A5101992000- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Ideological and Political Education
- Liver Diseases and Immunity
- Drug Transport and Resistance Mechanisms
- Flavonoids in Medical Research
- Immune Cell Function and Interaction
- Inflammatory Bowel Disease
- Diet, Metabolism, and Disease
- MRI in cancer diagnosis
- Galectins and Cancer Biology
- Pancreatitis Pathology and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Nuclear Receptors and Signaling
- Online and Blended Learning
- Education, Sociology, Communication Studies
- Higher Education and Teaching Methods
- Atherosclerosis and Cardiovascular Diseases
- Education and Work Dynamics
- Innovative Educational Techniques
- Kruppel-like factors research
- Immunodeficiency and Autoimmune Disorders
- Heart Rate Variability and Autonomic Control
- Educational Reforms and Innovations
NGM Biopharmaceuticals (United States)
2014-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Chengdu Medical College
2011
Changzhou University
2006-2008
Zhejiang Radio and Television University
2008
Nontumorigenic FGF19 variants represent an effective approach for the prevention and treatment of cholestatic liver diseases.
Bile acid nuclear receptor farnesoid X (FXR) is a key molecular mediator of many metabolic processes, including the regulation bile acid, lipid and glucose homeostasis. A significant component FXR-mediated events essential to its biological activity attributed induction enteric endocrine hormone fibroblast growth factor (FGF)19 or rodent ortholog, FGF15. In this report, we compared properties human FGF19 murine FGF15 in hepatocarcinogenesis metabolism various mouse models...
BackgroundDisruption of bile acid (BA) homeostasis plays a key role in intestinal inflammation. The gut-liver axis is the main site for regulation BA synthesis and pool size via combined action nuclear Farnesoid X Receptor (FXR) enterokine Fibroblast Growth Factor 19 (FGF19). Increasing evidence have linked derangement metabolism with dysbiosis mucosal Thus, here we aimed to investigate potential an FGF19 analogue on microbiota inflammation.MethodsA novel engineered non-tumorigenic variant...
Background and aim Bile acid (BA) synthesis in the liver is regulated by Fibroblast Growth Factor 19 (FGF19) secreted from ileum as an enterohepatic feedback mechanism. Although FGF19 mRNA absent normal liver, gene expression was reported to increase response both extrahepatic intrahepatic cholestasis. The impact of upregulated on BA unclear overall role circulating under cholestatic conditions needs be further investigated. Methods directly quantified measuring serum concentrations...
Abstract Suppressive myeloid cells inhibit antitumor immunity by preventing T-cell responses. Immunoglobulin-like transcript 3 (ILT3; also known as LILRB4) is highly expressed on tumor-associated and promotes their suppressive phenotype. However, the ligand that engages ILT3 within tumor microenvironment renders unknown. Using a screening approach, we identified fibronectin functional for ILT3. The interaction of with polarized toward state, these effects were reversed an ILT3-specific...
Critical regulation of bile acid (BA) pool size and composition occurs via an intensive molecular crosstalk between the liver gut, orchestrated by combined actions nuclear Farnesoid X receptor (FXR) enterokine fibroblast growth factor 19 (FGF19) with final aim reducing hepatic BA synthesis in a negative feedback fashion. Disruption homeostasis increased toxic levels leads to higher incidence hepatocellular carcinoma (HCC). While native FGF19 has anti-cholestatic anti-fibrotic activity liver,...
Objective To explore the significance and scheme of OSCE ( structural clinical examination ) applied in resident training examination. Methods were adopted to train evaluate residents skills. 180 trained through for two weeks.Then a test on skills by was conducted after training. 172 questionnaires evaluation effect collected analyzed. Results With regard skill, 96.51％ considered that it helpful work, 98.26％ would make their operation more standandized. Conclusion The is an important way...
Objective To investigate the efficacy and safety of albumin-bound paclitaxel in treatment advanced malignant tumors. Methods Patients stage cancer who had drug-resistant relapse after receiving multiple-line received chemotherapy with from May 2016 to April 2018 Daxing Hospital Capital Medical University. Their clinical data were collected evaluate profile. Results 36 patients treatment-resistent tumors evaluable enrolled. Of 36 patients, 55.56% (20) previously paclitaxel. The...