A5059487140- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Malaria Research and Control
- Bacteriophages and microbial interactions
- Viral Infections and Outbreaks Research
- CRISPR and Genetic Engineering
- Viral Infections and Vectors
- Infection Control and Ventilation
- Synthesis and biological activity
- Insect symbiosis and bacterial influences
- Cancer Research and Treatments
- Influenza Virus Research Studies
- Ferroptosis and cancer prognosis
- Bacillus and Francisella bacterial research
- COVID-19 and healthcare impacts
- Ubiquitin and proteasome pathways
- Iron Metabolism and Disorders
- Plant-based Medicinal Research
- Research on Leishmaniasis Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Hepatitis B Virus Studies
- Autophagy in Disease and Therapy
- Poxvirus research and outbreaks
- Viral gastroenteritis research and epidemiology
- Drug-Induced Hepatotoxicity and Protection
Academy of Military Medical Sciences
2004-2025
Institute of Microbiology
2004-2024
Institute of Microbiology
2017
Melanoma, the most aggressive skin cancer, is mainly treated with BRAF inhibitors or immunotheareapy. However, patients who initially responded to immunotheareapy become resistant following relapse. Ferroptosis a form of regulated cell death characterized by its dependence on iron ions and accumulation lipid reactive oxygen species (ROS). Recent studies have demonstrated that ferroptosis good method for tumor treatment, homeostasis closely associated ferroptosis. Iron regulatory protein...
Background: Influenza, a seasonal infectious disease, has consistently posed formidable challenge to global health in recent years. Favipiravir, an RNA-dependent RNA polymerase inhibitor, serves as anti-influenza medication, currently administered solely oral form for clinical use. However, achieving effective therapeutic outcome often necessitates high doses, which can be accompanied by adverse effects and suboptimal patient adherence. Objective: To enhance favipiravir delivery efficiency...
Abstract Autophagy is a self‐proteolytic process that degrades intracellular material to maintain cellular homeostasis. Transcription factor EB (TFEB) the master activator regulates transcription of genes involved in autophagy and lysosomal biogenesis. However, cotranscriptional factors TFEB are rarely identified. Here, we found Yin Yang 1 (YY1) regulated lysosome biogenesis melanoma cells. YY1 cooperates with regulate through controlling related genes. Moreover, suppression enhanced...
Abstract At room temperature, SARS-CoV-2 was stable on environmental surfaces and remained viable up to 7 days smooth surfaces. This virus could survive for several hours in feces 3-4 urine.
The Lassa virus (LASV) causes fever, a highly infectious and lethal agent of acute viral hemorrhagic fever. At present, there are still no effective treatments available, creating an urgent need to develop novel therapeutics. Some benzimidazole compounds targeting the arenavirus envelope glycoprotein complex (GPC) promising inhibitors LASV. In this study, we synthesized two series LASV based on structure. Lentiviral pseudotypes bearing GPC were established identify entry inhibitors. Surface...
Since 2015, 69 countries and territories have reported evidence of vector-borne Zika virus (ZIKV) transmission. Currently, there are no effective licensed vaccines or drugs available for the treatment prevention ZIKV infection. We tested a series compounds their ability to inhibit replication in cell culture. The T-705 (favipiravir) T-1105 were found antiviral activity, suggesting that these promising candidates further development as specific against ZIKV.
Artemisinin (ART) is an efficacious and safe anti-malarial drugs but has low oral bioavailability auto-induction profiles during multiple dosing. The pharmacokinetic disadvantages have been found to partially depend on the induction of cytochrome P-450 enzymes by ART resulted in therapeutic failure due insufficient drug levels. present study, therefore, investigated impacts chrysosplenetin (CHR), a polymethoxylated flavonoid from Artemisia annua, pharmacokinetics efficacy against Plasmodium...
The main protease (3-chymotrypsin-like protease, 3CLpro) of SARS-CoV-2 has become a focus anti-coronavirus research. Despite efforts, drug development targeting 3CLpro been hampered by limitations in the currently available activity assays. Additionally, emergence mutations circulating variants raised concerns about potential resistance. Both emphasize need for more reliable, sensitive, and facile assay. Here, we report an orthogonal dual reporter-based gain-of-signal assay measuring living...
Naphthoquine is a promising candidate for antimalarial combination therapy. Its with artemisinin has demonstrated excellent efficacy in clinical trials conducted across various malaria-endemic areas. A co-formulated of naphthoquine and azithromycin also shown high malaria prophylaxis Southeast Asia. Developing new therapies using will provide additional arsenal responses to the growing threat resistance. Furthermore, due its long half-life, possible interaction other drugs needs attention....
We performed Ebola virus disease diagnosis and viral load estimation for cases in Sierra Leone during the late stage of 2014–2015 outbreak (January–March 2015) analyzed antibody cytokine levels genome sequences. was confirmed 86 1001 (9.7%) patients, with an overall case fatality rate 46.8%. Fatal exhibited significantly higher loads, cytokines, chemokines at stages infection versus early compared survivors. The viruses converged a new clade within sublineage 3.2.4, which had lower rate.
COVID-19 has spread around the world and caused serious public health social problems. Although several vaccines have been authorized for emergency use, new effective antiviral drugs are still needed. Some repurposed including Chloroquine, Hydroxychloroquine Remdesivir were immediately used to treat after pandemic. However, therapeutic effects of these not fully demonstrated in clinical studies. In this paper, we found an antimalarial drug, Naphthoquine, showed good broad-spectrum...
Combination therapy using drugs with different mechanisms of action is the current state art in antimalarial treatment. However, except for artemisinin-based combination therapies, only a few other combinations are now available. Increasing concern regarding emergence and spread artemisinin resistance Plasmodium falciparum has led to need development new antimalarials. Moreover, efficacy available chemoprophylaxis compromised by drug noncompliance due intolerable adverse effects or...
Papain-like protease (PLpro) is an attractive anti-coronavirus target. The development of PLpro inhibitors, however, hampered by the limitations existing assay and scarcity validated active compounds. We developed a novel in-cell based on BRET used it to evaluate discover SARS-CoV-2 inhibitors. demonstrated remarkable sensitivity for detecting reduction intracellular activity while presenting high reliability performance inhibitor evaluation high-throughput screening. Using this assay, three...
Infection with Yersinia pestis (Y. pestis) may cause pneumonic plague, which is inevitably fatal without treatment. Gentamicin (GM), an aminoglycoside antibiotic, a drug commonly used in the treatment of plague. However, it requires repeated intramuscular or intravenous administration. Pulmonary delivery noninvasive, advantages local targeting and reduced risk systemic toxicity. In this study, GM powders were prepared using spray-drying technology. The displayed good physical chemical...
Aim: Naphthoquine (NQ) was discovered by our institute as an antimalarial candidate in 1980s, and currently employed artemisinin-based combination therapy partner drug. Resistance to NQ found mouse model laboratory, might emerge future widely used. Methodology: We herein report the design synthesis of derivatives replacing t-butyl moiety with linear/cyclic structured pendants. All target compounds 6a-l intermediates 5a-h were tested for their vivo activity against Plasmodium berghei K173...