A5024426681- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Blood Coagulation and Thrombosis Mechanisms
- Complement system in diseases
- Organ Donation and Transplantation
- Renal and related cancers
- Renal and Vascular Pathologies
- Cytomegalovirus and herpesvirus research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Genetic and Kidney Cyst Diseases
- Parathyroid Disorders and Treatments
- Biomarkers in Disease Mechanisms
- Systemic Lupus Erythematosus Research
- Neurological Complications and Syndromes
- Erythropoietin and Anemia Treatment
- Platelet Disorders and Treatments
- Renal cell carcinoma treatment
- Vasculitis and related conditions
- Viral-associated cancers and disorders
- Pregnancy and Medication Impact
- T-cell and B-cell Immunology
Agostino Gemelli University Polyclinic
2019-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2025
Università Cattolica del Sacro Cuore
2019-2025
University of Oxford
2023
University of Bari Aldo Moro
2006-2022
Azienda USL di Bologna
2021
Sheffield Teaching Hospitals NHS Foundation Trust
2021
University College London
2021
University of Foggia
2011-2020
RELX Group (United States)
2019
Recipients of organ transplants are susceptible to Kaposi's sarcoma as a result treatment with immunosuppressive drugs. Sirolimus (rapamycin), an drug, may also have antitumor effects.
Abstract Background Chronic renal disease (CKD) is characterized by complex changes in cell metabolism leading to an increased production of oxygen radicals, that, turn has been suggested play a key role numerous clinical complications this pathological condition. Several reports have focused on the identification biological elements involved development systemic biochemical alterations CKD, but abundant literature results fragmented and not exhaustive. Results To better define cellular...
Background: Acute kidney injury (AKI), even if followed by renal recovery, is a risk factor for the future development of chronic disease (CKD) and end-stage (ESRD). In previous years, novel insights in pathophysiology CKD progression suggested causal link between AKI due to maladaptive repair after severe repeated injury. Summary: Several pathological mechanisms have been proposed contribute transition CKD/ESRD including hypoxia microvascular rarefaction, alterations resident cell...
BackgroundIncreasing evidence demonstrates a phenotypic plasticity of endothelial cells (ECs). Endothelial-to-mesenchymal transition (EndMT) contributes to the development tissue fibrosis. However, pathogenic factors and signalling pathways regulating this process in ischaemia/reperfusion (I/R) injury are still poorly understood.
Tubulointerstitial damage is a common histopathological feature of acute and chronic renal diseases prognostic indicator function outcome. Monocytes infiltrating the interstitium, through release cytokines and/or growth factors, may play key role in pathogenesis tubulointerstitial damage. Monocyte chemotactic peptide-1 (MCP-1) specific powerful chemoattractant activating factor for monocytes. This study investigated MCP-1 expression its correlation with monocyte infiltration biopsies...
Mononuclear cell infiltration is a common histopathological feature of acute renal transplant rejection, in which it seems to play key role the pathogenesis tubulointerstitial lesions. Monocyte chemotactic peptide-1 (MCP-1) specific and activating factor for monocytes. Thus, present study was aimed at evaluating MCP-1 gene protein expression biopsies kidney recipients with deterioration graft function, correlate extent monocyte infiltration. We studied 20 dysfunction (13 seven tubular...
Sirolimus (SRL) has been shown to improve long-term graft survival in several calcineurin inhibitor avoidance/minimization protocols. Although SRL suggested reduce the progression of chronic renal damage and prevent development neoplasia, two most prominent challenges field transplantation, its use is significantly limited by an extremely high incidence side effects. Some effects are directly linked antiproliferative action SRL, whereas mechanisms underlying undesired drug still far from...
Chronic allograft nephropathy (CAN) represents the main cause of renal loss after 1 yr transplantation. Calcineurin inhibitor (CNI) use is associated with increased graft expression profibrotic cytokines, whereas rapamycin inhibits fibroblast proliferation. The aim this randomized, prospective, open-label, single-center study was to evaluate histologic and clinical effect on biopsy-proven CAN. Eighty-four consecutive patients who had CAN received a transplant were randomized receive either...
In the past few years, adult renal progenitor/stem cells (ARPCs) have been identified in human kidneys, and particularly Bowman's capsule proximal tubules. They may play an important role kidney regenerative processes might prospectively be ideal cell type for treatment of both acute chronic injury. this study, microarray analysis 6 gene clusters that discriminated normal glomerular tubular ARPCs from epithelial mesenchymal stem cells. The top-scored pathway ARPC expression profile contained...
Klotho is an anti-aging factor mainly produced by renal tubular epithelial cells (TEC) with pleiotropic functions. down-regulated in acute kidney injury native kidney; however, the modulation of transplantation has not been investigated. In a swine model ischemia/reperfusion (IRI), we observed remarkable reduction 24 h from IRI. Complement inhibition C1-inhibitor preserved expression vivo abrogating nuclear kappa B (NF-kB) signaling. accordance, complement anaphylotoxin C5a led to...
A delay in the diagnosis and treatment of iatrogenic obstructive ureteral injury is most important prognostic factor for worse results terms lesion repair renal function recovery. The role time relief determining onset failure arterial hypertension patients with was evaluated. In addition, we analyzed value ratio urinary epidermal growth factor-to-monocyte chemotactic peptide-1 predicting long-term deterioration.A total 76 treated reconstructive procedures were prospectively enrolled study....
Abstract Pentraxin-3 (PTX3) is a member of the pentraxin family innate immune regulators, which includes C-reactive protein (CRP). PTX3 has been implicated in angiogenesis, proliferation, and escape cancer. In present study, we evaluated tissue expression serum concentration as biomarker to discriminate prostatic inflammation benign hyperplasia (BPH) from prostate cancer, determine whether status may predict progression BPH We analyzed 40 patients with biopsy-proven who underwent second...
Epigenetic mechanisms, such as DNA methylation, affect tubular maladaptive response after Acute Kidney Injury (AKI) and accelerate renal aging.Upon ischemia/reperfusion (I/R) injury, Complement activation leads to C5a release that mediates damage; however, little is known about the effect of C5a-C5a Receptor (C5aR) interaction in Renal Tubular Epithelial Cells (RTEC).Through a whole-genome methylation analysis cultured RTEC, we found induced aberrant particularly regions involved cell cycle...
Italy was the first Western country to face COVID-19 pandemic. Here we report results of a national survey on kidney transplantation activity in February and March 2020, three-round Delphi consensus promoted by four scientific societies: Italian Society Organ Transplantation, Nephrology, Anesthesia Intensive Care, Group Antimicrobial Stewardship. All 41 transplant centers were invited express their opinion rounds along with group seven experts. The revealed that, starting from there decline...