A5102956916- Pharmaceutical and Antibiotic Environmental Impacts
- Microplastics and Plastic Pollution
- Photonic Crystal and Fiber Optics
- Immune Cell Function and Interaction
- Advanced Fiber Laser Technologies
- RNA Research and Splicing
- Advanced Fiber Optic Sensors
- NF-κB Signaling Pathways
- Laser-Matter Interactions and Applications
- Ubiquitin and proteasome pathways
- Photonic and Optical Devices
- interferon and immune responses
- Guidance and Control Systems
- Adaptive Control of Nonlinear Systems
- Cancer-related molecular mechanisms research
- Solid State Laser Technologies
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Kruppel-like factors research
- Photorefractive and Nonlinear Optics
- Environmental DNA in Biodiversity Studies
- Marine and coastal ecosystems
- Angiogenesis and VEGF in Cancer
- Stability and Control of Uncertain Systems
Affiliated Hospital of Hebei University
2015-2025
Shanghai Maritime University
2021-2025
Shandong Normal University
2025
Guangzhou Medical University
2024
Hebei Medical University
2006-2024
East China Normal University
2019-2024
Huazhong University of Science and Technology
2005-2024
Wuhan National Laboratory for Optoelectronics
2019-2024
First Affiliated Hospital of Guangzhou Medical University
2024
Nantong University
2023
Municipal landfill leachate is a huge reservoir of (nano)microplastics (N/MPs) and antibiotic resistance genes (ARGs).
The dissemination and propagation of antibiotic resistance genes (ARGs) is an emerging global health concern, the potential effects nanomaterials on ARGs fates have drawn much attention recently. In current study, metallic nanoparticles occurrence leachate culturable microbiota were investigated by four typical metal oxide (Cu, Zn, CuO, ZnO). diversity was remarkably decreased during cultivation enrichment microbiota, their abundances for 1.4–3.2 orders magnitude. presence facilitated...
The functional integrity of Treg cells is interwoven with cellular metabolism; however, the mechanisms governing cell metabolic programs remain elusive. Here, we identified that deubiquitinase USP47 inhibited RNA m6A reader YTHDF1-mediated c-Myc translation to maintain and homeostasis. positively correlated tumor-infiltrating signature in colorectal cancer gastric patient samples. ablation compromised homeostasis function vivo, resulting development inflammatory disorders, boosted antitumor...
OTUD7B, a multifunctional deubiquitinylase, plays essential role in inflammation and proliferation signals. However, its function lung cancer remains largely unknown. The aim of this study was to evaluate the prognostic significance OTUD7B patients with adenocarcinoma squamous carcinoma characterize molecular mechanisms progression metastasis. Two tissue microarrays containing 150 pairs matched adjacent non-cancer tissues one microarray 75 were included immunohistochemical staining performed...
Disrupted mitochondrial function and reactive oxygen species (ROS) generation cause cellular damage oxidative stress-induced macrophage inflammatory cell death. It remains unclear how dysfunction relates to inflammasome activation pyroptotic In this study, we demonstrated that tumor necrosis factor receptor-associated 3 (TRAF3) regulates ROS production promotes TLR agonist LPS plus nigericin (LPS/Ng)-induced pyroptosis in mouse primary macrophages human monocyte THP-1 cells. Co-IP assays...
Triple-negative breast cancer (TNBC), the most aggressive subtype of cancer, is associated with high invasiveness, metastatic occurrence and poor prognosis. Protein tyrosine kinase 7 (PTK7) plays an important role in multiple cancers. However, PTK7 TNBC has not been well addressed. This study was performed to evaluate progression TNBC.Correlation expression clinicopathological parameters assessed using tissue microarray immunohistochemistry (IHC) staining 280 patients cancer. (MDA-MB-468,...
Abstract TRK-fused gene (TFG) is known to be involved in protein secretion and plays essential roles an antiviral innate immune response. However, its function LPS-induced inflammation pyroptotic cell death still unknown. Here, we reported that TFG promotes the stabilization of Unc-51 like autophagy activating kinase (ULK1) participates LPS plus nigericin (Ng) induced death. Our results showed TFG-deficient THP-1 macrophages exhibit higher mitochondrial ROS production. LPS/Ng stimulation...