A5041761706- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer, Lipids, and Metabolism
- Diet, Metabolism, and Disease
- Peroxisome Proliferator-Activated Receptors
- Gallbladder and Bile Duct Disorders
- Diet and metabolism studies
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Pancreatitis Pathology and Treatment
- Liver Diseases and Immunity
- Lipid Membrane Structure and Behavior
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Trace Elements in Health
- Sphingolipid Metabolism and Signaling
- Digestive system and related health
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Pancreatic and Hepatic Oncology Research
- Inflammatory Bowel Disease
- Kruppel-like factors research
- Lipid metabolism and biosynthesis
University of Bari Aldo Moro
2016-2025
Istituto Nazionale Biostrutture e Biosistemi
2017-2025
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
2022-2023
ORCID
2022
Istituto Tumori Bari
2012-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2021
Azienda Ospedaliera S.Giuseppe Moscati
2016
Mario Negri Sud Foundation
2006-2015
Oncology Group of Southern Italy
2014
Italian Society of Physiotherapy
2014
We explored the effects of bile acids on triglyceride (TG) homeostasis using a combination molecular, cellular, and animal models. Cholic acid (CA) prevents hepatic TG accumulation, VLDL secretion, elevated serum in mouse models hypertriglyceridemia. At molecular level, CA decreases expression SREBP-1c its lipogenic target genes. Through use mutants for short heterodimer partner (SHP) liver X receptor (LXR) α β, we demonstrate critical dependence reduction by either natural or synthetic...
Obstruction of bile flow results in bacterial proliferation and mucosal injury the small intestine that can lead to translocation bacteria across epithelial barrier systemic infection. These adverse effects biliary obstruction be inhibited by administration acids. Here we show farnesoid X receptor (FXR), a nuclear for acids, induces genes involved enteroprotection inhibits overgrowth ileum caused duct ligation. Mice lacking FXR have increased ileal levels compromised barrier. findings reveal...
<h3>Background & aims</h3> Inflammatory bowel disease (IBD) is characterised by chronic intestinal inflammation, resulting from dysregulation of the mucosal immune system and compromised epithelial barrier function. The bile salt, nuclear farnesoid X receptor (FXR), was recently implicated in antibacterial defence aim this study to investigate therapeutic potential FXR agonists treatment inflammation complementary vivo vitro models. <h3>Methods</h3> Colitis induced wild-type (WT)...
In mammals, many aspects of behavior and physiology, in particular cellular metabolism, are coordinated by the circadian timing system. Molecular clocks thought to rely on negative feedback loops clock gene expression that engender oscillations accumulation transcriptional regulatory proteins, such as orphan receptor REV-ERBα. Circadian transcription factors then drive daily rhythms clock-controlled output genes, for example genes encoding enzymes regulators metabolism. To gain insight into...
Gut microbiota influences host health status by providing trophic, protective, and metabolic functions, including bile acid (BA) biotransformation. Microbial imprinting on BA signature modifies pool size hydrophobicity, thus contributing to enterohepatic circulation. Microbiota-targeted therapies are now emerging as effective strategies for preventing and/or treating gut-related diseases. Here, we show that gut modulation induced VSL#3 probiotics enhances deconjugation fecal excretion in...
Dietary lipids can affect metabolic health through gut microbiota-mediated mechanisms, but the influence of lipid-microbiota interaction on liver steatosis is largely unknown. We investigate impact dietary human microbiota composition and effects microbiota-lipid interactions in male mice. In humans, low intake saturated fatty acids (SFA) associated with increased microbial diversity independent fiber intake. mice, poorly absorbed long-chain SFA, particularly stearic acid, induce a shift...
The major pathway for elimination of cholesterol in mammals is via secretion into bile. Biliary mediated by the ATP-binding cassette (ABC) transporters ABCG5 (G5) and ABCG8 (G8) stimulated non-cholesterol steroids cholate diosgenin. To define relationship between G5G8 expression biliary secretion, we measured G5 G8 mRNA levels concentrations genetically manipulated mice expressing 0, 1, 2, 5, 10, or 16 copies two genes. varied directly with copy number hepatic over a >16-fold range. Thus...
Abstract Bile acids have been considered intestinal tumor promoters, and because they are natural ligands for the nuclear receptor FXR, we examined role of FXR in tumorigenesis. Using gain- loss-of-function studies, found that suppresses tumorigenesis vivo. Loss ApcMin/+ chronic colitis mouse models resulted early mortality increased progression via promotion Wnt signaling by infiltrating neutrophils macrophages necrosis factor α production. Treatment with bile acid binding resin...
Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α) is a transcriptional able to up-regulate mitochondrial biogenesis, respiratory capacity, oxidative phosphorylation, and fatty acid β-oxidation with the final aim of providing more efficient pathway for aerobic energy production. In continuously renewed intestinal epithelium, proliferative cells in crypts migrate along villus axis differentiate into mature enterocytes, increasing their capacity finally undergoing apoptosis....
Background: The pericardial adipose tissue (AT) contains a high density of lymphoid clusters. It is unknown whether these clusters play role in post–myocardial infarction (MI) inflammatory responses and cardiac outcome. Methods: Lymphoid were examined epicardial AT humans with or without coronary artery disease. Murine visualized mice subjected to ligation. To study the relevance during after MI, we surgically removed performed B-cell depletion granulocyte-macrophage colony-stimulating...