A5015383378- High Altitude and Hypoxia
- Alcohol Consumption and Health Effects
- Substance Abuse Treatment and Outcomes
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Health, Environment, Cognitive Aging
- Polyomavirus and related diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
- Hemoglobinopathies and Related Disorders
- Homelessness and Social Issues
- Tuberous Sclerosis Complex Research
- Peroxisome Proliferator-Activated Receptors
- Eosinophilic Disorders and Syndromes
- Statistical Methods in Clinical Trials
- Lipid metabolism and disorders
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience of respiration and sleep
- Plant Gene Expression Analysis
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
Tibet University
2006-2024
Peking University
2004
Abstract Background Latexin, also known as endogenous carboxypeptidase inhibitor (CPI), has been found to inhibit mouse stem cell populations and lymphoma proliferation, demonstrating its potential role a tumor suppressor. Our previous study suggested correlation between latexin expression malignant transformation of immortalized human gastric epithelial cells. Here, we examined in carcinomas investigated the effect differential on proliferation cancer cells vitro vivo . Methods Monoclonal...
Hypoxia inducible factors, including HIF1A and HIF2A, play central roles in response to high-altitude hypoxia genetic variants of or HIF2A were associated with sickness adaptation. However, it remains determine whether they are tolerance different levels selection pressure among native Tibetans. We recruited 189 Tibetan subjects living at 2,700 meters (Low level high altitude, LHA), 197 3,200 (Middle altitude MHA), 249 3,700 (High HHA) 269 4,700 (Very VHA) performed association analysis...
High altitude acclimatization is a series of physiological responses taking places when subjects go to altitude. Many factors could influence these processes, such as altitude, ascending speed and individual characteristics. In this study, based on repeated measurement design three sequential measurements at baseline, acute phase chronic phase, we evaluated the effect BMI, smoking drinking number in high by using mixed model partial least square path sample 755 Han Chinese young males. We...
Associations between alcohol use disorders and polymorphisms of genes influencing ethanol metabolism have been widely reported, but gene-gene gene-sex interaction studies rarely examined. Using a set samples collected during an epidemiological study AUDs in Tibetan population China, we performed case-control to investigate the relationship functional AUDs. The sample included 383 individuals with AUDIT score >or=10 350 control subjects <or=5. All participants were genotyped for ALDH2*1/*2,...
Studies of linkage and association in various ethnic populations have revealed many predisposing genes multiple neurotransmitter systems for alcohol use disorders (AUD). However, evidence often is contradictory regarding the contribution most candidate to susceptibility AUD. We, therefore, performed a case-control study investigate possible associations selected from with AUD homogeneous Tibetan community population China. cases (N = 281) an disorder identification test (AUDIT) score ≥10, as...
Repeated extreme environmental training (RET) enhances adaptability and induces lasting methylation modifications. We recruited 64 participants from a high-altitude region (4700 m), including 32 volunteers with repeated exposure, reaching up to 8848 m as many 11 exposures. By analyzing 741,489 CpG loci 39 phenotypes, we identified significant changes in 13 (R
Cirrhosis is a persistent hepatic ailment that emerges from range of causes, including viral infections, alcoholic liver disease, and non-alcoholic fatty disease. It distinguished by the replacement normal parenchyma with fibrous scar tissue, culminating in development insufficiency, portal hypertension, eventual collapse. Several molecular cellular mechanisms contribute to cirrhosis' pathogenesis, activation immune cells dysregulation immune-related pathways. Weighted Gene Co-expression...
Abstract Background: Extreme environmental stress interactions with DNA methylation may produce episodic memory for adaptation. Methods: In the present study, 64 volunteers born and living at an altitude of 4,700 m were recruited, including 32 who repeatedly exposed to high altitudes (up 8,848 m, up 11 times). We explored changes in genes hosting 741,489 CpG loci as well 39 physiological phenotypes under superposition extreme high-altitude exposure (SEH). Results: 13 identified tightly...
Abstract High-altitude polycythemia (HAPC) is a common and serious chronic disease affecting people of highland plains ancestry living at high altitudes. This study investigated genetic susceptibility differences for HAPC among ethnic groups, with 2,248 volunteers participating, including 898 patients (n Han = 450, n Tibetan 448). The included GWAS 198 cases 100, 98), which revealed eight HAPC-susceptibility single-nucleotide polymorphisms four VARIANTs. Among them, the polymorphism locus...