A5101886084- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Phytochemistry and biological activity of medicinal plants
- Medicinal Plant Pharmacodynamics Research
- Ginseng Biological Effects and Applications
- interferon and immune responses
- Cancer Mechanisms and Therapy
- Fibroblast Growth Factor Research
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- Magnolia and Illicium research
- Immune cells in cancer
- Bacterial Genetics and Biotechnology
- Circular RNAs in diseases
- Polyomavirus and related diseases
- Tuberous Sclerosis Complex Research
- Natural Compounds in Disease Treatment
- Circadian rhythm and melatonin
- Lipid metabolism and disorders
- MicroRNA in disease regulation
- Photodynamic Therapy Research Studies
- Eicosanoids and Hypertension Pharmacology
- Influenza Virus Research Studies
- Sphingolipid Metabolism and Signaling
Beijing University of Chinese Medicine
2018-2024
Ministry of Education of the People's Republic of China
2023-2024
Inner Mongolia Medical University
2022
Peking University Cancer Hospital
2011
Peking University
2004-2011
Qiqihar University
2005
Influenza is an acute respiratory infection disease caused by the influenza virus. At present, due to high mutation rate of virus, it difficult for existing antiviral drugs play effective effect continually, so urgent develop a new anti-influenza drug. Recently, more and studies have been conducted on activity Astragalus membranaceus , but specific mechanism this traditional Chinese medicine not clear. In study, results proved that injection showed obvious virus activity. It could improve...
Liver cancer is the second leading cause of cancer‑associated death worldwide. The present study aimed to evaluate infiltration M1‑like tumor‑associated macrophages (TAMs) and explore role TAMs in proliferation apoptosis evasion liver cells. Furthermore, association between TAM efficacy postoperative transcatheter arterial chemoembolization (TACE) for patients with was investigated. levels CD68, human leukocyte antigen‑DR phosphorylated NF‑κB (p‑)p65 were detected by western blot analysis...
Radix Glycyrrhizae (RG)-Radix Euphorbiae Pekinensis (REP) is a representative incompatible herbal pair of Eighteen Incompatible Medicaments (EIM) and has been disputed in clinical application for long time. The present study was performed with the Madin-Darby canine kidney (MDCK) cell line using cytotoxicity assay, apoptosis detection, cycle measurement, reactive oxygen species (ROS) determination, high content analysis (HCA) combination high-performance liquid chromatography (HPLC)...
Background: Malignant melanoma has high morbidity and mortality limited treatment options. Traditional Chinese medicine great potential in the clinical therapy of cancer, theory compatibility is one core content medical theory. Astragalus Membranaceus Radix Trichosanthis are clinically effective for various cancers. Methods: We verified effects AMD, RTD, their "cocktail" on model vitro vivo mechanism its effect Akt-related signaling pathway by network pharmacology, MTT, flow cytometry, LDH,...
Background/Aim. Rhubarb, a traditional Chinese medicine derived from three species, is commonly used in the prescriptions for promoting blood circulation and removing stasis based on its effects of dredging meridians. It has been reported that rhubarb can protect vessels by reducing inflammation inhibiting vascular endothelial injury (VEI), but effective components mechanism VEI are still unclear. This study aimed to compare differences chemical compositions species their inhibitory effect...
Abstract Herpes simplex virus type 1 (HSV-1) plays an important role in the field of gene therapy and viral vaccines, especially as oncolytic virus. However, mass production HSV-1 vectors remains a challenge industry. In this study, microcarrier-mediated serum-reduced medium culture was used to improve bioprocess increase yields. The composition media, which included basal medium, serum concentration, glutamine additive, optimized. process successfully conducted L bioreactor, threefold...
To investigate whether melatonin (MT) secretion in different parts of the gastrointestinal tract (GIT) exhibits seasonal variations and its correlation with immune regulation. Sixty Sprague-Dawley (SD) rats were divided into control model groups, pineal gland was removed group. Stomach, jejunum, ileum, colon tissues obtained during spring equinox, summer solstice, beginning autumn, autumn winter solstice. The levels MT, MT receptors (MR), arylalkylamine N-acetyltransferase (AANAT),...
To maintain the precision and stability of efficacy classical formulas, this study compared origins specifications Bupleuri Radix revealed precise application regularity Bupleurum chinense(Beichaihu) scorzonerifolium(Nanchaihu) in formulas. The indications formulas with as sovereign drug Treatise on Cold Damage Miscellaneous Diseases(Shang Han Za Bing Lun) were investigated. difference well differences chemical composition, liver-protecting lipid-lowering effects decoctions Beichaihu...
Ethnopharmacological relevance: The capitulum of Coreopsis tinctoria Nutt. (Xue-Ju in Chinese) is a precious medicine Xinjiang Uygur Autonomous region China. (In full text refers to the Nutt.) used prevent and treat dyslipidemia, coronary heart disease, etc. Recent studies have shown that its extract has pharmacological effect on hyperlipidemia hyperglycemia.Aim study: study aimed systematically evaluate lipid-lowering activity through mice model HepG2 cell lipid accumulation, investigate...