A5018580304- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Diamond and Carbon-based Materials Research
- Advancements in Battery Materials
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Advanced Chemical Physics Studies
- Advanced Photocatalysis Techniques
- Covalent Organic Framework Applications
- Laser-Matter Interactions and Applications
- Photoacoustic and Ultrasonic Imaging
- RNA Interference and Gene Delivery
- Mechanical and Optical Resonators
- Liver Disease and Transplantation
- Photodynamic Therapy Research Studies
- Supercapacitor Materials and Fabrication
- Advanced Battery Technologies Research
- Spectroscopy and Quantum Chemical Studies
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Advanced MRI Techniques and Applications
- Boron Compounds in Chemistry
- Atomic and Molecular Physics
- Boron and Carbon Nanomaterials Research
- Angiogenesis and VEGF in Cancer
Jilin Jianzhu University
2014-2025
First Hospital of Qinhuangdao
2022-2025
Peking University People's Hospital
2016-2025
Peking University
2016-2025
Sun Yat-sen University
2024-2025
Zhejiang University
2025
Xi'an Honghui Hospital
2024
Soochow University
2016-2024
Shandong University
2018-2024
Chinese PLA General Hospital
2020-2024
Real-time temperature monitoring inside living organisms provides a direct measure of their biological activities, such as homeostatic thermoregulation and energy metabolism. However, it is challenging to reduce the size bio-compatible thermometers down submicrometers despite potential applications for thermal imaging subtissue structures with single-cell resolution. Light-emitting nanothermometers that remotely sense via optical signals exhibit considerable in \textit{in-vivo}...
Light harvesting, separation of charge carriers, and surface reactions are three fundamental steps that essential for an efficient photocatalyst. Here we show these in the TiO2 can be boosted simultaneously by disorder engineering. A solid-state reduction reaction between sodium forms a core-shell c-TiO2@a-TiO2-x(OH)y heterostructure, comprised HO-Ti-[O]-Ti frustrated Lewis pairs (SFLPs) embedded amorphous shell surrounding crystalline core, which enables new genre chemical reactivity....
Abstract Background & Aims Following the classification of metabolic dysfunction‐associated fatty liver disease (MAFLD), non‐alcoholic (NAFLD) has recently been redefined again as steatotic (MASLD). However, distinctions in characteristics and mortality outcomes between NAFLD, MAFLD MASLD remain unclear. Methods We analysed data from 7519 participants third National Health Nutrition Examination Surveys United States (US) their linked until 2019. Survey weight‐adjusted multivariable Cox...
Making even tiny diamonds valuable: Nanodiamonds (NDs) were covalently functionalized with hyperbranched polyglycerol (PG) by ring-opening polymerization to improve their suitability for biomedical applications (see scheme). The PG-grafted NDs highly soluble not only in pure water (>20 mg mL−1), but also a buffer (>16 and separated according size size-exclusion chromatography.
Upon contact with biofluids, proteins are quickly adsorbed onto the nanoparticle (NP) surface to form a protein corona, which initiates opsonization and facilitates rapid clearance of NP by macrophage uptake. Although polyethylene glycol (PEG) functionalization has been standard approach evade uptake reducing adsorption, it cannot fully eliminate nonspecific Herein, polyglycerol (PG) grafting is demonstrated as better alternative PEG. NPs various size material were grafted PG PEG at 30, 20,...
In the field of nanomedicine, nanoparticles with various functions are required for in vivo applications such as biomedical imaging and drug delivery. Therefore, chemical functionalization has been extensively investigated. Herein, nanodiamond (ND) coated polyglycerol (PG) its derivatives is reported to impart good solubility a physiological environment, stealth nature avoid nonspecific uptake, targeting property be taken up by specific cell, an acid‐responsive release kill cancer cells. ND...
A highly fluorescent conjugated microporous polymer with amidoxime is reported for concurrent adsorption and detection of uranium under acidic conditions.
Abstract Boron neutron capture therapy (BNCT) has emerged as a treatment modality with high precision and efficacy of intractable tumors. At the core effective tumor BNCT are 10 B carriers facile preparation well advantageous pharmacokinetic therapeutic profiles. Herein, design sub‐10 nm B‐enriched hexagonal boron nitride nanoparticles grafted poly(glycerol) (h‐ BN‐PG), their application to cancer by reported. By virtue small particle size outstanding stealth property, h‐ BN‐PG accumulate...
Transition metal phosphides (TMPs) have emerged as promising anode materials for lithium-ion batteries (LIBs). However, their poor intrinsic conductivity and significant volume changes result in slow redox kinetics structural collapse during cycling, which hinder practical application. Here, a hierarchical hybrid is synthesized by evenly dispersing Ni2P particles with N-doped carbon encapsulation on Co(OH)2 nanosheets (Co(OH)2/Ni2P@N–C). This distinctive structure enhances electron/ion...
Abstract For biomedical application of nanoparticles, the surface chemical functionality is very important to impart additional functions, such as solubility and stability in a physiological environment, targeting specificity an imaging probe drug carrier. Although polyethylene glycol (PEG) has been used extensively, here, it proposed that hyperbranched polyglycerol (PG) good or even better alternative PEG. Superparamagnetic iron oxide nanoparticles (SPIONs) prepared using polyol method are...
Triple negative breast cancer (TNBC) has the poorest prognosis of all subtypes and is one most fatal diseases for women. Combining cytotoxic chemotherapy with immunotherapy shown great promise TNBC treatment. However, often leads to development chemoresistance severe systemic toxicity compromising immune functions that are crucial anti-TNBC therapy. Tumor-induced immunosuppression also poses a hindrance efficacious immunotherapy. Nanomedicine holds overcome these...
To mechanistically prove the concept of monocyte-mediated nano drug delivery in glioblastoma (GBM).nano-doxorubicin-loaded monocytes (Nano-DOX-MC) were viable, able to cross an artificial endothelial barrier and capable infiltrating GBM spheroids releasing therein. cells stimulated unloading Nano-DOX-MC took up unloaded released damage-associated molecular patterns. In mice with orthotopic xenografts, resulted much improved tumor efficacy patterns emission. Mechanistically, Nano-DOX was...
Tumor-associated macrophages (TAMs) are the most abundant stromal cells in tumor microenvironment. Turning TAMs against their host is an intriguing therapeutic strategy particularly attractive for patients with immunologically "cold" tumors. This concept was mechanistically demonstrated on vitro human and murine lung cancer corresponding TAM models through combinatorial use of nanodiamond-doxorubicin conjugates (Nano-DOX) a PD-L1 blocking agent BMS-1. Nano-DOX previously proved to be able...
The present work aims to prove the concept of tumor-targeted drug delivery mediated by platelets. Doxorubicin (DOX) attached nanodiamonds (ND-DOX) was investigated as model payload In vitro experiments first showed that ND-DOX could be loaded in mouse platelets a dose-dependent manner with markedly higher efficiency and capacity than free DOX. ND-DOX-loaded (Plt@ND-DOX) maintained viability stably held for at least 4 hr. Next, Lewis lung cancer cells were found activate Plt@ND-DOX thereby...
The ratio of nonhigh-density lipoprotein cholesterol (non-HDL-C) to high-density (HDL-C) has been shown associated with various metabolic diseases and atherosclerosis in primary prevention. However, there is limited evidence on the relationship between non-HDL-C/HDL-C progression nonculprit coronary lesion (NCCL) after percutaneous intervention (PCI).