A5101715684- Drug Solubulity and Delivery Systems
- Endoplasmic Reticulum Stress and Disease
- Advanced Drug Delivery Systems
- Autophagy in Disease and Therapy
- Drug Transport and Resistance Mechanisms
- Herpesvirus Infections and Treatments
- Natural Antidiabetic Agents Studies
- Medicinal plant effects and applications
- Crystallization and Solubility Studies
- Ginseng Biological Effects and Applications
- Gut microbiota and health
- Fungal and yeast genetics research
- Hepatitis B Virus Studies
- Plant Molecular Biology Research
- vaccines and immunoinformatics approaches
- Cervical Cancer and HPV Research
- Pharmacogenetics and Drug Metabolism
- Viral Infections and Outbreaks Research
- Poxvirus research and outbreaks
- Photosynthetic Processes and Mechanisms
- Cancer-related molecular mechanisms research
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Chemistry and Chromatography
- RNA modifications and cancer
- Rabies epidemiology and control
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2024
China Medical University
2014-2024
Shandong University
2024
Peking Union Medical College Hospital
2020-2022
Jilin Agricultural University
2022
Sheng Jing Hospital
2022
Zhujiang Hospital
2022
First Hospital of Jilin University
2022
Jilin University
2022
University at Buffalo, State University of New York
2020
The unfolded protein response (UPR) is activated to sustain cell survival by reducing misfolded accumulation in the endoplasmic reticulum (ER). UPR also promotes programmed death (PCD) when ER stress severe; however, underlying molecular mechanisms are less understood, especially plants. Previously, two membrane-associated transcriptions factors (MTFs), bZIP28 and bZIP60, were identified as key regulators for plant response. Here, we report identification of another MTF, NAC089, an important...
The unfolded protein response (UPR) plays important roles in plant development and plant-pathogen interactions, as well adaptation to adverse environmental stresses. Previously bZIP28 bZIP60 have been identified UPR regulators for mitigating the endoplasmic reticulum (ER) stress Arabidopsis thaliana. Here we report biological function of NAC103 a novel transcriptional regulatory cascade, connecting downstream genes Arabidopsis. Expression was induced by ER stress, completely abolished null...
Significance In metazoans, pausing of Pol II during early elongation is a widespread regulatory mechanism for transcription regulation. However, preinitiation complex (PIC) assembly more important in plants. Chromatin remodeling and histone modifications are considered access protein factors to the underlying DNA sequences. how specifically timely generated at active promoters less understood. COMPASS-like plays critical role PIC H3K4 trimethylation. We found that Arabidopsis bZIP28/bZIP60...
Gut microbiota has been implicated in the pharmacological activities of many natural products. As an effective hypolipidemic agent, berberine (BBR)'s clinical application is greatly impeded by obvious inter-individual response variation. To date, little evidence exists on causality between gut microbes and its therapeutic effects, linkage bacteria alterations to variation.This study aims confirm causal role BBR's anti-hyperlipidemic effect identify key that can predict effectiveness.The...
Intestinal microbiota is a novel drug target of metabolic diseases, especially for those with poor oral bioavailability. Nuciferine, bioavailability, has an anti-hyperlipidemic effect at low dosages. In the present study, we aimed to explore role intestinal in function nuciferine and identify key bacterial targets that might confer therapeutic actions. The contribution gut microbes was evaluated by conventional antibiotic-established pseudo-sterile mice. Whole-metagenome shotgun sequencing...
With the high incidence of obesity around globe, potential role bile acid metabolism and gut microbiota in modulating aroused great enthusiasm. Here we studied anti-obesity effect dihydromyricetin (DHM), main biologically active component Ampelopsis grossedentata, which was applied for thousands years form tea beverages. A 12-week treatment DHM significantly reduced body weight gain ob/ob mice. Meanwhile, serum parameters that are closely associated with obesity, including levels total...
Two salt hypersensitive mutants she1 and she2 were identified through genetic screening. SHE1 encodes a cellulose synthase CESA6 while SHE2 synthase-interactive protein CSI1. Both of them are involved in deposition. Our results demonstrated that the sustained synthesis is important for stress tolerance Arabidopsis.
Summary Abscisic acid plays important roles in maintaining seed dormancy while gibberellins ( GA ) and other phytohormones antagonize ABA to promote germination. However, how signaling is desensitized during the transition from germination still poorly understood. We functionally characterized role of membrane‐associated transcription factor peptidase, site‐2 protease (S2P), Arabidopsis. Genetic analysis showed that loss‐of‐function S2P conferred high sensitivity germination, expression...
Vine tea (VT), derived from Ampelopsis grossedentata (Hand.-Mazz.) W.T. Wang, is an alternative that has been consumed widely in south China for hundreds of years. It shown drinking VT on a daily basis improves hyperlipidemia and hyperglycemia. However, little known about the preventive functions metabolic dysregulation potential pathological mechanisms involved. This paper elucidates effects lipid glucose metabolism using rats maintained high-fat-diet (HFD) attempt to explain...
Many sources of stress cause accumulation unfolded or misfolded proteins in endoplasmic reticulum (ER), which elicits the protein response (UPR) to either promote cell survival programmed death depending on different developmental context severity. The Arabidopsis membrane-associated transcription factor, bZIP28, is functional equivalent mammalian ATF6, relocates from ER Golgi where it proteolytically processed and released membrane nucleus mediate UPR. Although canonical site-1 protease...
Cardiovascular diseases (CVDs), including thrombosis, which is induced by platelet aggregation, are the leading cause of mortality worldwide. The P2Y1 receptor (P2Y1R) facilitates aggregation and thus an important potential anti-thrombotic drug target. P2Y1R protein structure contains a binding site for antagonist MRS2500 within its seven-transmembrane bundle, also provides suitable pockets numerous other ligands to act as nucleotide antagonists P2Y1R. Traditional Chinese Medicine Systems...
Blood and multitissue concentration-time profiles for dexamethasone (DEX), a synthetic corticosteroid, were measured in male rats after subcutaneous bolus infusion dosing. A physiologically based pharmacokinetics (PBPK) model was applied 12 tissues. Tissue partition coefficients (<i>K</i><sub><i>p</i></sub>) metabolic clearance assessed from studies. cell to plasma partitioning (0.664) free fraction (0.175) DEX found be moderate. extensively partitioned into liver...
Human effective intestinal membrane permeability (Peff) is one of the two important indicators for drug classification according to Biopharmaceutical Classification System (BCS), and contributes greatly performance oral absorption. Here, a structure-based in silico predictive model Peff was developed successfully facilitate BCS early stage discovery, even before compound synthesized. The quantitative structure-Peff relationship 30 drugs constructed based on seven structural parameters. Then...