NFDI4DS | UHH-SEMS - Publication Details

Kevin J. Paavola

ORCID: 0009-0009-4884-9103

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A5075542172

Research Areas

Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Chronic Myeloid Leukemia Treatments
Macrophage Migration Inhibitory Factor
Immune Cell Function and Interaction
Immune cells in cancer
Structural Behavior of Reinforced Concrete
Retinoids in leukemia and cellular processes
Cell Adhesion Molecules Research
Receptor Mechanisms and Signaling
Neuropeptides and Animal Physiology
Galectins and Cancer Biology
Acute Myeloid Leukemia Research
Cancer Immunotherapy and Biomarkers
Protein Kinase Regulation and GTPase Signaling
RNA Interference and Gene Delivery
Neurogenetic and Muscular Disorders Research
Diabetes Treatment and Management
Ion channel regulation and function
Nuclear Receptors and Signaling
Axon Guidance and Neuronal Signaling
Cytokine Signaling Pathways and Interactions
Apelin-related biomedical research
S100 Proteins and Annexins
Neonatal Respiratory Health Research
Neuroscience and Neuropharmacology Research

NGM Biopharmaceuticals (United States)
2016-2024

Stanford University
2014-2015

Emory University
2010-2013

Type IV collagen is an activating ligand for the adhesion G protein–coupled receptor GPR126

OPENALEX - Publications

Kevin J. Paavola Harwin Sidik J. Bradley Zuchero Michael R. Eckart William S. Talbot

Type IV collagen activates the cell surface receptor GPR126, an orphan that is crucial for Schwann differentiation and myelination.

10.1126/scisignal.2005347 article EN Science Signaling 2014-08-12

The N Terminus of the Adhesion G Protein-coupled Receptor GPR56 Controls Receptor Signaling Activity

OPENALEX - Publications

Kevin J. Paavola Jason R. Stephenson Stefanie L. Ritter Shawn Alter Randy A. Hall

10.1074/jbc.m111.247973 article EN cc-by Journal of Biological Chemistry 2011-06-28

Mutations of GPR126 Are Responsible for Severe Arthrogryposis Multiplex Congenita

OPENALEX - Publications

Gianina Ravenscroft Flora Nolent Sulekha Rajagopalan Ana M. Meireles Kevin J. Paavola and 16 more

10.1016/j.ajhg.2015.04.014 article EN publisher-specific-oa The American Journal of Human Genetics 2015-05-21

Brain-specific Angiogenesis Inhibitor-1 Signaling, Regulation, and Enrichment in the Postsynaptic Density

OPENALEX - Publications

Jason R. Stephenson Kevin J. Paavola Stacy A. Schaefer Balveen Kaur Erwin G. Van Meir and 1 more

10.1074/jbc.m113.489757 article EN cc-by Journal of Biological Chemistry 2013-06-20

The Fibronectin–ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells

OPENALEX - Publications

Kevin J. Paavola Julie M. Roda Vicky Y. Lin Peirong Chen Kyle O'Hollaren and 29 more

Abstract Suppressive myeloid cells inhibit antitumor immunity by preventing T-cell responses. Immunoglobulin-like transcript 3 (ILT3; also known as LILRB4) is highly expressed on tumor-associated and promotes their suppressive phenotype. However, the ligand that engages ILT3 within tumor microenvironment renders unknown. Using a screening approach, we identified fibronectin functional for ILT3. The interaction of with polarized toward state, these effects were reversed an ILT3-specific...

10.1158/2326-6066.cir-21-0240 article EN cc-by-nc-nd Cancer Immunology Research 2021-08-23

DEVELOPMENT OF BRB-002, A NOVEL NEXT-GENERATION ANTI-CD47 MOLECULE, FOR ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

OPENALEX - Publications

B. Alexander Yi Pierre Signore Kevin J. Paavola Ann M. Marseilles Sharline Chen and 9 more

10.1016/s0735-1097(25)00801-0 article EN Journal of the American College of Cardiology 2025-03-29

Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling

OPENALEX - Publications

Hadas Galon-Tilleman Hong Yang Maria A. Bednarek Sandra M. Spurlock Kevin J. Paavola and 9 more

10.1074/jbc.m116.748103 article EN cc-by Journal of Biological Chemistry 2016-12-23

CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway

OPENALEX - Publications

Susan D. Reynolds Paul R. Reynolds Joshua C. Snyder Fadra Whyte Kevin J. Paavola and 1 more

Pulmonary host defense employs a combination of biochemical and biophysical activities to recognize, inactivate, mediate clearance environmental agents as well modulate the overall response such challenge. Dysregulation inflammatory arm this is associated with chronic lung diseases (CLD) including cystic fibrosis obstructive disease. Although mechanisms mediating immunoregulation are incompletely characterized, decrements in levels nonciliated secretory cell product Clara protein (CCSP)...

10.1152/ajplung.00014.2007 article EN AJP Lung Cellular and Molecular Physiology 2007-03-24

ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Solid tumors are dense three-dimensional (3D) multicellular structures that enable efficient receptor-ligand trans interactions via close cell-cell contact. Immunoglobulin-like transcript (ILT)2 and ILT4 related immune-suppressive receptors play a role in the inhibition of myeloid cells within tumor microenvironment. The relative contribution ILT2 to immune context solid tissue has not been fully explored. We present evidence both contribute inhibition. found although inhibits cell...

10.1158/2326-6066.cir-23-0568 article EN Cancer Immunology Research 2024-02-23

GLAST stability and activity are enhanced by interaction with the PDZ scaffold NHERF-2

OPENALEX - Publications

Stefanie L. Ritter Matthew J. Asay Maryse Paquet Kevin J. Paavola Rachel E. Reiff and 2 more

10.1016/j.neulet.2010.04.043 article EN Neuroscience Letters 2010-04-28

Supplementary Methods, Tables, and Figure Legends from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Supplementary Methods, Tables, and Figure Legends

10.1158/2326-6066.25736167.v1 preprint EN cc-by 2024-05-02

Figure S5 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Supplementary Figure S5

10.1158/2326-6066.25736185.v1 preprint EN cc-by 2024-05-02

Figure S8 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Supplementary Figure S8

10.1158/2326-6066.25736173.v1 preprint EN cc-by 2024-05-02

Supplementary Methods, Tables, and Figure Legends from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Supplementary Methods, Tables, and Figure Legends

10.1158/2326-6066.25736167 preprint EN cc-by 2024-05-02

Figure S4 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Supplementary Figure S4

10.1158/2326-6066.25736188.v1 preprint EN cc-by 2024-05-02

Figure S9 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Supplementary Figure S9

10.1158/2326-6066.25736170 preprint EN cc-by 2024-05-02

Figure S4 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Supplementary Figure S4

10.1158/2326-6066.25736188 preprint EN cc-by 2024-05-02

Figure S7 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Supplementary Figure S7

10.1158/2326-6066.25736176.v1 preprint EN cc-by 2024-05-02

Figure S9 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Supplementary Figure S9

10.1158/2326-6066.25736170.v1 preprint EN cc-by 2024-05-02

Figure S7 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Supplementary Figure S7

10.1158/2326-6066.25736176 preprint EN cc-by 2024-05-02

Figure S6 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Supplementary Figure S6

10.1158/2326-6066.25736179 preprint EN cc-by 2024-05-02

Figure S8 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Supplementary Figure S8

10.1158/2326-6066.25736173 preprint EN cc-by 2024-05-02

Figure S5 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Supplementary Figure S5

10.1158/2326-6066.25736185 preprint EN cc-by 2024-05-02

Figure S6 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms

OPENALEX - Publications

Jane Tian Amir M. Ashique Sabrina Weeks Tian Lan Hong Yang and 43 more

Supplementary Figure S6

10.1158/2326-6066.25736179.v1 preprint EN cc-by 2024-05-02

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