A5036359747- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Acute Ischemic Stroke Management
- Amyotrophic Lateral Sclerosis Research
- Cardiovascular Syncope and Autonomic Disorders
- Neurological Disease Mechanisms and Treatments
- Retinal Imaging and Analysis
- Dementia and Cognitive Impairment Research
- MicroRNA in disease regulation
- Trace Elements in Health
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- RNA regulation and disease
- Vascular Malformations Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Prion Diseases and Protein Misfolding
- Peripheral Artery Disease Management
- Extracellular vesicles in disease
- Neurological Disorders and Treatments
- Advanced MRI Techniques and Applications
- Neurogenetic and Muscular Disorders Research
- Functional Brain Connectivity Studies
- Cholinesterase and Neurodegenerative Diseases
- Trigeminal Neuralgia and Treatments
Hunan University
2023-2025
University of South China
2021-2022
Huaian First People’s Hospital
2021-2022
Xiangya Hospital Central South University
2016-2019
Central South University
2016-2019
Neurology, Inc
2019
Background: A growing body of evidence indicates alterations in metabolite levels and enzyme activities associated with the conversion tryptophan (TRP) throughout course cerebral ischemia. In this study we aim to explore potential relationship between TRP metabolism clinical prognosis acute ischemic stroke (AIS) patients mainland China. Methods: Blood samples were obtained from a cohort 304 AIS patients. The concentrations ten metabolites quantified utilizing liquid chromatography-tandem...
Objective Renal artery stenosis (RAS) which is a potentially reversible cause of hypertension and renal insufficiency associated with poor prognosis in ischemic stroke patients. The inter-arm blood pressure difference (IABD) independently related to the atherosclerosis arteries. This study was evaluate relationship RAS IABD Materials methods cross-sectional observational consecutive patients who had not history RAS. Abdominal aortography performed screen for after cerebrovascular diagnostic...
The prion protein (PRNP) gene is associated with diseases, whereas variants of the PRNP may also explain some cases Alzheimer disease (AD) and frontotemporal dementia (FTD) in Caucasian populations. To determine prevalence patients AD FTD China, we screened all exons a cohort 683 (606 77 FTD) Chinese Han population detected novel missense mutation p.S17G late-onset (LOAD) patient. Furthermore, analyzed M/V polymorphism at codon 129, which was previously reported as risk factor. However,...
Mutations of the cyclin F (CCNF) gene were recently identified to be associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in Western Japanese populations. The rare protein-altering variants frequency is 0.6 3.3% ALS FTD from these diverse geographic populations while no systematic analysis CCNF conducted Chinese population. We screened all exons a cohort 269 cases (including 181 88 FTD) Mainland China using Sanger sequencing. A heterozygous variant (c.481G >...
Objective: To explore the value of multiple visual rating scales based on structural MRI in diagnosis Alzheimer’s disease (AD) Chinese population. Materials and Methods: One hundred patients with AD 100 age- gender- matched cognitively normal controls were enrolled this study. All participants underwent neuropsychological tests a scan brain, among them, 42 cases 47 also 3D-T1 weighted sequence used for analysis voxel-based morphometry (VBM). The divided into mild moderate–severe groups...
Objective Orthostatic hypotension (OH) which diagnosis is based on the measurement of blood pressure response to orthostatism (BPRO) a common condition associated with adverse cerebrovascular and cognitive prognosis. It likely that single might underestimate true prevalence OH. This study investigated reproducibility OH related risk factors in hospitalized acute ischemic stroke (AIS) patients multiple measurements. Materials methods was prospective cohort analysis consecutive AIS admitted...
Recently, the coiled‑coil‑helix‑coiled‑coil‑helix domain 2 (CHCHD2) gene was identified as a possible causative for Parkinson's disease (PD). Three other neurodegenerative diseases, Alzheimer's (AD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), share significant overlaps with PD in clinical phenotypes, pathological features genetic heredities, it is still unclear whether CHCHD2 variants could explain these three diseases. The present study screened all exons of...
Objective Translocase of outer mitochondrial membrane 40 (TOMM40) encodes translocase the (TOM), which is associated with dysfunction in Alzheimer’s disease (AD). TOMM40 rs157581-G has been reported to increase susceptibility AD. However, effect resting-state functional MRI (rs-fMRI) on AD not studied. Therefore, we aimed investigate role rs-fMRI results patients. Methods Twenty-four patients were divided into two groups based status, and clinical imaging data compared between groups....
Objective The clinical management of patients with acute ischemic stroke (AIS) is complicated by orthostatic hypotension, which might have close relationship the atherosclerosis cerebral arteries. primary objectives were to evaluate hypotension extracranial carotid arteries (ECAS) and intracranial (ICAS) in AIS patients. Methods This study was a prospective cohort analysis consecutive under cerebrovascular angiography. A total 289 included. defined as systolic BP decline ≥20 mmHg or...
White matter hyperintensity (WMH) burden is associated with a higher risk of ischemic stroke. The relationship between WMH and obesity somewhat controversial which might be interfered by different body composition such as skeletal muscle, fat bone density. However, few researchers have evaluated the disaggregated constituents in acute stroke (AIS) patients systematically. A total 352 AIS were enrolled this study. subcutaneous adipose tissue, erector spinae muscle area density on computed...
To explore the value of multiple visual rating scales based on structural MRI in diagnosis Alzheimer's disease (AD) Chinese population. One hundred patients with AD and 100 age- gender- matched cognitively normal controls were enrolled this study. All participants underwent neuropsychological tests a scan brain, among them, 42 cases 47 also 3D-T1 weighted sequence used for analysis voxel-based morphometry (VBM). The divided into mild moderate–severe groups according to mini-mental state...
Spontaneous carotid cavernous fistula (CCF) is rare, and the expression of headache caused by it can be variable.A case a man hospitalized for high-intensity hemicranial which was aggravated lying down relieved when standing or sitting. The pain pulsating character, localized on right, behind eye, followed nausea vomiting. He gradually appeared with ophthalmoplegia, decreased visual acuity epistaxis.Digital subtraction angiogram (DSA) showed pseudoaneurysm arising from internal artery (ICA)...