Nandini Pal Basak
A5010299438- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chronic Myeloid Leukemia Treatments
- Cancer Immunotherapy and Biomarkers
- Macrophage Migration Inhibitory Factor
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Structural Behavior of Reinforced Concrete
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Acute Myeloid Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Kruppel-like factors research
- Colorectal Cancer Treatments and Studies
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Cell Image Analysis Techniques
- Advanced Proteomics Techniques and Applications
- Ovarian cancer diagnosis and treatment
Anthem Biosciences (India)
2020-2025
Mitra Biotech (India)
2019
Institute for Stem Cell Biology and Regenerative Medicine
2016
Saha Institute of Nuclear Physics
2012-2015
University of Minnesota
2005
Recently, migration and invasion of breast cancer cells have been linked with dysregulated mitochondrial dynamics. Mitochondria are essential cellular organelles that undergo continuous dynamic cycles fission fusion. It has proposed a delicate balance between these two processes is important for many pathophysiological outcomes including cancer. Epstein-Barr virus (EBV) gamma herpesvirus associated various lymphoid epithelial malignancies. The viral latent membrane protein 2A (LMP2A) shown...
Abstract On-treatment biomarkers for assessing the response to immune-oncology (I/O) therapy have a better predictive value than baseline markers, prior treatment1. The Farcast TruTumor histoculture platform that preserves near native tumor microenvironment has potential identify such post treatment with I/O therapy2. Accessing fresh sample is often challenging, limiting clinical utility of ex-vivo platforms. To address this limitation, we assessed exosomes from explant culture supernatants...
Notch pathway is a well-known factor in the development of lymphoid lineage. However, its role myeloid lineage has remained ambiguous. We looked into effect Notch1 on megakaryocytic commitment and found an increase megakaryocyte-specific markers upon transfection with intracellular domain (NICD). This was mediated by Akt whereby constitutive activation increased megakaryocyte markers, whereas inhibition signalling reduced these marker levels. Along change differentiation status, NICD-induced...
Abstract Dynamic interactions within the tumor micro-environment drive patient response to immune checkpoint inhibitors. Existing preclinical models lack true representation of this complexity. Using a Head and Neck cancer derived TruTumor histoculture platform, spectrum 70 patients anti-PD1 treatment is investigated in study. With subset 55 samples, multiple assays characterize T-cell reinvigoration cytotoxicity are performed. Based on levels these two parameters, stratified into five...
Solid tumors are dense three-dimensional (3D) multicellular structures that enable efficient receptor-ligand trans interactions via close cell-cell contact. Immunoglobulin-like transcript (ILT)2 and ILT4 related immune-suppressive receptors play a role in the inhibition of myeloid cells within tumor microenvironment. The relative contribution ILT2 to immune context solid tissue has not been fully explored. We present evidence both contribute inhibition. found although inhibits cell...
Abstract Presence of CD4+CD8+ Double Positive T (DPT) cells in the tumor microenvironment has been correlated with good prognosis1. Renal cell carcinoma (RCC) is reported to have relatively much higher DPT sub-populations as compared other cancer types1,2. RCC were express high programmed death protein-1(PD-1) and therefore considered a potential target for checkpoint based immunotherapy2. However, clinical relevance these determining response anti-PD-1 not yet studied. Using near native...
<p>Supplementary Methods, Tables, and Figure Legends</p>
<p>Supplementary Figure S5</p>
<p>Supplementary Figure S8</p>
<p>Supplementary Methods, Tables, and Figure Legends</p>
<p>Supplementary Figure S4</p>
<p>Supplementary Figure S9</p>
<p>Supplementary Figure S4</p>
<p>Supplementary Figure S7</p>
<p>Supplementary Figure S9</p>
<p>Supplementary Figure S7</p>
<p>Supplementary Figure S6</p>
<p>Supplementary Figure S8</p>
<p>Supplementary Figure S5</p>
<p>Supplementary Figure S6</p>
<p>Supplementary Figure S10</p>
<p>Supplementary Figure S11</p>