A5101701502- Alzheimer's disease research and treatments
- GDF15 and Related Biomarkers
- Nuclear Receptors and Signaling
- Bioinformatics and Genomic Networks
- Dementia and Cognitive Impairment Research
- Cerebrovascular and genetic disorders
- Amyotrophic Lateral Sclerosis Research
- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Gut microbiota and health
- Genetic Neurodegenerative Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Plant nutrient uptake and metabolism
- Genetics and Neurodevelopmental Disorders
- Plant Molecular Biology Research
- Moyamoya disease diagnosis and treatment
- Postharvest Quality and Shelf Life Management
- Parkinson's Disease Mechanisms and Treatments
- CAR-T cell therapy research
- Nutrition, Genetics, and Disease
- Oral microbiology and periodontitis research
- Functional Brain Connectivity Studies
- Salivary Gland Disorders and Functions
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
Xiangya Hospital Central South University
2018-2023
Central South University
2018-2023
China National Rice Research Institute
2023
First Affiliated Hospital of Zhengzhou University
2021
Henan Academy of Sciences
2021
Zhengzhou University
2021
Abstract Background Electroencephalogram (EEG) has emerged as a non-invasive tool to detect the aberrant neuronal activity related different stages of Alzheimer’s disease (AD). However, effectiveness EEG in precise diagnosis and assessment AD its preclinical stage, amnestic mild cognitive impairment (MCI), yet be fully elucidated. In this study, we aimed identify key biomarkers that are effective distinguishing patients at early stage monitoring progression AD. Methods A total 890...
Chilling stress seriously limits grain yield and quality worldwide. However, the genes underlying mechanisms that respond to chilling remain elusive. This study identified ABF1, a cold-induced transcription factor of bZIP family. Disruption ABF1 impaired tolerance with increased ion leakage reduced proline contents, while over-expression lines exhibited opposite tendency, suggesting positively regulated in rice. Moreover, SnRK2 protein kinase SAPK10 could phosphorylate strengthen DNA-binding...
To investigate the impact of rare variants underlying neurodegenerative-related genes to familial Alzheimer's disease (AD).We performed targeted sequencing 277 on probands from 75 Chinese AD families non-carrying causative mutation dementia genes. Rare coding segregated in were tested for association an independent cohort 506 patients with sporadic and 498 cognitively normal controls. East Asians data Exome Aggregation Consortium (ExAC) used as a reference control.A novel variant, P410S PLD3...
Abstract Aims NOTCH3 gene mutations predominantly cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, a common etiology of vascular dementia (SVaD). Besides, there may be pathogenic link between variants Alzheimer's disease (AD). We aimed to study the role in AD SVaD patients. Methods recruited 763 patients (667 96 SVaD) 365 healthy controls from Southern Han Chinese population. Targeted capture sequencing was performed on coding adjacent intron...
Follicular regulatory T cells (Tfr) have critical functions in inflammatory and autoimmune disorders. The main purpose of the current work was to assess Tfr cell frequency patients with dilated cardiomyopathy (DCM). Flow cytometry showed that, compared normal controls, DCM cases markedly reduced rates Tfr/Tfh ratios, but significantly increased follicular helper (Tfh) rates. Correlation analysis that rate positively correlated left ventricular ejection fraction (LVEF), negatively N-terminal...
The role of vascular dementia (VaD)-associated genes in Alzheimer's disease (AD) remains elusive despite similar clinical and pathological features. We aimed to explore the relationship between these AD Chinese population.Eight VaD-associated were screened by a targeted sequencing panel sample 3604 individuals comprising 1192 patients 2412 cognitively normal controls. Variants categorized into common variants rare according minor allele frequency (MAF). Common variant (MAF ≥ 0.01)-based...
The genes involved in the metabolic pathways of amyloid-β (Aβ) and tau proteins significantly influence etiology Alzheimer’s disease (AD). Various studies have explored associations between some these AD Caucasian population; however, researches regarding remain limited Chinese population. To systematically evaluate with AD, we investigated 19 metabolism Aβ based on previous selected using PubMed database. This study included 372 patients sporadic late-onset (sLOAD) 345 cognitively healthy...
Recently, the coiled‑coil‑helix‑coiled‑coil‑helix domain 2 (CHCHD2) gene was identified as a possible causative for Parkinson's disease (PD). Three other neurodegenerative diseases, Alzheimer's (AD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), share significant overlaps with PD in clinical phenotypes, pathological features genetic heredities, it is still unclear whether CHCHD2 variants could explain these three diseases. The present study screened all exons of...
Recent studies found that poor oral hygiene was associated with increased risk of dementia, even the number bacteria significantly in brain tissues patients Alzheimer's disease (AD), suggesting microbiota may play an important role pathogenesis AD. However, actual composition communities AD and whether it is severity APOE genotype remain largely unknown. A total 78 subjects were recruited this study, including 39 healthy controls. Saliva collected from each subject.16S ribosomal RNA...
Abstract Background Mutations of APP , PSEN1 and PSEN2 only account for a small portion familial Alzheimer’s disease (AD), leaving the genetic factors rest AD families unexplained. Neurodegenerative diseases have some neuropathological, clinical crossover. The effect neurodegenerative genes to remains unknown. We hypothesized that rare variants may lead family aggregation AD. aim study was investigate Methods Targeted sequencing 277 performed on probands from 75 Chinese origin. Rare coding...
Vitamin D insufficiency has been implicated as a risk factor for Alzheimer disease (AD) in several studies. Recently, 4 single nucleotide polymorphisms (SNPs) to be genome-wide significant 25(OH)D were identified have association with of AD. These include rs2282679 GC, rs10741657 near CYP2R1, rs12785878 DHCR7 and rs6013897 CYP24A1. But whether the SNPs account risks Chinese AD remains unknown. A case–control cohort study was conducted 533 patients 551 normal controls. Genotyping determined...