A5064633669- CAR-T cell therapy research
- Chemotherapy-induced cardiotoxicity and mitigation
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Cell death mechanisms and regulation
- Cancer Treatment and Pharmacology
- Hepatitis C virus research
- Hepatitis B Virus Studies
Xiamen University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013
Fibrosarcoma, a malignant mesenchymal tumor, is characterized by aggressive invasiveness and high recurrence rate, leading to poor prognosis. Anthracycline drugs, such as doxorubicin (DOX), represent the frontline chemotherapy for fibrosarcoma, but often exhibit suboptimal efficacy. Recently, exploiting stimulator of interferon genes (STING)-mediated innate immunity has emerged hopeful strategy cancer treatment. Integrating with immunomodulators in chemo-immunotherapy shown potential...
In previous studies, it has been shown that recombinant human neuregulin-1(rhNRG-1) is capable of improving the survival rate in animal models doxorubicin (DOX)-induced cardiomyopathy; however, underlying mechanism this phenomenon remains unknown. study, role rhNRG-1 attenuating doxorubicin-induce apoptosis confirmed. Neonatal rat ventricular myocytes (NRVMs) were subjected to various treatments, order both induce and determine effects on process. Activation was determined by observing...
HBV infection is a global health burden. Covalently closed circular DNA (cccDNA) transcriptional regulation major cause of poor cure rates chronic hepatitis B (CHB) infection. Herein, we evaluated whether targeting host factors to achieve functional silencing cccDNA may represent novel strategy for the treatment infection.To evaluate effects Jumonji C domain-containing (JMJD2) protein subfamily JMJD2A-2D proteins on replication, used lentivirus-based RNA interference suppress expression...