FENDRR is a long non-coding RNAs (lncRNA) that binds to polycomb repressive complexe 2 (PRC2) epigenetically regulate the expression of its target gene. The clinical role in carcinomas remains yet be found.Real-time polymerase chain reaction (PCR) was used examine gastric cancer cell lines/tissues compared with normal epithelial cells/adjacent non-tumorous tissues. Cell proliferation assays, Wound healing and vitro vivo invasion migration assays were performed detect biological effects...

Long noncoding RNAs (lncRNA) are a novel class of transcripts with no protein coding capacity, but diverse functions in cancer cell proliferation, apoptosis, and metastasis. The lncRNA PVT1 is 1,716 nt length located the chr8q24.21 region, which also contains myelocytomatosis (MYC) oncogene. Previous studies demonstrated that MYC promotes expression primary human cancers. However, pattern potential biologic function non-small lung (NSCLC) still unclear. Here, we found was upregulated 105...

Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related death, especially in China. And mechanism its progression remains poorly understood. Growing evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated many cancers, including HCC. ANRIL, a lncRNA co-clustered mainly with p14/ARF has been reported gastric cancer, esophageal squamous cell carcinoma, and lung cancer. However, clinical significance potential role HCC still not documented.In this...

Recently, long noncoding RNAs have been emerged as critical regulators of human disease and prognostic markers in several cancers, including gastric cancer. In this study, we globally assessed the transcriptomic differences lncRNAs cancer using publicly available microarray data from Gene Expression Omnibus (GEO) identified an oncogenetic lncRNA ZFAS1, which may promote tumorigenesis. ZFAS1 has found to be upregulated function oncogene colorectal hepatocellular carcinoma, but its expression...

Background: Nowadays, despite great progress in cancer research, the detailed mechanisms of colorectal (CRC) are still poorly understood. Circular RNAs (circRNAs), a new star non-coding RNA network, have been identified as critical regulators various cancers, including CRC. Methods and results: In this study, by using unsupervised hierarchical clustering analysis, novel dysregulated circRNA, hsa_circ_0000069, was found. The expression hsa_circ_0000069 measured 30 paired CRC tissues adjacent...

Long noncoding RNAs (lncRNAs) have emerged as important regulators in a variety of human diseases, including cancers. However, the biological function these molecules and mechanisms responsible for their alteration gastric cancer (GC) are not fully understood. In this study, we found that lncRNA LINC00673 is significantly upregulated cancer. Knockdown inhibited cell proliferation invasion induced apoptosis, whereas overexpression had opposite effect. Online transcription factor binding site...

Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related death, especially in China. And mechanism its progression remains poorly understood. Growing evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated many cancers, including HCC. CDKN2B antisense RNA1 (ANRIL), a lncRNA, coclustered mainly with p14/ARF has been reported gastric cancer, esophageal squamous cell carcinoma, and lung cancer. However, clinical significance potential role HCC still...

// Wen-ming Chen 1, * , Ming-de Huang 2, Dao-ping Sun Rong Kong 3 Tong-peng Xu 4 Rui Xia 5 Er-bao Zhang Yong-qian Shu 1 Department of Oncology, Jining NO.1 People's Hospital, City, Shandong Province 272011, China 2 Medical Huai'an First Nanjing University, Jiangsu 223300, Central Laboratory, Subei Hospital province, Yangzhou, 225001, The Affiliated Nanjing, 210029, Biochemistry and Molecular Biology, These authors have contributed equally to this work Correspondence to: Shu, e-mail:...

Abstract Recent evidence indicates that E2F1 transcription factor have pivotal roles in the regulation of cellular processes, and is found to be dysregulated a variety cancers. Long non-coding RNAs (lncRNAs) are also reported exert important effect on tumorigenesis. aberrantly expressed gastric cancer (GC), biology functions GC controversial. The biological characteristics correlation between lncRNAs remain found. In this study, integrated analysis revealed expression was significantly...

Computed tomography (CT)-guided pulmonary core biopsies of small nodules less than 15 millimeters (mm) are challenging for radiologists, and their diagnostic accuracy has been shown to be variable in previous studies. Common complications after the procedure include pneumothorax hemorrhage. The present study compared large lesions using CT-guided identified risk factors associated with post-procedure complications. Between January 1, 2016, December 31, 2017, 198 performed on 195 patients at...

Abstract Recent findings indicate that long noncoding RNA s (lnc s) were dysregulated in many kinds of tumors including esophageal squamous cell carcinoma ( ESCC ). Lnc AFAP 1‐ AS 1 was found to be upregulated hepatocellular HCC ), lung cancer, colorectal adenocarcinoma EAC pancreatic ductal adenocarcinoma, and nasopharyngeal carcinoma, while its clinical value potential function are still unknown. Expression measured 65 tissues corresponding noncancerous by quantitative real‐time polymerase...

Neutrophils release neutrophil extracellular traps (NETs), a reticular structure mainly composed of antimicrobial peptides, DNA, and histones. Neutrophil elastase (NE), matrix metalloproteinase- 9, histone G are the key components NETs critically involved in breast cancer invasion migration, which suggests an important role tumorigenesis metastasis. Studies have reported that significantly promote invasion, intravascular infiltration, distant metastasis by inducing epithelial-mesenchymal...

Abstract Background Recently, the pesudogenes have emerged as critical regulators in human cancers tumorigenesis and progression, been identified a key revelation post-genomic biology. However, expression pattern, biological function mechanisms responsible for these molecules gastric cancer (GC) are not fully understood. Methods In this study, we globally assessed transcriptomic differences of using publicly available microarray data. DUXAP10 levels GC tissues cells was detected quantitative...

Background MiR-378 has been reported to be related cell survival, tumor growth and angiogenesis may participate in hepatocellular carcinoma (HCC) development prognosis. Genetic variants primary miR-378 (pri-miR-378) impact expression contribute HCC risk survival. This study aimed assess the associations between a genetic variant susceptibility Methods We conducted case-control analyze association of rs1076064 pri-miR-378 with 1300 patients positive hepatitis B virus (HBV) 1344 HBV carriers....

Background MiR-106b-25 cluster, hosted in intron 13 of MCM7, may play integral roles diverse processes including immune response, tumorigenesis and progression. A single nucleotide polymorphism (SNP), rs999885, is located the promoter region MCM7. Our previous study showed that to G base change rs999885 provide an increased risk for HCC HBV persistent carriers by altering expression miR-106b-25 cluster. However, it unknown whether associated with prognosis intermediate or advanced...

Certain pseudogenes may regulate their protein-coding cousins by competing for miRNAs and play an active biological role in cancer. However, few studies have focused on the association of genetic variations with cancer prognosis. We selected six potentially functional single nucleotide polymorphisms (SNPs) cancer-related pseudogenes, performed a case-only study to assess between those SNPs prognosis hepatocellular carcinoma (HCC) 331 HBV-positive HCC patients without surgical treatment....

NBS1 plays a key role in the repair of DNA double-strand break (DSB). We conducted this study to investigate effect two critical polymorphisms (rs1805794 and rs13312840) on treatment response prognosis advanced non-small cell lung cancer (NSCLC) patients with platinum-based chemotherapy.Using TaqMan methods, we genotyped 147 NSCLC patients. Odds ratios (ORs) their 95% confidential intervals (CIs) were calculated as measure difference rate chemotherapy using logistic regression analysis. The...

In the present study, a hypoxia/reoxygenation (H/R) model of cardiomyocytes was established to investigate effects long non-coding RNA (LncRNA) Nuclear Enriched Abundant Transcript 1 (NEAT1) and microRNA (miR)-520a on H/R-induced cardiomyocyte apoptosis. Flow cytometry terminal deoxynucleotidyl transferase dUTP nick end labeling staining were used evaluate cell Luciferase activity assay whether miR-520a targets NEAT1. Results revealed that NEAT1 significantly upregulated downregulated in...

This meta-analysis aimed to determine whether interferon (IFN) therapy could improve clinical effects of patients with chronic hepatitis B virus (HBV)or C (HCV) infection-related primary hepatocellular carcinoma (HCC) after surgery.An electronic search from January 1998 December 2012 was conducted identify comparative studies evaluating IFN on recurrence and survival surgical treatment HCC.The estimated odds ratios (OR) for the 1-, 2-, 3- 5-year overall rates HBV-related HCC were 3.37 (95%...

Triple-negative breast cancer (TNBC) remains the most incurable subtype of owing to high heterogeneity, aggressive nature, and lack treatment options. It is generally acknowledged that epithelial-mesenchymal transition (EMT) key step in tumor metastasis. With application TCGA GEO databases, we identified EMT-related lncRNAs by Cox univariate regression analysis. Optimum risk scores were calculated used divide TNBC patients into high-/low-risk subgroups median value using Lasso The...