NFDI4DS | UHH-SEMS - Publication Details

Kyle O'Hollaren

ORCID: 0009-0002-8217-7653

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A5091352850

Research Areas

Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Chronic Myeloid Leukemia Treatments
Macrophage Migration Inhibitory Factor
Immune Cell Function and Interaction
Cell Adhesion Molecules Research
Retinoids in leukemia and cellular processes
Structural Behavior of Reinforced Concrete
Immune cells in cancer
Galectins and Cancer Biology
Acute Myeloid Leukemia Research
Cytokine Signaling Pathways and Interactions
Cancer Immunotherapy and Biomarkers

NGM Biopharmaceuticals (United States)
2021-2024

The Fibronectin–ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells

OPENALEX - Publications

Kevin J. Paavola Julie M. Roda Vicky Y. Lin Peirong Chen Kyle O'Hollaren and 29 more

Abstract Suppressive myeloid cells inhibit antitumor immunity by preventing T-cell responses. Immunoglobulin-like transcript 3 (ILT3; also known as LILRB4) is highly expressed on tumor-associated and promotes their suppressive phenotype. However, the ligand that engages ILT3 within tumor microenvironment renders unknown. Using a screening approach, we identified fibronectin functional for ILT3. The interaction of with polarized toward state, these effects were reversed an ILT3-specific...

10.1158/2326-6066.cir-21-0240 article EN cc-by-nc-nd Cancer Immunology Research 2021-08-23

ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Solid tumors are dense three-dimensional (3D) multicellular structures that enable efficient receptor-ligand trans interactions via close cell-cell contact. Immunoglobulin-like transcript (ILT)2 and ILT4 related immune-suppressive receptors play a role in the inhibition of myeloid cells within tumor microenvironment. The relative contribution ILT2 to immune context solid tissue has not been fully explored. We present evidence both contribute inhibition. found although inhibits cell...

10.1158/2326-6066.cir-23-0568 article EN Cancer Immunology Research 2024-02-23

Supplementary Methods, Tables, and Figure Legends from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Methods, Tables, and Figure Legends</p>

10.1158/2326-6066.25736167.v1 preprint EN cc-by 2024-05-02

Figure S5 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S5</p>

10.1158/2326-6066.25736185.v1 preprint EN cc-by 2024-05-02

Figure S8 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S8</p>

10.1158/2326-6066.25736173.v1 preprint EN cc-by 2024-05-02

Supplementary Methods, Tables, and Figure Legends from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Methods, Tables, and Figure Legends</p>

10.1158/2326-6066.25736167 preprint EN cc-by 2024-05-02

Figure S4 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S4</p>

10.1158/2326-6066.25736188.v1 preprint EN cc-by 2024-05-02

Figure S9 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S9</p>

10.1158/2326-6066.25736170 preprint EN cc-by 2024-05-02

Figure S4 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S4</p>

10.1158/2326-6066.25736188 preprint EN cc-by 2024-05-02

Figure S7 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S7</p>

10.1158/2326-6066.25736176.v1 preprint EN cc-by 2024-05-02

Figure S9 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S9</p>

10.1158/2326-6066.25736170.v1 preprint EN cc-by 2024-05-02

Figure S7 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S7</p>

10.1158/2326-6066.25736176 preprint EN cc-by 2024-05-02

Figure S6 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S6</p>

10.1158/2326-6066.25736179 preprint EN cc-by 2024-05-02

Figure S8 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S8</p>

10.1158/2326-6066.25736173 preprint EN cc-by 2024-05-02

Figure S5 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S5</p>

10.1158/2326-6066.25736185 preprint EN cc-by 2024-05-02

Figure S6 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S6</p>

10.1158/2326-6066.25736179.v1 preprint EN cc-by 2024-05-02

Figure S10 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S10</p>

10.1158/2326-6066.25736221.v1 preprint EN cc-by 2024-05-02

Figure S11 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S11</p>

10.1158/2326-6066.25736215 preprint EN cc-by 2024-05-02

Figure S13 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S13</p>

10.1158/2326-6066.25736206.v1 preprint EN cc-by 2024-05-02

Figure S1 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S1</p>

10.1158/2326-6066.25736227.v1 preprint EN cc-by 2024-05-02

Figure S1 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S1</p>

10.1158/2326-6066.25736227 preprint EN cc-by 2024-05-02

Figure S2 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S2</p>

10.1158/2326-6066.25736194.v1 preprint EN cc-by 2024-05-02

Figure S16 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S16</p>

10.1158/2326-6066.25736197.v1 preprint EN cc-by 2024-05-02

Figure S15 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S15</p>

10.1158/2326-6066.25736200.v1 preprint EN cc-by 2024-05-02

Figure S14 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

<p>Supplementary Figure S14</p>

10.1158/2326-6066.25736203 preprint EN 2024-05-02

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