A5101588715- Computational Drug Discovery Methods
- Lung Cancer Treatments and Mutations
- Renal Diseases and Glomerulopathies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Retinoids in leukemia and cellular processes
- Cell death mechanisms and regulation
- interferon and immune responses
- Radiomics and Machine Learning in Medical Imaging
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- Immune cells in cancer
- CNS Lymphoma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Vascular Tumors and Angiosarcomas
- Optical Coherence Tomography Applications
- Digital Imaging for Blood Diseases
- Soft tissue tumors and treatment
- Advanced Technologies in Various Fields
Guangdong Ocean University
2024
Xinyang College of Agriculture and Forestry
2023
First Affiliated Hospital of Wenzhou Medical University
2015-2023
Wenzhou Medical University
2015-2023
NGM Biopharmaceuticals (United States)
2017-2021
Third Affiliated Hospital of Sun Yat-sen University
2020
Sun Yat-sen University
2020
University of California, San Francisco
2017
Fox Chase Cancer Center
2013
Philadelphia University
2013
Significance The interferons are small secreted proteins with powerful antiviral and cytotoxic properties. Here, we outline a signaling pathway activated by that results in the precipitous necrotic death of susceptible cells. Interferon-induced necrosis proceeds via novel, progressive mechanism requires RNA transcription, as well sequential activity three serine-threonine kinases: PKR, RIP1, RIP3. This pronecrotic kinase cascade is normally held check FADD caspases. As can be disabled...
Abstract Suppressive myeloid cells inhibit antitumor immunity by preventing T-cell responses. Immunoglobulin-like transcript 3 (ILT3; also known as LILRB4) is highly expressed on tumor-associated and promotes their suppressive phenotype. However, the ligand that engages ILT3 within tumor microenvironment renders unknown. Using a screening approach, we identified fibronectin functional for ILT3. The interaction of with polarized toward state, these effects were reversed an ILT3-specific...
Advanced renal cell carcinoma (RCC) is an invariably fatal cancer. Currently, small-molecule inhibitors that target growth, angiogenesis, or nutrient-sensing pathways represent the primary pharmacologic interventions for this disease, but these only delay tumor progression and are not curative. The cytokine IFN-γ showed potential to provide lasting remission in several phase I/II trials advanced RCCs, subsequent trials, including a multicenter III study using as monotherapy were less...
Metastatic renal cell carcinoma (RCC) is an incurable disease in clear need of new therapeutic interventions. In early-phase clinical trials, the cytokine IFN-γ showed promise as a biotherapeutic for advanced RCC, but subsequent trials were less promising. These however, focused on indirect immunomodulatory properties IFN-γ, and its direct anti-tumor effects, including ability to kill tumor cells, remains mostly unexploited. We have previously shown that induces RIP1 kinase-dependent...
Advanced renal cancer is an incurable malignancy in need of novel therapeutic avenues. We have generated interferon γ (IFNγ)-based fusion antibodies (immunocytokines) that target CD70, a putative biomarker cancer. These immunocytokines efficiently labeled cells, and, when combined with the proteasome inhibitor bortezomib, killed them by activating RIP1-dependent necrotic pathway.
The parotid gland is an extremely rare site for extrapulmonary tuberculosis, even in countries where the disease widespread. Clinically, tuberculosis of indistinguishable from other tumors because it frequently presents as a neoplasm. Most patients undergo parotidectomy and tissue diagnosis changes clinical impression. We report 81-year-old man who had 3 × cm infra-auricular mass half year. Pathology demonstrated Warthin's tumor granulomatous stroma. Acid-fast stain was positive. Pulmonary...
Abstract Background and purpose The mechanism of glomerular microthrombosis (GMT) in patients with lupus nephritis (LN) is largely unknown. aim this study to investigate the association between antiphospholipid antibodies (aPLs) factor Bb LN GMT. Methods Patients biopsy‐proven hospitalized from July 2015 2018 our hospital were selected for study. Levels anticoagulant (LAC), anticardiolipin (aCLs), anti‐β2‐glycoprotein I (anti‐β2‐GPI) measured, other clinical pathological data also obtained...
AiWalker is a newly developed robot-assisted gait training system, which features over-ground walking paradigm and somatosensory stimulation during compared to commonly-used devices (e.g. Lokomat). However, no study has examined its true therapeutic effect possible mechanism or mediating factor(s).To investigate 1) the of on balance ability in patients with stroke, 2) whether improvement function represents one factors for such effect.Three impaired due stroke were recruited. Two received...
<title>Abstract</title> Recent research has demonstrated that various network architectures combined with Transformers exhibit outstanding performance, particularly in models integrating CNNs, which have made significant strides the field of fault diagnosis. However, existing combine and CNNs fail to effectively utilise multi-scale convolutions for feature extraction suffer from channel weight information loss, weakens network's capability. Therefore, this paper proposes an MK-ACFormer...
Metastatic cancer to the palatine tonsil is extremely rare. We describe a 66-year-old man who was diagnosed with hepatocellular carcinoma 2 years previously and had sensation of having lump in his throat for 1 month before presentation. One reddish-blue, ulcerated, granular tumor found at right tonsillar fossa. After tonsillectomy, pathology showed metastatic carcinoma. The patient died from sepsis hepatic failure 9 months later.
To investigate the effects of robot-assisted (RA) virtual reality (VR) intervention on motor function (MF) and nerve (NF) in patients with cerebral stroke (CS), 60 apoplexy hemiplegia convalescence stage were randomly divided into conventional group (CG) experimental (EG) (30 each group). The CG received routine rehabilitation training (RT), EG used robot VR technology for RT. Brunnstrom classification Fugl-meyer score to evaluate upper limb (UL) function. Maslach Burnout Inventory (MBI)...