A5070709833- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Mosquito-borne diseases and control
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Biotin and Related Studies
- Atherosclerosis and Cardiovascular Diseases
- Virology and Viral Diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Autism Spectrum Disorder Research
- Viral Infections and Vectors
- Cancer Research and Treatments
- CRISPR and Genetic Engineering
- HIV Research and Treatment
- Plant Disease Resistance and Genetics
- Malaria Research and Control
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Plant Virus Research Studies
- Plant Pathogens and Resistance
- RNA and protein synthesis mechanisms
University Medical Center Hamburg-Eppendorf
2022-2024
Universität Hamburg
2022-2024
Chinese Academy of Sciences
2016-2019
Institute of Computing Technology
2018-2019
State Key Laboratory of Computer Architecture
2018-2019
University of Chinese Academy of Sciences
2016-2019
Center for Excellence in Brain Science and Intelligence Technology
2016-2017
Institute of Genetics and Developmental Biology
2016-2017
Chinese Institute for Brain Research
2017
Genes implicated in translation control have been associated with autism spectrum disorders (ASDs). However, some important genetic causes of autism, including the 16p11.2 microdeletion, bear no obvious connection to translation. Here, we use proteomics, genetics, and assays cultured cells mouse brain reveal altered mediated by loss kinase TAOK2 deletion models. We show that associates translational machinery functions as a brake phosphorylating eukaryotic elongation factor 2 (eEF2)....
Lung cancer is a leading cause of mortality, highlighting the need for innovative non-invasive early detection methods. Although cell-free DNA (cfDNA) analysis shows promise, its sensitivity in early-stage lung patients remains challenge. This study aimed to integrate insights from epigenetic modifications and fragmentomic features cfDNA using machine learning develop more accurate model. To address this issue, multi-centre prospective cohort was conducted, with participants harbouring...
Studies have shown that microRNAs (miRNAs) play a vital role in tumor progression and patients' prognosis. Therefore, we aimed to construct miRNA model for forecasting the survival of hepatocellular carcinoma (HCC) patients. The gene expression data 433 patients with HCC from Cancer Genome Atlas (TCGA) Gene Expression Omnibus public databases were remined by analysis receptor manipulation characteristic curve (ROC). A prognostic including six miRNAs (hsa-mir-26a-1-3p, hsa-mir-188-5p,...
Abstract The abnormal expression of microRNAs (miRNAs) or protein‐coding genes (PCGs) have been found to be associated with the prognosis hepatocellular carcinoma (HCC) patients. Using bioinformatics analysis methods including Cox’s proportional hazards regression analysis, random survival forest algorithm, Kaplan–Meier, and receiver operating characteristic (ROC) curve we mined gene profiles 469 HCC patients from Cancer Genome Atlas ( n = 379) Gene Expression Omnibus (GSE14520; 90) public...
Adult human mesenchymal stem cells have the potential to differentiate into osteoblast, which plays crucial roles in bone regeneration and repair. Some transcriptional factors (TFs), such as BMP-2 RUNX2, been demonstrated control differentiation processes. It is important discover more key regulators osteoblast differentiation. Recently, some studies found long noncoding RNAs (lncRNAs) participating differentiation, MALAT1, DANCR, ANCR. In this study, we performed a network-based...
Abstract Glioblastoma (GBM) has become the most aggressive primary brain tumor in world. Patients with GBM usually have a poor prognosis. The median survival times of patients retain less than 2 years. Thus, it is urgent to investigate molecular mechanism GBM. Recently, studies demonstrated that transcription factors (TFs) participate cancer pathology by regulating long noncoding RNAs (lncRNAs). However, functional and regulatory roles TF‐lncRNA crosstalks are still unclear. In this study,...
With the increasing incidence of colorectal cancer (CRC) and continued difficulty in treating it using immunotherapy, there is an urgent need to identify effective immune-related biomarker associated with survival prognosis patients this disease. DNA methylation plays essential role maintaining cellular function, changes patterns may contribute development autoimmunity, aging, cancer. In study, we aimed a novel methylated signature aid predicting CRC. We investigated stage II/III CRC...
Manuscript summary There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID) to identify protein-protein interaction (PPI) for 41 ASD-risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, disrupted by de novo missense variants. The network map reveals convergent pathways, mitochondrial/metabolic processes, Wnt...
The mortality rate of hepatocellular carcinoma (HCC) remains high worldwide despite surgery and chemotherapy. Immunotherapy is a promising treatment for the rapidly expanding HCC spectrum. Therefore, it necessary to further explore immune-related characteristics tumour microenvironment (TME), which plays vital role in initiation progression.In this research, 866 differentially expressed genes (DEGs) were identified by integrating DEGs samples from Cancer Genome Atlas (TCGA)-HCC dataset...
Abstract Background : The percentage of death resulted from hepatocellular carcinoma (HCC) remains high worldwide, despite surgical and chemotherapy treatment. Immunotherapy offers great promise in the treatment a rapidly expanding spectrum HCC. Therefore, further exploration immune-related signatures tumor microenvironment, which plays vital role initiation progression for immunotherapy is currently needed. Methods: In this present research, 866 difference expression genes (DEGs) were...
Abstract Background : The percentage of death resulted from hepatocellular carcinoma (HCC) remains high worldwide, despite surgical and chemotherapy treatment. Immunotherapy offers great promise in the treatment a rapidly expanding spectrum HCC. Therefore, further exploration immune-related signatures tumor microenvironment, which plays vital role initiation progression for immunotherapy is currently needed. Methods: In this present research, 866 difference expression genes (DEGs) were...