effects. Hence, it become crucial develop a delivery system that could increase efficacy and reduce systemic absorption. Therefore, the present work aims gels with different concentrations (0.05%, 0.1%, 0.2% w/v, respectively) using Carbopol 974 P HPMC E4M, compare therapeutic eye drop (0.2%, w/v) by UPLC-MS/MS. The result histological analysis did not show any morphological or...
Tanshinone I (TSI) is one of the bioactive compound obtained from root Salvia miltiorrhiza which a well-known traditional Chinese medicine (TCM) used for treatment various diseases. Although TSI possesses several pharmacological effects, it has poor water solubility, blood-brain barrier (BBB) permeability and brain bioavailability. Therefore, in present study, we developed nanoemulsion (TSI-NE) modified with targeting ligand (Lactoferrin (Lf)) to improve BBB permeability. Pseudo-ternary...
Renal anaemia is a common complication of chronic kidney disease (CKD) and the severity increases with deterioration renal function [1]. Anaemia known to be associated increased morbidity mortality cardiovascular [2]. Roxadustat new oral prolyl hydroxylase domain (PHD) protein inhibitor that extensively used for treatment in CKD patients [3–7]. The most side effects reported clinical trials are high blood pressure, myocardial infarction, heart failure, infections thrombosis. So far, only two...
Poor in vivo targeting of tumors by chemotherapeutic drugs reduces their anti-cancer efficacy the clinic. The discovery over-expressed components on tumor cell surface and specific ligands provide a basis for cells. However, differences expression levels these receptors limit clinical application anti-tumor preparations modified single ligand. Meanwhile, toxicity leads to poor tolerance therapy. natural active products antagonizing toxic side effects offers an avenue relieving cancer...
Labrasol, as a non-ionic surfactant, can enhance the permeation and absorption of drugs, is extensively used in topical, transdermal, oral pharmaceutical preparations an emulsifier enhancer. Recent studies our laboratory have indicated that labrasol has strong enhancing effect on different types drugs vitro vivo. This study was performed to further elucidate action mechanism corneal penetration. In this research, fluorescein sodium, marker passive paracellular transport tight junction,...