A5101949730- 3D Printing in Biomedical Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Additive Manufacturing and 3D Printing Technologies
- Liver physiology and pathology
- Inflammasome and immune disorders
- Adipose Tissue and Metabolism
- Manufacturing Process and Optimization
- Alcohol Consumption and Health Effects
- Air Quality and Health Impacts
- Tissue Engineering and Regenerative Medicine
- Gout, Hyperuricemia, Uric Acid
- Industrial Technology and Control Systems
- Adipokines, Inflammation, and Metabolic Diseases
- Civil and Geotechnical Engineering Research
- Traffic control and management
- Traditional Chinese Medicine Analysis
- Thermography and Photoacoustic Techniques
- Diabetes Treatment and Management
- Advanced Cellulose Research Studies
- Polysaccharides Composition and Applications
- Spondyloarthritis Studies and Treatments
- Seaweed-derived Bioactive Compounds
- Lipid metabolism and biosynthesis
- Cellular Mechanics and Interactions
Nantong University
2025
Xi'an Jiaotong University
2005-2024
Tianjin University of Science and Technology
2024
South China University of Technology
2023
Huaqiao University
2019-2022
Nanchang University
2007-2021
China XD Group (China)
2020
Tiangong University
2015
Tsinghua University
2004-2008
Materials Processing (United States)
2008
Using rapid prototyping technology, three-dimensional (3D) structures composed of hepatocytes and gelatin hydrogel have been formed. This technique employs a highly accurate 3D micropositioning system with pressure-controlled syringe to deposit cell/biomaterial lateral resolution 10 µm. The pressure-activated micro-syringe is equipped fine-bore exit needle for which wide variety patterns different arrays channels (through-holes) were created. More than 30 layers hepatocyte/gelatin mixture...
Major depressive disorder is characterized by not only monoamine neurotransmitters deficiencies but also persistent neuroinflammation. The complement system an attractive therapeutic target for various inflammation-related diseases due to its early activation in inflammatory processes.In the present study, dynamic alteration of C3 and receptor C3aR during occurrence depression mechanism astrocyte-microglia IL-1R/C3/C3aR on synaptic pruning were investigated. proteomic analysis firstly showed...
Cisplatin, a commonly used chemotherapy drug, can increase the survival rate of cancer patients. However, it often causes various side effects, including neuronal deficit-induced cognitive impairment. Considering that curcumin is effective in protection, action on improvement was evaluated cisplatin-treated C57BL/6 mice present study. Our results first showed restored impaired behaviors. Consistent with this, neurogenesis and synaptogenesis were improved by curcumin. In addition,...
Lagotis brachystachya Maxim is a characteristic herb commonly used in Tibetan medicine. medicine records it as an important for the clinical treatment of "Yellow Water Disease," symptoms which are similar to that arthritis. Our previous study showed flavonoid fraction extracted from L. could attenuate hyperuricemia. However, effects active flavonoids on gouty arthritis remain elusive, and underlying mechanism not understood. In present study, were evaluated rats or Raw264.7 cells with...
The role of inflammation in psychiatric disorders, such as anxiety, has gained increasing attention, with the hippocampus being identified a key region involved emotional regulation. Argon been reported to alleviate symptoms disorders; however, its underlying mechanism remains unclear. In this study, we found that argon significantly suppressed lipopolysaccharide (LPS)-induced anxiety-like behaviors and attenuated hippocampal neuronal hyperexcitability mice. By analyzing excitability...
Objective Capillary leak syndrome (CLS) is an urgent problem in postoperative patients, challenging to diagnose early, and has a poor prognosis. We investigated quick convenient diagnostic indicator of secondary CLS children after cardiopulmonary bypass (CPB). Methods conducted this single-center, observational, prospective study the Department Critical Care Medicine at Children's Hospital Chongqing Medical University. All data were collected within 24 h The risk factors determined using...
Gynostemma pentaphyllum is a herbal medicine widely used in Asian countries, and its saponin extracts have been shown to possess potent anti-inflammatory effects. Gypenoside XVII, an active ingredient isolated from pentaphyllum, has found alleviate the inflammation induced by LPS BV2 microglia, according our preliminary study. This study aims evaluate whether XVII could attenuate depression-like symptoms vivo tries demonstrate involvement of complement regulation antidepressant-like effect....
To form 3D structures with composites of living cells and hydrogel is now becoming an attractive technology in both bioengineering manufacturing areas. Variant processes have been presented, most which are based on the cell composite extrusion deposition technique. So, design nozzle turns into important phase, rheological properties cell-hydrogel act as a key parameter must be well investigated. In this paper, entrance pressure detection device adaptor for small-diameter tips were developed....
Introduction Degraded porphyran is a bioactive polysaccharide extracted from Porphyra haitanensis ( P. ). According to the previous studies, it produced anti‐inflammatory activity, but little known about its effects on depression. Methods and Results As inflammation one of critical factors involved in development depression, this study aims elucidate potential antidepressant‐like degraded porphyran. The results show that acute treatment decreased immobility time despair tests. In addition,...
The incidence of diabetes–associated cognitive dysfunction is increasing. However, few clinical interventions are available to prevent the disorder. Several researches have shown that liraglutide, as a glucagon-like peptide-1 analog, has protective effects on various neurodegenerative diseases, but its roles in diabetic rarely reported. This study aims investigate liraglutide and underlying mechanisms. In vivo, treatment were investigated mouse model type 2 diabetes mellitus (T2DM). vitro,...
Much progress has been made in the pharmacology of Traditional Chinese Medicine (TCM). However, question on how to investigate pharmacokinetics TCM extract remains. In this study, we selected a new YL2000 developed our laboratory as research object and investigated both baicalin berberine pharmacodynamics febrile rats. The correlation analysis between time-concentration curves time-effect curve was conducted plasma by statistical methods. results showed that data anti-pyretic effect had...
Low-dose alcohol protected HFD-induced obese mice from the augmentation of anxiety-related behavior, which might be related to APN upregulation and Nrf2 activation.
The general toxicity of fine particulate matter (PM2.5) has been intensively studied, but its pulmonary toxicities are still not fully understood. To investigate the changes lung tissue after PM2.5 exposure and identify potential mechanisms toxicity, samples were firstly collected analyzed. Next, different doses (5 mg/kg, 10 20 mg/kg) intratracheally instilled into rats to simulate inhalation polluted air. After instillation for eight weeks, morphological alterations examined, levels...
The relationship between low-dose alcohol consumption and lipid metabolism has been extensively studied during the last few decades. It reported that upregulates expression of peroxisome proliferator-activated receptor γ (PPARγ), a vital nuclear transcription factor involved in glucose metabolism. However, possible molecular mechanism remains unclear. In present study, obese mouse model was established by HFD feeding for 12 weeks, then administered 4 weeks. results showed ameliorated...
This paper extracts the 2D Poisson equation in subthreshold area by means of a quasi-tripod approximation longitudinal potential distribution silicon film FD-SOI device; thus formulas both front and back interface device are obtained. Through introduction modified parameters thesis constructs surface model front/back deep submicron FD device. The can directly reflect DIBL effect, all based on physics, non-infinite series or iterative processes need to be led in, so it has little calculating...