A5101485246- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Calpain Protease Function and Regulation
- Optical Imaging and Spectroscopy Techniques
- Phytase and its Applications
- Dementia and Cognitive Impairment Research
- Folate and B Vitamins Research
- Protein Hydrolysis and Bioactive Peptides
- Skin and Cellular Biology Research
- Nuclear Receptors and Signaling
- Mycobacterium research and diagnosis
- Respiratory and Cough-Related Research
- Tryptophan and brain disorders
- Prion Diseases and Protein Misfolding
- Pediatric health and respiratory diseases
- Inflammation biomarkers and pathways
- Genetics and Neurodevelopmental Disorders
Xiangya Hospital Central South University
2014-2025
Central South University
2014-2025
Soil and Fertilizer Institute of Hunan Province
2020
Changsha Medical University
2014
Guangzhou Medical University
2012
Abstract Background Ethnic variations and detection methods may lead to differences in diagnostic biomarkers of dementia, few comparative studies have evaluated the six plasma Alzheimer’s disease (AD) other neurodegenerative dementias Chinese population. Methods A cross-sectional cohort 668 participants were enrolled, including 245 amnesic mild cognitive impairment (aMCI) or AD patients with Aβ positive pathology, 67 frontotemporal dementia (FTD), 100 progressive supranuclear palsy (PSP), 72...
Genetic variations in the vacuolar protein sorting 10 (Vps10p) family have been linked to Alzheimer's disease (AD). Here we demonstrate deposition of fragments from Vps10p sortilin at senile plaques (SPs) aged and AD human cerebrum. Sortilin changes were characterized postmortem brains with antibodies against extracellular intracellular C-terminal domains. The two exhibited identical labeling normal cerebrum, occurring somata dendrites cortical hippocampal neurons. antibody also marked...
To investigate the impact of rare variants underlying neurodegenerative-related genes to familial Alzheimer's disease (AD).We performed targeted sequencing 277 on probands from 75 Chinese AD families non-carrying causative mutation dementia genes. Rare coding segregated in were tested for association an independent cohort 506 patients with sporadic and 498 cognitively normal controls. East Asians data Exome Aggregation Consortium (ExAC) used as a reference control.A novel variant, P410S PLD3...
Abstract INTRODUCTION Frontotemporal dementia (FTD) is characterized by phenotypic and genetic heterogeneities. However, reports on the large Chinese FTD cohort are lacking. METHODS Two hundred forty‐eight patients with were enrolled. All 2010 healthy controls underwent next generation sequencing. Plasma samples analyzed for glial fibrillary acidic protein (GFAP), α‐synuclein (α‐syn), neurofilament light chain (NfL), phosphorylated tau 181 (p‐tau181). RESULTS Gene sequencing identified 48...
Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis Alzheimer's disease (AD). However, genetic LGMN AD has not been clearly elucidated. Here, we used Sanger sequencing to investigate single independent (single-variant association test) cumulative (gene-based effects variants gene as potential susceptibility factors...
Abstract Background Various studies indicated that the immune system is a cardinal feature of Alzheimer’s disease (AD), which can either ameliorate or exacerbate AD neuropathogenesis. Nevertheless, associations between genes involved in and remain unclear. Method To systematically evaluate these with AD, we investigated 370 implicated based on previous selected using PubMed database. Our study recruited 1511 patients 2001 cognitively normal controls. were sequenced targeted panel. Variants...
Abstract Background Aging exhibits significant variation among individuals, with biological age as a more reliable predictor of current health status compared to chronological age. Predicting is crucial for facilitating timely interventions aimed at improving the adaptation aging process. Given intricate and multifactorial nature aging, scientific approach involves constructing prediction model that incorporates multiple dimensions systematically. Method This study enrolled 908 non‐dementia...
Abstract Background Frontotemporal dementia (FTD) exhibits clinical phenotypic and genetic heterogeneity. However, reports on the characteristics frequency of mutations in large‐sample Chinese populations with FTD are lacking. Furthermore, diagnostic performance plasma neurodegenerative biomarkers remains unclear. Method This study included 245 clinically diagnosed patients for an analysis characteristics. All 1,000 gender‐ age‐matched healthy controls underwent targeted gene sequencing or...