A5089277303- Liver Disease Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Fibroblast Growth Factor Research
- Drug Transport and Resistance Mechanisms
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Inflammatory Biomarkers in Disease Prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Diseases and Immunity
- Acute Kidney Injury Research
- Edible Oils Quality and Analysis
- Kruppel-like factors research
- Complement system in diseases
- Circular RNAs in diseases
- Peroxisome Proliferator-Activated Receptors
- MicroRNA in disease regulation
- Gut microbiota and health
- Pediatric Hepatobiliary Diseases and Treatments
- Liver physiology and pathology
- Diet, Metabolism, and Disease
- Renal and related cancers
- Renin-Angiotensin System Studies
- Angiogenesis and VEGF in Cancer
- Metabolism, Diabetes, and Cancer
University of Bari Aldo Moro
2016-2025
Istituto Nazionale Biostrutture e Biosistemi
2018-2025
Sapienza University of Rome
2018
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2015
Istituto Tumori Bari
2013-2015
Mario Negri Sud Foundation
2013
University of Turin
2012
Pharming Group (Netherlands)
2012
BackgroundIncreasing evidence demonstrates a phenotypic plasticity of endothelial cells (ECs). Endothelial-to-mesenchymal transition (EndMT) contributes to the development tissue fibrosis. However, pathogenic factors and signalling pathways regulating this process in ischaemia/reperfusion (I/R) injury are still poorly understood.
BackgroundDisruption of bile acid (BA) homeostasis plays a key role in intestinal inflammation. The gut-liver axis is the main site for regulation BA synthesis and pool size via combined action nuclear Farnesoid X Receptor (FXR) enterokine Fibroblast Growth Factor 19 (FGF19). Increasing evidence have linked derangement metabolism with dysbiosis mucosal Thus, here we aimed to investigate potential an FGF19 analogue on microbiota inflammation.MethodsA novel engineered non-tumorigenic variant...
BackgroundEpicardial adipose tissue (EAT) is an atypical fat depot surrounding the heart with a putative role in development of atherosclerosis.
Inflammatory bowel disease (IBD) is a multifactorial intestinal disorder characterized by chronic inflammation. The etiology of IBD still unclear, although genetic, environmental and host factors have been associated to the disease. Extra-virgin olive oil (EVO) central component Mediterranean diet it decreases inflammation interfering with arachidonic acid NF-κB signaling pathways. Specifically, different components EVO are able confer advantages in terms health their site action. For...
Abstract Visceral obesity is characterized by a low-grade inflammatory systemic state that contributes to the genesis of non-alcoholic fatty liver disease (NAFLD), frequently associated with fibrosis. Non-invasive serum markers have recently emerged as reliable, easy-to-use scores predict NAFLD often linked metabolic and cardiovascular risk. Thus, in this cross-sectional study, we investigated population 1225 subjects if AST Platelet Ratio Index (APRI), one non-invasive fibrosis markers, can...
Background Tryptase is a serin protease stored and released from mast cells (MCs) that plays role in tumour angiogenesis. In this study we aimed to evaluate serum tryptase levels colo-rectal cancer (CRC) patients before (STLBS) after (STLAS) radical surgical resection. We also evaluated cell density positive (MCDPT) microvascular (MVD) primary tissue. Methods A series of 61 with stage B C CRC (according the Astler Coller staging system) were selected. Serum blood samples collected one day...
Abstract The Atherogenic Index of Plasma (AIP), calculated by log (Triglycerides/HDL-C), has been proposed as a marker atherogenic and cardiovascular risk. Atherosclerosis Metabolic Dysfunction—Associated Steatotic Liver Disease (MASLD) share some pathogenic features may be considered clinical manifestations Syndrome. In this study, we aimed to investigate the role increased AIP putative metabolic biomarker for MASLD. 1,496 individuals (49% males 51% females) underwent examination Syndrome...
Malignancies are one of the main causes mortality in diabetic patients; however, to date, very limited data have been reported on specific influence type 2 diabetes mellitus (T2DM) survival patients with renal cell carcinoma (RCC). In present long-term retrospective study, we investigated whether T2DM may overall (OS), cancer-specific (CSS), and progression-free (PFS) surgically treated RCC. Medical records 924 by radical or partial nephrectomy for sporadic, unilateral RCC were reviewed....
Critical regulation of bile acid (BA) pool size and composition occurs via an intensive molecular crosstalk between the liver gut, orchestrated by combined actions nuclear Farnesoid X receptor (FXR) enterokine fibroblast growth factor 19 (FGF19) with final aim reducing hepatic BA synthesis in a negative feedback fashion. Disruption homeostasis increased toxic levels leads to higher incidence hepatocellular carcinoma (HCC). While native FGF19 has anti-cholestatic anti-fibrotic activity liver,...
Abstract Aims Metabolic syndrome (MS) is a cluster of cardio-metabolic risk factors associated with atherosclerosis and low-grade inflammation. Using unbiased expression screenings in peripheral blood mononuclear cells, we depict here novel chart 678 genes 84 microRNAs (miRNAs) controlling inflammatory, immune metabolic responses. In order to further elucidate the link between inflammation HDL cholesterol pathway MS, focussed on regulation ATP-binding cassette transporter A1 (ABCA1), key...
Altered bile acid (BA) signaling is associated with hepatotoxicity. The farnesoid X receptor (FXR) a nuclear that transcriptionally regulates BA homeostasis. Mice FXR ablation present hepatocarcinoma (HCC) due to high toxic levels. Abcb4 accumulate within the ducts and HCC. We have previously shown intestinal specific activation of by transgenic VP16-FXR chimera able reduce pool size prevent Here we tested chemical administering for 15 months dual FXR/ membrane G protein-coupled (TGR5)...
Metabolic Syndrome (MS) is characterized by a low-grade inflammatory state causing an alteration of non-invasive indexes derived from blood count, namely monocyte-to-HDL ratio (MHR), neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR). We analyse population 771 subjects (394 controls and 377 MS patients) to evaluate the best predictive index MS. The diagnosis was made according 2006 criteria International Diabetes Federation (IDF). performed ROC curve...