A5013053628- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Developmental Biology and Gene Regulation
- COVID-19 epidemiological studies
- Single-cell and spatial transcriptomics
- SARS-CoV-2 detection and testing
- Ubiquitin and proteasome pathways
- Bacteriophages and microbial interactions
- Cosmology and Gravitation Theories
- Zebrafish Biomedical Research Applications
- Long-Term Effects of COVID-19
- Dark Matter and Cosmic Phenomena
- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- Circadian rhythm and melatonin
- Amino Acid Enzymes and Metabolism
- Amyotrophic Lateral Sclerosis Research
- Cancer Research and Treatments
- Prion Diseases and Protein Misfolding
- Particle physics theoretical and experimental studies
- vaccines and immunoinformatics approaches
- Microbial infections and disease research
- COVID-19 diagnosis using AI
- Immune responses and vaccinations
- Neurobiology and Insect Physiology Research
National Institute for Viral Disease Control and Prevention
2020-2024
Princeton University
2010-2023
Chinese Academy of Sciences
2020-2021
Xinjiang Uygur Autonomous Region Education Department
2021
Chinese Center For Disease Control and Prevention
2015
<abstract abstract-type="Abstract"> <sec> <b>Introduction</b> The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has generated 2,431 variants over the course of its global transmission past 3 years. To better evaluate genomic variation SARS-CoV-2 before and after optimization disease 2019 (COVID-19) prevention control strategies, we analyzed genetic evolution branch composition in both domestic imported cases China (the data from Hong Kong Macau Special Administrativc Regions...
Proteomics changes of brain tissues have been described in different neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. However, the proteomics human prion remains less understood. In study, patterns cortex cerebellum sporadic Creutzfeldt-Jakob disease, fatal familial insomnia, G114V genetic CJD were analyzed with isobaric tags for relative absolute quantitation combined multidimensional liquid chromatography MS analysis, brains from three normal individuals as...
Some Ciona neurons show transcriptional similarities to the mouse hypothalamus, suggesting that it predates vertebrates.
The CNS of the protovertebrate Ciona intestinalis contains a single cluster dopaminergic (DA) neurons, coronet cells, which have been likened to hypothalamus vertebrates. Whole-embryo single-cell RNA sequencing (RNA-seq) assays identified Ptf1a as most strongly expressed cell-specific transcription factor (TF) in DA/coronet cells. Knockdown activity results their loss, while misexpression appearance supernumerary Photoreceptor cells and ependymal are susceptible transformation, both cell...
Starting from December 2019, Wuhan, China, encountered the first outbreak of coronavirus disease 2019 (COVID-19) (1-2).The epidemic was successfully suppressed by strict containment so that number infected people reduced to 0 on April 8, 2020 (3-4).After that, China experienced roughly 3 dozen outbreaks with local transmission caused imported severe acute respiratory syndrome 2 (SARS-CoV-2).These were then contained an effective suppression strategy, and has reached zero again.However,...
Cryogenic noble liquid detectors are presently considered one of the best options for WIMP Dark Matter searches, especially when extensions to multi ton scale sensitive masses foreseen. The WArP experiment is first that exploits unique characteristics Argon make a highly search candidates. In 2008, double phase detector has been assembled in Gran Sasso National Laboratory with 140 kg mass and discovery potential range 5 × 10-45 cm2 spin-independent WIMP-nucleon cross-section. addition...
Thalidomide has a dark history as teratogen, but in recent years, its derivates have been shown to function potent chemotherapeutic agents. These drugs bind cereblon (CRBN), the substrate receptor of an E3 ubiquitin ligase complex, and modify degradation targets. Despite these insights, remarkably little is known about normal development. Here, we employ Ciona , simple invertebrate chordate, identify endogenous Crbn In Ciona, specifically expressed developing muscles during tail elongation...
Cryogenic noble liquid detectors are presently considered one of the best options for WIMP Dark Matter searches, especially when extensions to multi ton scale sensitive masses foreseen. The WArP experiment is first that exploits unique characteristics Argon make a highly search candidates. In 2008, double phase detector has been assembled in Gran Sasso National Laboratory with 140 kg mass and discovery potential range 5 × 10−45 cm2 spin-independent WIMP-nucleon cross-section. addition...
As of February 22, a total 198 confirmed COVID-19 cases were reported in Harbin, Heilongjiang Province, and no new local Harbin over the next 54 days (1).However, on April 9, newly case was with an unknown source infection (2).The patient, 54-year-old male, developed fever March 28 highest recorded temperature at 37.5 ℃.On 7, symptoms worsened included dyspnea, cough, sputum, chest pain, other symptoms, though he did not experience distress, heart palpitations, nausea vomiting, abdominal...
Before the coronavirus disease 2019 (COVID-19) outbreak on July 16, 2020, no new COVID-19 cases were reported in Urumqi City of Xinjiang for 150 consecutive days.During this outbreak, 826 confirmed have been Urumqi.The phylogenetic characteristics virus from clinical specimens initial 4 sequenced.The full-length genome sequencing was performed Illumina MiSeq platform, and sequences obtained outbreak.Compared with reference sequence EPI_ISL_402119 (1), which isolated Wuhan Hubei Province...
The causative agent of coronavirus disease 2019 (COVID-19), known as severe acute respiratory syndrome 2 (SARS-CoV-2), has spread accumulatively to 240 countries and continues evolve. To gain a comprehensive understanding the epidemiological characteristics imported variants in China their correlation with global circulating variants, genomic surveillance data from 11 139 COVID-19 cases submitted by Chinese provincial CDC laboratories between 2021 2022 were analyzed. Consensus sequences...
ABSTRACT Thalidomide has a dark history as teratogen, but in recent years it been shown to function chemotherapeutic agent. binds cereblon, component of E3 ubiquitin ligase complex and modifies its degradation targets. Despite these insights, remarkably little is known about the normal cereblon development. Here, we employ simple proto-vertebrate model, Ciona intestinalis , address this question. We observed “hotspot” Crbn expression developing tail muscles identify enhancer containing both...
According to the Pango nomenclature, a total of 1 379 lineages SARS-CoV-2 have been identified worldwide as 20 September 2021. Some disappeared or are close disappearing due replacement by variants with higher transmissibility and/or immune escape ability. The World Health Organization (WHO) has defined 4 concern (VOC), 5 interest (VOI) and 11 belonging under monitoring (VUM). At present, Delta variant replaced Alpha predominant global pandemic strain, it is also main detected in imported...