A5014804385- Advanced Mathematical Modeling in Engineering
- Nonlinear Partial Differential Equations
- Tryptophan and brain disorders
- Nonlinear Differential Equations Analysis
- Stress Responses and Cortisol
- Nerve injury and regeneration
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Metamaterials and Metasurfaces Applications
- Ginseng Biological Effects and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects of Natural Compounds
- Neurogenesis and neuroplasticity mechanisms
- Magnolia and Illicium research
- Gold and Silver Nanoparticles Synthesis and Applications
- Bioactive Natural Diterpenoids Research
- Numerical methods in inverse problems
- Geometric Analysis and Curvature Flows
- Orbital Angular Momentum in Optics
- Circadian rhythm and melatonin
- Differential Equations and Boundary Problems
- Advanced Mathematical Physics Problems
- Curcumin's Biomedical Applications
- Cancer-related cognitive impairment studies
- Plasmonic and Surface Plasmon Research
Institute of Genetics and Developmental Biology
2025
Center for Agricultural Resources Research
2025
Huaqiao University
2012-2024
Lanzhou University
1992-2024
Beijing University of Chinese Medicine
2014-2023
Kunming University of Science and Technology
2021
South China Normal University
2001-2017
Jilin University
2009
Union Hospital
2009
China Pharmaceutical University
2009
Although previous study has demonstrated that brain-derived neurotrophic factor (BDNF) is involved in the antidepressant-like effect of oleanolic acid, there little information regarding details molecular mechanism this effect.We used a chronic unpredictable mild stress (CUMS) model to test acid on depressant-like behaviour, miR-132 expression and synaptic protein male mouse hippocampus. Furthermore, we explored possible signalling pathways associated with mediate neuronal proliferation.The...
Abstract Previous studies have demonstrated that the mammalian target of rapamycin (mTOR) signaling pathway has an important role in ketamine-induced, rapid antidepressant effects despite acute administration fluoxetine not affecting mTOR phosphorylation brain. However, long-term treatment on modulation been assessed to date. In present study, we examined whether fluoxetine, a type commonly used agent, alters following chronic different brain regions, including frontal cortex, hippocampus,...
Cisplatin, a commonly used chemotherapy drug, can increase the survival rate of cancer patients. However, it often causes various side effects, including neuronal deficit-induced cognitive impairment. Considering that curcumin is effective in protection, action on improvement was evaluated cisplatin-treated C57BL/6 mice present study. Our results first showed restored impaired behaviors. Consistent with this, neurogenesis and synaptogenesis were improved by curcumin. In addition,...
Background . Our previous study has demonstrated that nobiletin could reverse the behavioral alterations in stressed mice. However, relation of its antidepressant-like action with neurotrophic molecular expression remains unknown. This aimed to explore mechanism related system rats exposed chronic unpredictable mild stress (CUMS). Methods Depressive-like anhedonia (assessed by sucrose preference) and serum corticosterone secretion were evaluated CUMS, followed brain-derived factor (BDNF),...
As a classical herb pair in clinics of traditional Chinese medicine, Curcumae Rhizoma-Sparganii Rhizoma (HP CR-SR) is used for activating blood circulation to remove stasis. The essential components HP CR-SR and its single herbs were comparatively analyzed using gas chromatography-mass spectrometry data. 66, 22, 54 volatile oils Rhizoma, Sparganii identified, total contents accounted 75.416%, 91.857%, 79.553% respectively. thirty-eight found CR-SR, not detected Rhizoma. highest radical...
<i>Syzygium aromaticum</i> has been widely used in traditional medicine. Our study investigated the safety and antidepressant-like effects of essential oil <i>S. after acute or long-term treatment. Using GC-MS, a total eight volatile constituents were identified aromaticum</i>. The single LD<sub>50</sub> was approximately 4500 mg/kg based on 24-h oral toxicity study. In repeated this (100, 200, 400 mg/kg, p. o.), only induced significant decrease body weight. addition, no changes relative...
Flavone C-glycosides are difficult to be deglycosylated using traditional chemical methods due their solid carbon-carbon bond between sugar moieties and aglycones; however, some bacteria may easily cleave this because they generate various specific enzymes.A bacterial strain, named W12-1, capable of deglycosylating orientin, vitexin, isovitexin aglycones, was isolated from human intestinal in study identified as Enterococcus faecalis based on morphological examination, physiological...
The study aimed to explore the antidepressant-like effect of oleanolic acid and its possible mechanism related monoaminergic system neurotrophin in mice exposed repeated forced swimming test (FST). Both duration latency immobility affected by (10, 20 40 mg/kg) were evaluated FST at intervals on days 1, 7 14, followed neurochemical brain-derived neurotrophic factor (BDNF) analyses mouse brain regions frontal cortex whole hippocampus. A analysis variance (ANOVA) indicated that over retesting...