A5103192144- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Medicinal Plant Pharmacodynamics Research
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- HER2/EGFR in Cancer Research
Handan College
2021
PURPOSE This study aimed to investigate the changes in microRNA-130a (miR-130a) and its correlation with cardiotoxicity during epirubicin/cyclophosphamide followed by docetaxel plus trastuzumab (EC-D+T) adjuvant chemotherapy human epidermal growth factor receptor-2-positive (HER2⁺) breast cancer patients. METHODS A total of 72 HER2⁺ patients who underwent resection were scheduled receive EC-D+T therapy consecutively enrolled. The expression miR-130a (defined as any following situations: 1)...
MicroRNA-34a (miR-34a) plays an essential role in regulating blood lipid, inflammation, cell adhesion molecules, and atherosclerosis, the latter factors are closely involved etiology of coronary heart disease (CHD). However, clinical value miR-34a CHD patients' management is rarely reported. Hence, this study aimed to assess correlation with risk, artery stenosis, inflammatory cytokines, molecules CHD.A total 203 patients 100 controls were recruited study, then their plasma samples collected...