A5012952780- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Advancements in Battery Materials
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Catalytic Processes in Materials Science
- Medicinal plant effects and applications
- Catalysis and Oxidation Reactions
- Advanced Battery Materials and Technologies
- Hydrocarbon exploration and reservoir analysis
- Glutathione Transferases and Polymorphisms
- Graphene research and applications
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Fiber-reinforced polymer composites
- Catalysis and Hydrodesulfurization Studies
- Retinoids in leukemia and cellular processes
- Epigenetics and DNA Methylation
- Nanomaterials for catalytic reactions
- Acute Myeloid Leukemia Research
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Petroleum Processing and Analysis
- Geological Studies and Exploration
- Genomic variations and chromosomal abnormalities
Eastern Liaoning University
2022-2025
University of Houston
1995-2024
Research Network (United States)
2024
Shenyang Normal University
2024
China University of Petroleum, Beijing
2021-2023
The University of Texas MD Anderson Cancer Center
2016-2023
University of Electronic Science and Technology of China
2020-2022
Shanghai Institutes for Biological Sciences
2010-2014
Shanghai Jiao Tong University
2014
University of Chinese Academy of Sciences
2014
Long noncoding RNAs (lncRNA) have been implicated in human cancer but their mechanisms of action are mainly undocumented. In this study, we investigated lncRNA alterations that contribute to gastric through an analysis The Cancer Genome Atlas RNA sequencing data and other publicly available microarray data. Here report the cancer-associated HOXA11-AS as a key regulator development progression. Patients with high expression had shorter survival poorer prognosis. vitro vivo assays revealed...
Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge gap, we perform a genome-wide CRISPR dropout screen and integrate analyses multi-omics data screen, association studies, single-cell RNA-Seq, host-virus proteins or protein/RNA interactome. This study uncovers many that currently underappreciated, including components V-ATPases, ESCRT,...
Long noncoding RNAs (lncRNAs) have emerged as important regulators in a variety of human diseases, including cancers. However, the biological function these molecules and mechanisms responsible for their alteration gastric cancer (GC) are not fully understood. In this study, we found that lncRNA LINC00673 is significantly upregulated cancer. Knockdown inhibited cell proliferation invasion induced apoptosis, whereas overexpression had opposite effect. Online transcription factor binding site...
Translation is principally regulated at the initiation stage. The development of translation (TI) sequencing (TI-seq) technique has enabled global mapping TIs and revealed unanticipated complex translational landscapes in metazoans. Despite wide adoption TI-seq, there no computational tool currently available for analyzing TI-seq data. To fill this gap, we develop a comprehensive toolkit named Ribo-TISH, which allows detecting quantitatively comparing across conditions from Ribo-TISH can...
Recently, the non-protein-coding functional elements in human genome have been identified as key regulators postgenomic biology, and a large number of pseudogenes well long non-coding RNAs (lncRNAs) found to be transcribed multiple cancers. However, only small proportion these has functionally characterized. In this study, we screened for associated with non-small-cell lung cancer (NSCLC) by comparative analysis several independent datasets from GEO. We pseudogene named DUXAP8 that is...
The glioblastoma (GBM) stem cell–like cells (GSCs) are critical for tumorigenesis/therapeutic resistance of GBM. Mounting evidence supports tumor-promoting function long noncoding RNAs (lncRNAs), but their role in GSCs remains poorly understood. By combining CRISPRi screen with orthogonal multiomics approaches, we identified a lncRNA DARS1-AS1 –controlled posttranscriptional circuitry that promoted the malignant properties GBM cells/GSCs. Depleting inhibited proliferation cells/GSCs and...
Emerging evidence suggests that cryptic translation within long noncoding RNAs (lncRNAs) may produce novel proteins with important developmental/physiological functions. However, the role of this in complex diseases (e.g., cancer) remains elusive. Here, we applied an integrative strategy combining ribosome profiling and CRISPR/Cas9 screening large-scale analysis molecular/clinical data for breast cancer (BC) identified estrogen receptor α–positive (ER+) BC dependency on ORFs encoded by...
Cu-ZSM-5 zeolites exhibit promising NH3-SCR activity in a wide temperature window. The current challenges preparing are reducing the cost and simplifying preparation process. one-pot method using Cu-amine complex as template is an excellent strategy for solving above problems. However, still lacking Cu-ZSM-5. In this work, Cu-(EDA)2 developed to prepare Cu-ZSM-5-O catalyst. According fundamental measurements, high dispersion of copper(II) species, appropriate acidity, Cu+ species favor...
Background Despite approval of immunotherapy for a wide range cancers, the majority patients fail to respond or relapse following initial response. These failures may be attributed immunosuppressive mechanisms co-opted by tumor cells. However, it is challenging use conventional methods systematically evaluate potential intrinsic factors act as immune regulators in with cancer. Methods To identify non-responders cancer an unbiased manner, we performed genome-wide CRISPR screens and integrated...
Protein arginine methyltransferases (PRMT) are a widely expressed class of enzymes responsible for catalyzing methylation on numerous protein substrates. Among them, type I PRMTs generating asymmetric dimethylarginine. By controlling multiple basic cellular processes, such as DNA damage responses, transcriptional regulation, and mRNA splicing, contribute to cancer initiation progression. A PRMT inhibitor, GSK3368715, has been developed entered clinical trials solid hematologic malignancies....
Hyperactivated protein arginine methyltransferases (PRMTs) are implicated in human cancers. Inhibiting tumor intrinsic PRMT5 was reported to potentiate antitumor immune responses, highlighting the possibility of combining inhibitors (PRMT5i) with cancer immunotherapy. However, global suppression activity impairs effector functions cells. Here, we sought identify strategies specifically inhibit tissues and develop effective PRMT5i-based immuno-oncology (IO) combinations for treatment,...
In this paper, GH4079 alloy was thermally compressed under processing conditions of 1025 °C–1200 °C and 0.001 s−1–1 s−1. This article established the strain compensation Arrhenius constitutive equation, improved Johnson–Cook model based on phase transition temperature segmentation calculated correlation coefficient (R) local relative error (AARE) to verify accuracy model, respectively. Finally, a certain microstructural analysis combined. It can be concluded that rheological stress gradually...
Adenanthin, a natural diterpenoid isolated from the leaves of Isodon adenanthus, has recently been reported to induce leukemic cell differentiation by targeting peroxiredoxins (Prx) I and II. On other hand, increasing lines evidence propose that these Prx proteins would become potential targets screen drugs for prevention treatment solid tumors. Therefore, it is significance explore activities adenanthin on tumor cells. Here, we demonstrate protein essential survival hepatocellular carcinoma...
Autophagy is a highly conserved, closely regulated homeostatic cellular activity that allows for the bulk degradation of long-lived proteins and cytoplasmic organelles. Its roles in cancer initiation progression determining response tumor cells to anticancer therapy are complicated, only limited investigation has been conducted on potential significance autophagy pathogenesis therapeutic acute myeloid leukemia. Here we demonstrate inducible or transfected expression promyelocytic leukemia...