A5015057987- Genetic Neurodegenerative Diseases
- Rice Cultivation and Yield Improvement
- Muscle Physiology and Disorders
- GABA and Rice Research
- Adenosine and Purinergic Signaling
- Nuclear Receptors and Signaling
- Galectins and Cancer Biology
- Macrophage Migration Inhibitory Factor
- Muscle metabolism and nutrition
- Acute Myeloid Leukemia Research
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Mitochondrial Function and Pathology
- Retinoids in leukemia and cellular processes
- Plant responses to water stress
- RNA modifications and cancer
University of Groningen
2024-2025
Yangzhou University
2013
Shanghai Jiao Tong University
2010-2011
Ruijin Hospital
2010
The expression of galectin-1, one the most important lectins participating in malignant tumor development, has been shown to be regulated by hypoxia, but its exact mechanism remains elusive. Here, we find that ectopically expressed hypoxia-inducible factor (HIF) 1α protein, an oxygen-sensitive subunit HIF-1 is a master for cellular response significantly increases galectin-1 both messenger RNA and protein levels all four colorectal cancer (CRC) cell lines tested. However, hypoxia-induced...
Knowledge on the performance in grain yield and physiological traits is essential to understand main yield-limiting factor make strategies for breeding crop management rice (Oryza sativa L.). This study investigated changes associated of Yangtze River Basin China during last 60 yr. Thirteen mid-season indica 12 japonica cultivars that were popularly used grown field 2008 2009. The components, biomass, leaf area, photosynthesis, root oxidation activity, harvest index examined. results showed...
Abstract Ferroptosis is a form of regulated cell death that can be modulated by small molecules and has the potential for development therapeutics oncology. Although excessive lipid peroxidation defining hallmark ferroptosis, DNA damage may also play significant role. In this study, mechanistic role MIF in homologous recombination (HR) repair identified. The inhibition or genetic depletion other HR proteins, such as breast cancer type 1 susceptibility protein (BRCA1), demonstrated to...
Autophagy is a highly conserved, closely regulated homeostatic cellular activity that allows for the bulk degradation of long-lived proteins and cytoplasmic organelles. Its roles in cancer initiation progression determining response tumor cells to anticancer therapy are complicated, only limited investigation has been conducted on potential significance autophagy pathogenesis therapeutic acute myeloid leukemia. Here we demonstrate inducible or transfected expression promyelocytic leukemia...
Abstract Huntington’s disease (HD) is a neurodegenerative disorder in which mutated fragments of the huntingtin protein (Htt) undergo misfolding and aggregation. Since aggregated proteins can cause cellular stress cytotoxicity, there an interest development small molecule aggregation inhibitors as potential modulators HD pathogenesis. Here, we study how polyphenol modulates mechanism exon 1 (HttEx1) even at sub-stoichiometric ratios. Sub-stoichiometric amounts curcumin impacted primary...
Abstract Huntington’s disease (HD) is a neurodegenerative disorder in which mutated fragments of the huntingtin protein (Htt) undergo misfolding and aggregation. Since misfolded aggregated proteins can cause cellular stress cytotoxicity, there an interest development small molecule aggregation inhibitors as potential modulators HD pathogenesis. Here, we study how polyphenol modulates mechanism exon 1 (HttEx1) even at sub-stoichiometric ratios. Sub-stoichiometric amounts curcumin impacted...