A5003743565- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Lung Cancer Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Tissue Engineering and Regenerative Medicine
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Gastric Cancer Management and Outcomes
- Cardiac Ischemia and Reperfusion
- SARS-CoV-2 detection and testing
- Kruppel-like factors research
- Genetic factors in colorectal cancer
- Systemic Lupus Erythematosus Research
- Infectious Encephalopathies and Encephalitis
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Rheumatoid Arthritis Research and Therapies
- Inflammatory Biomarkers in Disease Prognosis
Nanjing Medical University
2008-2024
Jiangsu Province Hospital
2017-2024
Zhejiang Academy of Forestry
2024
Tongde Hospital of Zhejiang Province
2023-2024
Jiangxi University of Traditional Chinese Medicine
2024
Harbin Medical University
2024
Third Affiliated Hospital of Harbin Medical University
2024
Huaian First People’s Hospital
2020
Ningbo No. 2 Hospital
2017
Recently, long non-coding RNAs (lncRNAs) are identified as new crucial regulators of diverse cellular processes, including cell proliferation, differentiation and cancer cells metastasis. Accumulating evidence has revealed that aberrant lncRNA expression plays important roles in carcinogenesis tumor progression. However, the pattern biological function lncRNAs non-small-cell lung (NSCLC) remain largely unknown. In this study, we performed comprehensive analysis human NSCLC samples by using...
Azvudine and nirmatrelvir-ritonavir are more extensively used to treat COVID-19 in China due their earlier approval by the National Medical Products Administration. However, there has been a scarcity of research directly comparing clinical outcomes between azvudine till now. We aimed make head-to-head comparison efficacy safety or hospitalized patients with China. This retrospective cohort study was conducted using data collected from Tongde Hospital Zhejiang Province December 2022 January...
Several studies by microarray analysis and real-time polymerase chain reaction (RT-PCR) reveal that type I interferon-inducible genes (IFIGs) are implicated in systemic lupus erythematosus (SLE). To find a potential clinical biomarker capable of monitoring disease activity clinically, quantitative RT-PCR was used to identify transcript expression levels 13 IFIGs peripheral blood cells 144 patients with SLE, 27 non-SLE 60 healthy controls then analyse connections between gene activity. The...
Background Branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential involved in protein synthesis, energy metabolism, immune regulation. While BCAAs known to influence cancer biology, their role leukemia remains unclear. This study employs Mendelian randomization (MR) analysis explore the causal relationship between BCAA levels four subtypes: acute myeloid (AML), lymphoblastic (ALL), chronic lymphocytic (CLL), (CML).
Objective: The therapeutic effect of acid fibroblast growth factor 1(FGF1) on rats with diabetic cardiomyopathy (DCM) was evaluated by using nano-liposomes combined ultrasound-targeted microbubble destruction technique (UTMD). Methods: FGF1-loaded were prepared water-in-water emulsion method lyophilization technique.TypeⅠdiabetes model induced intraperitoneal injection streptozotocin (STZ, 70 mg/kg) in 60 male SD rats.Sixteen weeks later, randomly divided into: placebo group (saline...
Lung cancer ranks first in both incidence and mortality China. The emergence of novel treatments for ALK-positive NSCLC led to an improvement survival quality life patients with advanced ALK mutation-positive non-small cell lung (NSCLC). This study sought assess the cost-effectiveness 6 tyrosine kinase inhibitors (TKIs)-crizotinib, alectinib, ceritinib, brigatinib, ensartinib, lorlatinib-as first-line from perspective Chinese health care system.
BACKGROUND: Gastric cancer (GC) is one of the most common tumors. There were several classifications GC recently. The value Lauren classification in evaluating prognosis after radical gastrectomy was still unclear and gastric remained relatively poor absence prognostic biomarkers. This study aimed to explore microRNA (miRNA) with different classification. METHODS: A retrospective 1144 patients performed this study. Quantificational reverse transcription-PCR (qRT-PCR) used examine expression...
Purpose To assess the potential added value of lung immune prognostic index (LIPI) in patients with small cell cancer (SCLC), treated programmed death-ligand 1 (PD-L1)/programmed death-1 (PD-1) inhibitors, who lived Chinese alpine region. Methods 120 SCLC PD-L1/PD-1 inhibitors were divided into three LIPI groups, from July 2018 to April 2021. Cox regression models used evaluate effect groups on overall survival (OS) and progression-free (PFS). Logistic analysis was conducted explore...
Background Non-small cell lung cancer (NSCLC) with human epidermal growth factor receptor 2 ( HER2 ) alterations poses a substantial treatment challenge. Current -targeted therapies offer limited efficacy. Antibody-drug conjugates (ADCs) targeting have emerged as promising therapeutic strategy. This study aimed to evaluate the clinical response novel ADC drug Disitamab vedotin (RC48) in advanced NSCLC alterations. Methods conducted retrospective review of patients harboring treated RC48 real...
vitamin D plays a crucial role in immune regulation, anti-inflammatory processes, and tumor suppression, but its relationship with leukemia risk remains unclear. This study aims to evaluate the causal between levels of different types through two-sample Mendelian randomization (MR) analysis.
Coronavirus disease 2019 (COVID-19) emergence in late 2019, and wide spread quickly the world. In China, COVID-19 epidemic situation entered a low level now. With arrival of flu season, number patients with respiratory symptoms is increasing. We reported three cases who co-infected SARS-CoV-2 influenza A virus (IAV), they were all treated nirmatrelvir-ritonavir (NMV/r) baloxavir marboxil. Due to overlapping clinical features between two diseases, it important identified them gave antiviral...
<h3>Background</h3> Rheumatoid arthritis (RA) patients can cause joint swelling and tenderness, affect the patient9s mental health. Previous studies showed that 13–47% of RA suffered from anxiety and/or depression. Hospital depression scale (HADS) is usually used to evaluate patients9 health, which consists 14 items divided into an subscale (HADS-A) a (HADS-D). Disease activity score in 28 joints (DAS28) one most tool assess disease activity. Both HADS DAS28 assessments were commonly led by...