A5033661011- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Endometriosis Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Uterine Myomas and Treatments
- Management of metastatic bone disease
- Advanced Radiotherapy Techniques
- Sarcoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Autopsy Techniques and Outcomes
- Gastric Cancer Management and Outcomes
- Medical Imaging and Analysis
- Forensic Entomology and Diptera Studies
- Lung Cancer Diagnosis and Treatment
- AI in cancer detection
- Estrogen and related hormone effects
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Peking Union Medical College Hospital
2020-2024
Central South University
2022-2023
Xiangya Hospital Central South University
2022-2023
National Clinical Research
2022
Shandong First Medical University
2022
Abstract Purpose We analyzed clinical features and the representative HE-stained pathologic images to predict 5-year overall survival via deep-learning approach in cervical cancer patients order assist oncologists designing optimal treatment strategies. Methods The research retrospectively collected 238 non-surgical treated with radiochemotherapy from 2014 2017. These were randomly divided into training set ( n = 165) test 73). Then, we extract deep after segmenting image patches of size 224...
To validate the 2018 revised FIGO cervical cancer staging system for stage III patients with a cohort from China.Patients (FIGO 2018) treated definitive radiotherapy at our institute were reviewed. Each patient was evaluated both 2014 and systems. Disease-free survival (DFS) calculated Kaplan-Meier method. Receiver operative characteristic (ROC) curves predictive accuracy of DFS in according to different systems created.Between January 2008 December 2014, total 586 IIIC (2018) institute. The...
Abstract Objective We evaluated whether radiomic features extracted from planning computed tomography (CT) scans predict clinical end points in patients with locally advanced cervical cancer (LACC) undergoing intensity‐modulated radiation therapy and brachytherapy. Design A retrospective cohort study. Setting Xiangya Hospital of Central South University, Changsha, Hunan, China. Population Two hundred fifty‐seven LACC who were treated radiotherapy 2014 to 2017. Methods Patients allocated into...
Background: Nodal failure is a major pattern for patients with FIGO IIIC cervical cancer, which further associated worse survival. This study was designed to investigate risk factors nodal in cancer patients. Methods: The characteristics of positive lymph nodes (LNs) and relevant clinical 162 were collected. chi-square test logistic regression model used identify failure. Results: In total, 368 LNs identified, including 307 pelvic 61 para-aortic LNs. rates all LNs, 9.2%, 7.8%, 16.4%,...
This work aims to analyze the 100 most cited papers in radiotherapy or chemoradiotherapy for cervical cancer.The between 1990 and 2020 were identified with Thompson Reuters Web of Science citation indexing on August 24, 2020. The publication years, source titles, countries/regions, total citations, average citations per year extracted from Science. research type domain classified by authors.These a 28,714 times, median number was 169.5 (ranging 116 1,700 times). paper "Concurrent...
Abstract Background: Endometrial cancer (EC) represents a prevalent malignancy amongst women on global scale, with adjuvant therapy strategy remaining inconsistent and controversial. Identifying subtypes integrated molecular characteristics improves the understanding of biology consequently helps physicians make personalized therapeutic decision-making. Presented herewith is study protocol detailing phase III trial poised to integrate profiling traditional parameters for stratification...
Abstract Purpose To validate the nodal center coverage (NCC) of three mainstream delineation methods para‐aortic clinical target volume (CTV) and propose a modified method CTV in prophylactic extended‐field irradiation (EFI) cervical cancer. Methods A total 106 patients with lymph nodes (PALNs) identified on PET/CT were included at Peking Union Medical College Hospital between 2011 2020. PALNs classified as left lateral (LLPA), aorto‐caval (AC), right para‐caval (RPC). Distances from to...
Abstract Objective The study aimed to evaluate site‐specific recurrent patterns via competing risks analysis and hazard function provide evidence for adjuvant treatment follow‐up early staged endometrial cancer (EC). Methods A total of 858 patients with International Federation Gynecology Obstetrics stage I–II EC who received radiotherapy at our institution (2000–2017) were included. modality comprised external beam (EBRT) or without vaginal brachytherapy (VBT) VBT alone. Competing rate...
Purpose: To evaluate the recurrent patterns and effect of clinicopathological factors on survival after recurrence (R-OS) in early stage endometrial cancer (EC). Methods: Patients with FIGO I-II EC, who underwent post-surgery radiotherapy (RT) at our institution between 2000 2017, were enrolled. First patterns, overall (OS), R-OS evaluated. Univariate multivariate analyses (MVA) used to associated R-OS. Results: 756 patients analyzed including 510 received vaginal brachytherapy (VBT) 246...
Abstract Objective To investigate the clinical outcomes and recurrence patterns of high‐intermediate‐risk (HIR)‐ high‐risk (HR) early‐stage endometrial cancer (EC) treated with postoperative intracavitary brachytherapy alone. Methods We included 152 patients International Federation Gynecology Obstetrics (FIGO) stage I‐II HIR HR factors who received vaginal alone after surgery in our center between April 2008 December 2017. The irradiation area was top upper halves vagina. reference point...
Objectives: We evaluated radiotherapy planning CT-based radiomics for predicting clinical endpoints [tumor complete response (CR), 5-year overall survival (OS), hypohemoglobin, and leucopenia] after intensity-modulated radiation therapy (IMRT) in locally advanced cervical cancer (LACC). Methods: This study retrospectively collected 257 LACC patients treated with IMRT from 2014 to 2017. Patients were allocated into the training/validation sets (3:1 ratio) using proportional random sampling,...
This study aimed to compare the outcomes of RT modalities among patients who met different HIR criteria based on multicentric real-world data over 15 years. The enrolled patients, were diagnosed with FIGO I-II EC from 13 medical institutes and treated hysterectomy RT, reclassified into groups according GOG-249, PORTEC-2, ESTRO-ESMO-ESGO, respectively. trends in modes utilization reviewed using Man-Kendall test. rate VBT alone increased zero 2005 50% 2015, which showed a significant upward...