Abstract Accumulating evidence suggests long noncoding RNAs (lncRNAs) play an important role in cancer progression. However, the function of lncRNA SNHG7 colorectal (CRC) remains unclear. In this study, expression was significantly upregulated CRC tissues, especially aggressive cases. accordance, high level observed cell lines compared to normal colon cells. Furthermore, overexpression promoted proliferation, migration, and invasion lines, while depletion inhibited viability vitro....

Colorectal cancer (CRC) arises in a multistep molecular network process, which is from either discrete genetic perturbation or epigenetic dysregulation. The long non-coding RNAs (lncRNAs), emerging as key molecules human malignancy, has become one of the hot topics RNA biology. Aberrant O-glycosylation well-described hallmark many cancers. GALNT7 acts glycosyltransferase protein O-glycosylation, involving occurrence and development CRC. microarrays were used to survey lncRNA mRNA expression...

Osteoarthritis (OA) is a chronic joint disease and hard to cure at present. Accumulating evidence suggests long noncoding RNA-HOTAIR (lncRNA-HOTAIR) plays important role in OA progression. However, the underlying molecular mechanism of HOTAIR progression has not been well elucidated. In present study, we identified that level was upregulated cartilage tissues. High expression correlated with modified Mankin scale, extracellular matrix (ECM) degradation chondrocytes apoptosis. The miR-17-5p...

The unprecedented oxidative dearomatization-induced [5+2] cycloaddition/pinacol-type 1,2-acyl migration cascade efficiently generates a quaternary carbon center and assembles the highly oxygenated bicyclo[3.2.1]octane framework of ent-kaurene diterpenoids. By incorporation subsequent retro-aldol/aldol process singlet oxygen ene reaction, this concise convergent approach has enabled first asymmetric total syntheses pharicin A, pharicinin B, 7-O-acetylpseurata C, pseurata C.

A hydrogen atom transfer (HAT)-initiated Dowd-Beckwith rearrangement reaction was developed, which enables the efficient assembly of diversely functionalized polyquinane frameworks. By incorporation an iridium-catalyzed regio- and enantioselective hydrogenation a diastereocontrolled ODI-[5+2] cycloaddition/pinacol cascade reaction, asymmetric total syntheses eight tetraquinane natural products, including (-)-crinipellins A-F (-)-dihydrocrinipellins B, have been achieved in concise divergent manner.

The asymmetric and divergent total syntheses of two phragmalin (moluccensins G H) khayanolide-type (krishnolide F khayseneganin F) limonoids were disclosed, which employed a torquoselective interrupted Nazarov cyclization as the key step. Taken together with Liebeskind-Srogl coupling, benzoin condensation, bidirectional acyloin rearrangements, our strategy would simplify synthetic design both facilitate their modular syntheses. Moreover, described approach also provides additional insights...

Sialylation is associated with cancer progression. Long noncoding RNAs (lncRNAs) have important roles in diverse diseases including cancer. The lncRNA ST3Gal6 antisense 1 (ST3Gal6‐AS1) derives from the promoter region of sialyltransferase ST3Gal6. However, mechanisms by which ST3Gal6‐AS1 modulates colorectal (CRC) development through sialylation remain largely unknown. Here, we found that and levels were lower tumor tissues than adjacent normal CRC patients. correlation between was further...

ConspectusTetracyclic diterpenoids (C20) mainly refer to the plant terpenoids bearing biogenetically related carbon skeletons derived from copalyl diphosphates (ent-CPP and syn-CPP). This large family contains over 1600 known members that can be categorized into 11 major structural types. Among them, more than three-quarters share a bridged bicyclo[3.2.1]octane subunit, which is also an important branching point in biosynthesis en route other types of bicyclic scaffolds, such as...

Abstract Objectives Accumulating evidence demonstrated that the long noncoding RNA (lnc ) H OTAIR (Hox transcript antisense intergenic plays key role in renal cell carcinoma ( RCC malignancy, while micro ‐124 (miR‐124) is a tumour suppressor . The aim of this work was to assess biological function HOTAIR and explore underlying mechanism involved /miR‐124/alpha‐2, 8‐sialyltransferase 4 ST 8 SIA 4) axis‐regulated progression Materials methods Real‐time PCR analyses western blots were performed...

Tumor metastasis is a major cause of cancer‐related death in renal cell carcinoma (RCC). MicroRNAs (miRNAs) have been widely known to modulate proliferation invasion, metastasis, and apoptosis cancer cells. In this study, we aimed investigate the function novel target miR‐193a‐3p miR‐224 RCC. The levels were significantly increased RCC tissues lines. Alpha‐2,3‐Sialyltransferase IV (ST3GalIV) was highly expressed adjacent nontumor human normal proximal tubular line HK‐2 compared ST3GalIV...

Liver metastasis is the leading cause of death in colorectal carcinoma (CRC). However, little known about mechanisms transferring effector messages between primary tumor and site metastasis. Exosomes provide a novel transfer message method, exosomal circular RNAs (circRNAs) play critical regulatory roles cancer biology. In this study, results showed that expression circPABPC1 was aberrantly upregulated CRC tissues exosomes. Exosomal considered an oncogene by functional experimental analysis...

A divergent [5+2] cascade approach to bicyclo[3.2.1]octanes was described, enabling the rapid synthesis of diversely functionalized<italic>ent</italic>-kaurene and cedrene-type skeletons.

Abstract The first enantioselective total synthesis of (+)‐steenkrotin A has been achieved in 18 steps and 4.2 % overall yield. key features the strategy entail a Rh‐catalyzed O−H bond insertion followed by an intramolecular carbonyl‐ene reaction, two sequential SmI 2 ‐mediated Ueno–Stork ketyl–olefin cyclizations, cascade aldol condensation/vinylogous retro‐aldol/aldol process with inversion relative configuration at C7 position. absolute was determined based on stepwise construction...

An asymmetric and efficient approach for the total syntheses of (+)-stemarin proposed structures stemara-13(14)-en-18-ol stemara-13(14)-en-17-acetoxy-18-ol are described. The key features strategy include a Lewis acid-induced cationic polyene cyclization an ODI-[5+2] cycloaddition/pinacol-type 1,2-acyl migration cascade.

The strategy of employing directing groups in C-H activation appears to be a big success today's chemical synthesis due its high efficiency and environmental friendly process. As various methodologies have been developed by using copper, this widespread cheap catalyst has also played an important role activation. This review focuses on copper involved assisted recent years, with the aim providing complementary existing reviews. Keywords: Carbon-carbon bonds, carbon-heteroatom groups,...

The asymmetric total syntheses of (+)-vulgarisins A-E, which share a rare and highly oxygenated [5-6-4-5] tetracyclic core structure that were isolated from P. vulgaris Linn., have been described for the first time in divergent manner. Key transformations include: 1) catalytic intramolecular cyclopropanation to forge A ring bearing desired stereochemistry at C14; 2) one-pot borylation/conjugate addition process creation C1-C11 bond; 3) Wolff contraction assemble bicyclo[3.2.0]heptane subunit...

A ring contraction approach for the total synthesis of (-)-pavidolide B was developed, which assembles this polycyclic natural product within 13 steps from known chiral alcohol 11. The key features strategy include (a) a double Mukaiyama-Michael addition/elimination, (b) ring-closing metathesis, (c) Wolff rearrangement, and (d) late-stage regioselective Schenck ene reaction.

The aging of many mammalian tissues is associated with loss functional adult stem cells, especially bone marrow-derived mesenchymal cells (BMSCs). This study was aimed to analyze the biological effect chick embryo (CE) and nutrient mixture (NM) on BMSCs rats. rat model established be induced by D-galactose (500 mg/kg/d) for 90 days. Meanwhile, rats were fed CE NM in different dose manner intragastric administration. At end experimental period, serum collected from used culture. Flow...

Noncoding RNAs (ncRNAs) are involved in the pathological processes of various diseases. The aim present study was to verify expression levels and diagnostic value two candidate ncRNAs blood leukocytes patients with gestational diabetes mellitus (GDM) compared healthy controls. long ncRNA paired box 8 antisense 1 (Pax8‑AS1) microRNA miR‑4646 were selected, which identified be associated GDM by bioinformatics analysis a dataset from Gene Expression Omnibus GEO database. By using reverse...

Abstract The asymmetric total syntheses of (+)‐vulgarisins A–E, which share a rare and highly oxygenated [5‐6‐4‐5] tetracyclic core structure that were isolated from P. vulgaris Linn., have been described for the first time in divergent manner. Key transformations include: 1) catalytic intramolecular cyclopropanation to forge A ring bearing desired stereochemistry at C14; 2) one‐pot borylation/conjugate addition process creation C1−C11 bond; 3) Wolff contraction assemble...

A metal- and hypervalent iodine reagent-free electrochemical oxidative dearomatization-induced [5+2] cycloaddition/pinacol rearrangement cascade reaction was described. The electrosynthetic method showed strong tolerance for vinylphenols, ethynylphenols, allenylphenols, which thus enabled the rapid assembly of diversely functionalized bicyclo[3.2.1]octanes in 41-95% yields up to >20:1 dr. This protocol could be scaled gram amounts should find wide application complex natural product synthesis.