Hyperlipidemia is considered to be one of the greatest risk factors contributing prevalence and severity cardiovascular diseases. In this work, we investigated anti-hyperlipidemic effect potential mechanism action Pandanus tectorius fruit extract in hamsters fed a high fat-diet (HFD). The n-butanol fraction P. ethanol (PTF-b) was rich caffeoylquinic acids (CQAs). Administration PTF-b for 4 weeks effectively decreased retroperitoneal fat serum levels total cholesterol (TC), triglycerides (TG)...

Chlorogenic acid (CGA) is one of the most abundant polyphenols in human diet and suggested to be a potential antiatherosclerotic agent due its proposed hypolipidemic, anti-inflammatory antioxidative properties. The aim this study was evaluate effect CGA on atherosclerosis development ApoE−/− mice mechanism. were fed cholesterol-rich without (control) or with (200 400 mg/kg) atorvastatin (4 for 12 weeks. During plasma lipid inflammatory parameters determined. Treatment (400 reduced...

Gut microbiota has been implicated in the pharmacological activities of many natural products. As an effective hypolipidemic agent, berberine (BBR)'s clinical application is greatly impeded by obvious inter-individual response variation. To date, little evidence exists on causality between gut microbes and its therapeutic effects, linkage bacteria alterations to variation.This study aims confirm causal role BBR's anti-hyperlipidemic effect identify key that can predict effectiveness.The...

Phytoestrogens are estrogen-like compounds of plant origin. The pharmacological activities phytoestrogens predominantly due to their antioxidant, anti-inflammatory and lipid-lowering properties, which mediated via the estrogen receptors (ERs): receptor alpha (ERα) beta (ERβ) possibly G protein-coupled 1 (GPER). Gypenoside XVII (GP-17) is a phytoestrogen that widely used prevent cardiovascular disease, including atherosclerosis, but mechanism underlying these therapeutic effects largely...

In our previous investigation, we found that agarwood essential oil (AEO) has a sedative-hypnotic effect. Sedative-hypnotic drugs usually have an anxiolytic effect, where concomitant anxiety and depression are common comorbidity. Therefore, this study further investigated the antidepressant effects of AEO using series animal behavior tests on restraint stress-induced mice model. The elevated plus maze (EPM) test, light dark exploration (LDE) open field (OF) test demonstrated significant...

The clonal spread of multiple drug-resistant Acinetobacter baumannii is an emerging problem in China. We analysed the molecular epidemiology baumanni isolates at three teaching hospitals and investigated risk factors, clinical features, outcomes hospital-acquired pneumonia caused by extensive (XDRAB) infection Guangzhou, Fifty-two A. were collected. Multilocus sequence typing (MLST) was used to assess genetic relationships among isolates. bla OXA-51-like gene amplified using polymerase chain...

Context: Chrysin, a natural flavonoid, has been shown to possess multiple pharmacological activities including anti-atherosclerosis.Objective: The effects of chrysin on foam cell formation and cholesterol flow in RAW264.7 macrophages were investigated this work explore the potential mechanism underlying its anti-atherogenic activity.Materials methods: inhibitive effect accumulation induced by oxidized low-density lipoprotein (ox-LDL) was assessed oil red O staining intracellular total...

Four new cyclic peptides, psychrophilins E–H (1–4), possessing a rare amide linkage between the carboxylic acid in anthranilic (ATA) and nitrogen from an indole moiety, along with ATA-containing hexapeptide, versicotide C (5), were obtained culture of marine-derived fungus Aspergillus versicolor ZLN-60. The structures, including absolute configurations, elucidated by combination HRESIMS, NMR, X-ray crystallography, TDDFT ECD calculations, Marfey's method. Versicotide (5) is first natural...

Asperlin is a marine-derived natural product with antifungal and anti-inflammatory activities in vitro. In the present study, we isolated asperlin from marine Aspergillus versicolor LZD4403 fungus investigated its anti-atherosclerotic effects vitro vivo. significantly inhibited lipopolysaccharides (LPS)- but not oxidated low-density lipoprotein (oxLDL)-evoked foam cell formation promoted cholesterol efflux RAW264.7 macrophages. Supplementation also suppressed LPS-elicited production of...

Chemical examination of a sponge (Cinachyrella sp.)-associated Emericella variecolor fungus resulted in the isolation seven new polyketide derivatives, namely, varioxiranols A–G (1–7), and hybrid PKS-isoprenoid metabolite, 19-O-methyl-22-methoxypre-shamixanthone (8), together with nine known analogues. Their structures were elucidated on basis extensive spectroscopic analyses, including ECD effects, Mosher's method, X-ray diffraction, chemical conversion for determination absolute...

Six new caryophyllene-based sesquiterpenoids named punctaporonins H–M (1–6), together with punctaporonin B (7) and humulane (8) were isolated from the fermentation broth of sponge-derived fungus Hansfordia sinuosae. Their structures determined by extensive HRESIMS NMR spectroscopic analysis, including X-ray crystallographic data for assignment absolute configurations H–I (1–2). The compounds evaluated antihyperlipidemic, cytotoxic antimicrobial activities, K (4) exhibited potent effects to...

Although agarwood has been used as a tranquilizer in Asian countries for hundreds of years, the underlying pharmacological basis is still unclear. This study investigated sedative-hypnotic effect essential oil (AEO) using locomotor activity and pentobarbital-induced sleeping assays mice. Single (1-day) multiple (7- 14-days) administrations 60 mg/kg AEO generated significant sedative on inhibiting hypnotic Interestingly, prolonged treatment did not result obvious desensitization. Concoitant...

The bitter melon (Momordica charantia) is a medical food with well-documented hypoglycemic and anti-hyperlipidemic activities. Previous studies showed that the M. charantia fruit (MC) could modulate gut microbiota, but whether this modulation essential for MC's pharmacological effects largely unknown. Here, we assessed causality of microbes in MC-elicited first time. Oral administration MC significantly prevented hyperlipidemia, amelioration substantially diminished when co-treated...

Antibiotic resistance nowadays is spreading much faster than the introduction of new antibiotics into clinical practice. There an urgent need for potential compounds to combat multidrug-resistant (MDR) bacteria. Marine fungi provide a promising source chemical diversity with antibiotic-like molecules. To identify structurally distinct that effectively eradicate MDR pathogens and control development antibiotic resistance, we have reinvestigated equisetin, previously reported meroterpenoid...

Sophoricoside, an isoflavone glycoside isolated from Sophora japonica (Leguminosae), has been widely reported as immunomodulator. In this study, the effects of sophoricoside on lipogenesis and glucose consumption in HepG2 cells C2C12 myotubes were investigated. Treatment with at concentrations 1–10 μM inhibited lipid accumulation a dose-dependent manner. At same concentration range, no effect cell viability was observed MTT assay. Inhibition associated downregulation SREBP-1a, SREBP-1c,...

Bioassay-guided evaluation shows that a deep sea-derived fungus, Spiromastix sp. MCCC 3A00308, possesses lipid-lowering activity. Chromatographic separation of culture broth resulted in the isolation 15 known depsidone-based analogues, labeled spiromastixones A-O (1-15). Each these compounds was tested for its ability to inhibit oxidized low-density lipoprotein (oxLDL)-induced foam cell formation RAW264.7 macrophages. Spiromastixones 6-8 and 12-14 significantly decreased oxLDL-induced lipid...

Six new pyridone alkaloids, named penipyridones A–F (1–6), were isolated from the fermentation broth of an Antarctic moss-derived fungus, Penicillium funiculosum GWT2-24. Their structures elucidated extensive NMR and MS data. Although they possess same major chromophore some them presented almost mirror ECD spectra, their absolute configurations found to be uniformly S, as evidenced by X-ray single-crystal diffraction analysis, stereocontrolled total synthesis, chemical conversions....

Adipose tissue inflammation and fibrosis appear to contribute insulin resistance in obesity. Vitamin D receptor (Vdr) genes are expressed by adipocytes, macrophages, fibroblasts, all of which could potentially play a role adipose fibrosis. As vitamin has been shown have direct anti-inflammatory effects on we determined whether specific receptor-mediated adipocytes impact ultimately resistance. We examined the repleting 25(OH)D-deficient, resistant, overweight-to-obese human subjects (n =...

Background. Agarwood has been used for centuries, especially treatment of gastrointestinal diseases. Earlier studies our laboratory suggested that agarwood alcohol extracts (AAEs) provided gastric mucosal protection. This study aims to investigate the ameliorative effect AAEs on ethanol-induced ulcers and its mechanism. Methods. Mice were given induced by whole-tree agarwood-inducing technique extract (WTAAE, 0.71, 1.42, 2.84 g/kg), wild axe wounds (WAAE, burning-chisel-drilling (FBAAE,...

Foam cells formation as a result of the uncontrolled cytophagy modified cholesterol by macrophages plays key role in occurrence and development atherosclerosis. Sesamin is an active constituent Sesamum indicum which has been shown to possess multiple pharmacological activities. In this work, we investigated effects sesamin on foam cell efflux RAW264.7 macrophages. dose-dependently inhibited enhanced accumulation elicited oxidized low-density lipoprotein (oxLDL) cells. Treatment with (10 μM)...