A5067800102- Metabolomics and Mass Spectrometry Studies
- Curcumin's Biomedical Applications
- Traditional Chinese Medicine Analysis
- Mass Spectrometry Techniques and Applications
- Drug Transport and Resistance Mechanisms
- Advanced Proteomics Techniques and Applications
- Bioactive Compounds and Antitumor Agents
- Lipid Membrane Structure and Behavior
- Coconut Research and Applications
- Phytochemicals and Antioxidant Activities
- Computational Drug Discovery Methods
- Natural product bioactivities and synthesis
- Cancer therapeutics and mechanisms
- Analytical Chemistry and Chromatography
- Sphingolipid Metabolism and Signaling
- Bioactive natural compounds
- Chemical Reactions and Isotopes
- Morinda citrifolia extract uses
- Metal complexes synthesis and properties
- Medicinal Plant Pharmacodynamics Research
- Natural Antidiabetic Agents Studies
- Cholesterol and Lipid Metabolism
- Synthesis and Biological Evaluation
- Nanoparticle-Based Drug Delivery
- Tea Polyphenols and Effects
Huazhong University of Science and Technology
2016-2023
Union Hospital
2021-2023
Union Hospital
2021
Kuding tea are used as a traditional material and widely consumed in China. In this study, total saponins (TS) from water extract of was prepared by D101 macroporous resins analyzed UPLC-QTOF-MS/MS. Then the hypolipidemic effect TS investigated high-fat diet-induced hyperlipidemic mice. For comprehensive identification or characterization extract, 3 major Kudinoside A, F, D were isolated standards to investigate MS/MS fragmentation pattern. As result, 52 identified characterized tea....
This study is the first to reveal preventive mechanism of dietary turmeric on hyperlipidemia from proteomics in a mouse model.
Cisplatin is widely used for the treatment of various solid tumors. It mainly administered by intravenous injection, and a substantial amount drug will bind to plasma proteins, feature that closely related its pharmacokinetics, activity, toxicity, side effects. However, due unique properties platinum complexes complexity blood proteome, existing methods cannot systematically identify binding proteome cisplatin in blood. In this study, high-abundance protein separation an ion mobility mass...