Kikuye Koyano
A5093990193- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chronic Myeloid Leukemia Treatments
- Macrophage Migration Inhibitory Factor
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Structural Behavior of Reinforced Concrete
- Immune cells in cancer
- Melanoma and MAPK Pathways
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Disorders and Functions
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Pregnancy and preeclampsia studies
- Oral microbiology and periodontitis research
- Veterinary medicine and infectious diseases
- Immunotherapy and Immune Responses
- Streptococcal Infections and Treatments
NGM Biopharmaceuticals (United States)
2024
University of California, Los Angeles
2017-2020
We recently reported that resistance to PD-1 blockade in a refractory lung cancer-derived model involved increased collagen deposition and the collagen-binding inhibitory receptor leukocyte-associated immunoglobulin-like 1 (LAIR1). Thus, we hypothesized LAIR1 cooperated suppress therapeutic response. In this study, report is associated with tumor stroma highly expressed by intratumoral myeloid cells both human tumors mouse models of cancer. Stroma-associated exhibit suppressive phenotype...
It was recently discovered that abundant and stable extracellular RNA (exRNA) species exist in bodily fluids. Saliva is an emerging biofluid for biomarker development noninvasive detection screening of local systemic diseases. Use RNA-Sequencing (RNA-Seq) to profile exRNA rapidly growing; however, no single preparation analysis protocol can be used all biofluids. Specifically, RNA-Seq saliva particularly challenging owing high abundance bacterial contents low salivary exRNA. Given the...
Abstract Motivation Analysis of RNA sequencing (RNA-Seq) data in human saliva is challenging. Lack standardization and unification the bioinformatic procedures undermines saliva‘s diagnostic potential. Thus, it motivated us to perform this study. Results We applied principal pipelines for analysis small RNA-Seq 98 healthy Korean volunteers including either direct or indirect mapping reads genome using Bowtie1. alignments exogenous genomes by another pipeline revealed that almost all map...
Coevolution of the human host and its associated microbiota has led to sophisticated interactions maintain a delicate homeostasis. Emerging evidence suggests that in addition small molecules, peptides, proteins, regulatory noncoding RNAs (sRNAs) might play an important role cross-domain interactions. In this study, we revealed presence diverse transfer RNA–derived (tsRNAs) among salivary sRNAs. We selected 2 tsRNAs (tsRNA-000794 tsRNA-020498) for further study based on their high sequence...
Solid tumors are dense three-dimensional (3D) multicellular structures that enable efficient receptor-ligand trans interactions via close cell-cell contact. Immunoglobulin-like transcript (ILT)2 and ILT4 related immune-suppressive receptors play a role in the inhibition of myeloid cells within tumor microenvironment. The relative contribution ILT2 to immune context solid tissue has not been fully explored. We present evidence both contribute inhibition. found although inhibits cell...
Alcohol (ethanol, EtOH) consumption during pregnancy can result in fetal alcohol spectrum disorders (FASDs), which are characterized by prenatal and postnatal growth restriction craniofacial dysmorphology. Recently, cell-derived extracellular vesicles, including exosomes microvesicles containing several species of RNAs (exRNAs), have emerged as a mechanism cell-to-cell communication. However, EtOH’s effects on the biogenesis function non-coding exRNAs development not been explored....
microRNAs (miRNAs) are small non-coding RNAs that play critical roles in gene regulation. The presence of miRNAs extracellular biofluids is increasingly recognized. However, most previous characterization focused on their overall expression levels. Alternative sequence isoforms and modifications were rarely considered the space. Here, we developed a highly accurate bioinformatic method, called miNTA, to identify 3' non-templated additions (NTAs) using RNA-sequencing data. Using conducted an...
<p>Supplementary Methods, Tables, and Figure Legends</p>
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<p>Supplementary Methods, Tables, and Figure Legends</p>
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<p>Supplementary Figure S5</p>
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<p>Supplementary Figure S1</p>