A5101580455- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Esophageal Cancer Research and Treatment
- Sarcoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Congenital Diaphragmatic Hernia Studies
- Neuropeptides and Animal Physiology
- Dysphagia Assessment and Management
- Lung Cancer Research Studies
- Microtubule and mitosis dynamics
- Cancer Diagnosis and Treatment
- Eosinophilic Esophagitis
- Signaling Pathways in Disease
- Cardiac Imaging and Diagnostics
- Blood Coagulation and Thrombosis Mechanisms
- Orthodontics and Dentofacial Orthopedics
- Acute Myocardial Infarction Research
Affiliated Hospital of Hebei University
2014-2025
Wuxi Third People's Hospital
2023
Handan College
2014-2021
Affiliated Hospital of Nantong University
2020
Nantong University
2020
Second Affiliated Hospital of Nantong University
2020
Lanzhou University
2018
Hebei Medical University
2014
Polo-like kinase 1 (PLK1) has been suggested to serve as oncogene in most human cancers. The aim of our study is present more evidence about the clinical and prognostic value PLK1 lung squamous cell carcinoma patients. status was observed adenocarcinoma, normal tissues through analyzing microarray data set (GEO accession number: GSE1213 GSE 3627). mRNA protein expressions were detected by using qRT-PCR immunohistochemistry. In results, levels higher than that adenocarcinoma tissues. Compared...
Abstract Lung adenocarcinoma (LUAD) is the most common form of malignant tumor and closely correlated with high risk death worldwide. Accumulating researches have manifested that long noncoding RNAs (lncRNAs) are deeply involved in progression multiple cancers. LncRNA LOXL1 antisense RNA 1 (LOXL1‐AS1) was identified as an oncogene several cancers, nonetheless, its biological effect regulatory mechanism not been explained LUAD. Our present study suggested LOXL1‐AS1 expression considerably...
Lung cancer is the leading cause of death worldwide. Cisplatin major DNA-damaging anticancer drug that cross-links DNA in cells, but many patients inevitably develop resistance with treatment. Identification a cisplatin sensitizer might postpone or even reverse development resistance. Halofuginone (HF), natural small molecule isolated from Dichroa febrifuga , has been found to play an antitumor role. In this study, we HF inhibited proliferation, induced G0/G1 phase arrest, and promoted...
Lung cancer is a leading cause of mortality, highlighting the need for innovative non-invasive early detection methods. Although cell-free DNA (cfDNA) analysis shows promise, its sensitivity in early-stage lung patients remains challenge. This study aimed to integrate insights from epigenetic modifications and fragmentomic features cfDNA using machine learning develop more accurate model. To address this issue, multi-centre prospective cohort was conducted, with participants harbouring...
3051 Background: Cell-free DNA (cfDNA) extraction and circulating tumor (ctDNA) enrichment are critical for liquid biopsy-based cancer diagnostics. However, the QIAamp Circulating Nucleic Acid Kit (QIA), despite its widespread use, has limitations, including a labor-intensive manual workflow suboptimal performance in ctDNA marker contaminant removal, potentially affecting downstream methylation analyses. To overcome these we developed novel, automatable magnetic bead-based cfDNA method to...
BACKGROUND This study was designed to explore the correlations of promoter methylation in Wnt inhibitory factor-1 (WIF-1), ras-association domain family member 1A (RASSF1A), and Cadherin 13 (CDH13) genes with risk prognosis esophageal cancer (EC). MATERIAL AND METHODS A total 71 EC tissues from resection 35 adjacent normal were collected. Methylation status region detected by methylation- non-methylation-specific primers. Corresponding mRNA levels reverse transcriptase-polymerase chain...
Previous studies of the authors have indicated that transplantation mesenchymal stem cells (MSCs) can attenuate cardiac fibrosis through secretion antifibrotic factors, such as adrenomedullin (ADM). Therefore, addressed hypothesis ADM overexpression could enhance effect MSCs in a rat model heart failure. The results present study demonstrated that, compared with group received GFP‑MSCs, ADM‑MSCs significantly improved function and decreased percentage fibrotic area expression matrix...
Although osimertinib achieved convincing efficacy for patients with EGFR T790M-positive non-small-cell lung cancer (NSCLC) as second-line treatment in the AURA3 clinical trials, developed drug resistance ultimately. Therefore, present study was to investigate outcome and safety of plus anlotinib previously treated NSCLC.Designed a retrospective study, this consecutively included total 33 advanced NSCLC who possessed mutation progressed after first-line therapy. Eligible were anlotinib....
Emerging evidence has suggested that inherited factors are also involved in lung cancer development. However, most studies focused on well-elucidated predisposition genes, the majority of which tumor suppressor genes. The profile germline mutations oncogenic driver genes remains unrevealed, might provide potential clinical implications for management.Sequencing data from 36,813 unselected patients who underwent somatic mutation profiling were retrospectively reviewed. All recruited had...
MicroRNA-34a (miR-34a) plays an essential role in regulating blood lipid, inflammation, cell adhesion molecules, and atherosclerosis, the latter factors are closely involved etiology of coronary heart disease (CHD). However, clinical value miR-34a CHD patients' management is rarely reported. Hence, this study aimed to assess correlation with risk, artery stenosis, inflammatory cytokines, molecules CHD.A total 203 patients 100 controls were recruited study, then their plasma samples collected...
Esophageal squamous cell carcinoma (ESCC) consistently ranks as one of the most challenging variants carcinomas, primarily due to lack effective early detection strategies. We herein aimed elucidate underlying mechanisms and biological role associated with A-kinase anchoring protein 12 (AKAP12) in context ESCC. Bioinformatic analysis had revealed significantly lower expression level AKAP12 ESCC tissue samples than their non-cancerous counterparts. To gain deeper insights into potential...
Serotonin (5-HT) is a neurotransmitter and vasoactive amine that involved in the regulation of large number physiological functions. The wide variety 5-HT-mediated functions due to existence different classes serotonergic receptors mammalian gastrointestinal tract nervous system. aim this study was explore expression multiple types 5-HT receptor (5-HT1AR, 5-HT2AR, 5-HT3AR, 5-HT4R, 5-HT5AR, 5-HT6R 5-HT7R) sling clasp fibers from human lower esophageal sphincter (LES). Muscle strips LES were...
Background: Occlusal splint therapy, which is a conservative approach to treat temporomandibular disorders (TMDs) and bruxism, can change the occlusal contact of dentition. However, little known about variation in bite force joint (TMJ) sounds. The objective this case report compare effects different thicknesses constructed by vacuum lamination technology on function TMJ Clinical Presentation: This study presents 24-year-old male with bruxism. Four splints (0.6 mm, 1 2.5 mm 3 mm) were...
BACKGROUND:Proliferation and migration play crucial roles in various physiological processes, especially injured endothelial repair. Endothelial progenitor cells (EPCs), as the precursors of cell, are involved regeneration lining blood vessels. Furthermore, EPCs were found to be a potential choice for venous thrombosis (VT) treatment. MATERIAL AND METHODS:EPCs isolated from human peripheral healthy adults VT patients. Differently expressed micro(mi)RNAs examined by quantitative real-time...
<p class="Abstract">It was aimed to explore the expression level of miRNA-486 and miRNA-499 in plasma lung cancer patients analysis their differences expre-ssion. The both non-small cell (NSCLC) small (SCLC) were lower than that control group (p&lt;0.05) decrease more obvious NSCLC. Compare with miRNA-499，expression quantity NSCLC plasma. There statistical significance difference between III～Ⅳstage I～II stage. miRNA extensive-stage SCLC limited-stage (p&lt;0.05). sensitivity...
Lung adenocarcinoma is the most common subtype of non-small cell lung cancer (NSCLC). Hyperplasia suppressor gene (HSG) has been reported to inhibit proliferation, migration, and remodeling in cardiovascular diseases. However, there lacks systematic researches on effect HSG apoptosis proliferation A549 cells data vivo experiments. The present study aims investigate effects silencing cells. human was selected construct adenovirus vector. Reverse transcription-quantitative PCR (RT-qPCR)...
This study investigated the role of micro ribonucleic acid (miR)-129 in non-small cell lung cancer (NSCLC) by examining its effects on proliferation and apoptosis, as well relationship with high-mobility group AT-hook 2 (HMGA2) target gene. Human NSCLC tissues were collected, cancerous cells normal isolated cultured. In vitro cultured transfected miR-129 mimics or HMGA2-small interfering RNA (siRNA). The expression levels HMGA2 measured using quantitative reverse transcription-polymerase...
e22507 Background: Methylation-based sequencing has been developed as a promising approach for Multi-Cancer Early Detection (MCED). Conventionally, cancer-specific methylation markers were identified by comparing paired tumor and adjacent normal tissues using traditional algorithm DSS (Dispersion shrinkage data). However, the clinical applicability is limited unsatisfactory sensitivity in early-stage disease. Hence, we included blood specific derived from tissue samples novel fragment-based...
To investigate the effects of standard two-field lymph node dissection (2FLND) and total 2FLND on short-term long-term clinical efficacy complications patients undergoing esophagectomy.The data 268 radical Ivor-Lewis esophagectomy in our hospital from January 2008 to November 2015 were analyzed retrospectively. According different methods (LND), divided into group (n = 121) 147). The LND status, postoperative complications, survival rate recurrence two groups analyzed.Lymph metastasis showed...
Abstract: Estimated to comprise approximately 10% of lung cancer cases, multiple pulmonary lesions pose a diagnostic and therapeutic challenge in thoracic oncology. Distinction between primary (MPLC) intrapulmonary metastasis (IPM) directly affects tumor staging clinical management. In equivocal cases which the are histopathologically indistinguishable, targeted sequencing can provide key additional evidence for differential diagnosis. Herein, we describe an unusual patient who presented...
Primary pulmonary sarcoma (PPS) is very rare relative to other subtypes of lung cancer. Therefore, evidence-based treatment options for PPS patients have remained unclear. Identification actionable cancer driver mutations in with non-small cell (NSCLC) has provided the chance use targeted treatments and improve patient clinical outcomes. In addition epidermal growth factor receptor (EGFR), wide high-throughput genomic profiling next-generation sequencing (NGS) also identified genes such as...
Objective To compare the egicacy and security of intracoronary administration tirofiban combined high-dose adenosine during percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (STEMI).Methods Eighty-eight cases STEMI were randomly divided into observation group(44 cases) who accepted 2 times adenosine(2 mg,10 ml 0.9％ NaCl),and control afforded only 10 NaCl by prospective,double-blind,and random study.The two groups received10 g/kg after aspiration catheter...