A5102021459- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Advanced Radiotherapy Techniques
- RNA modifications and cancer
- Circular RNAs in diseases
- Radiation Dose and Imaging
- Medical Imaging and Analysis
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Retinoids in leukemia and cellular processes
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Synthesis and biological activity
- Galectins and Cancer Biology
- Nanocluster Synthesis and Applications
- Electron Spin Resonance Studies
- Genetic and Kidney Cyst Diseases
- Hippo pathway signaling and YAP/TAZ
- Heme Oxygenase-1 and Carbon Monoxide
- Synthesis and Catalytic Reactions
- Boron Compounds in Chemistry
- Esophageal Cancer Research and Treatment
- Effects of Radiation Exposure
- Chemokine receptors and signaling
Soochow University
2012-2024
First Affiliated Hospital of Soochow University
2012-2024
University of Pittsburgh Medical Center
2022
Nanjing Library
2002
Objective: Cancer stem cells are self-renewal in tumors and can produce heterogeneous tumor cells, which play an important role the development of lung squamous cell carcinoma (LSCC). In our research, we aimed to explore expression genes related LSCC cells.Methods: We downloaded RNAseq data, pathological prognostic profiles cases from public database TCGA. The mRNA expression-based stiffness index (mRNAsi) was calculated value mRNAsi discussed. Then, constructed a weighted gene co-expression...
Radiation treatment for nasopharyngeal carcinoma (NPC) is common and effective. However, local recurrence occurs frequently. Endostar, a novel recombinant human endostatin, an antiangiogenic drug with potent antitumor effect. The present study aimed to observe explore the radiosensitization effects of Endostar on NPC its underlying mechanism. subcutaneous transplantation tumor animal model was established evaluate activity combined radiation (Endostar + radiation) compared monotherapy or...
Abstract Objectives Accurate contouring of the clinical target volume (CTV) is a key element radiotherapy in cervical cancer. We validated novel deep learning (DL)-based auto-segmentation algorithm for CTVs cancer called three-channel adaptive network (TCAS). Methods A total 107 cases were collected and contoured by senior radiation oncologists (ROs). Each case consisted following: (1) contrast-enhanced CT scan positioning, (2) related CTV, (3) multiple plain scans during treatment (4) CTV....
The underlying mechanisms of radiation-induced brain injury are poorly understood, although COX-2 inhibitors have been shown to reduce after irradiation. In the present study, effect celecoxib (a selective inhibitor) pretreatment on rat was studied by means histopathological staining, evaluation integrity blood-brain barrier and detection expressions inflammation-associated genes. protective human microvascular endothelial cells (HBMECs) against irradiation examined potential were explored....
Autosomal-dominant polycystic kidney disease (ADPKD) is a systemic disorder affecting multiple organs that results in renal and extrarenal cysts. Patients with ADPKD may have genomic instability, making them more vulnerable to developing cancer. This study aimed investigate latent instability patients ADPKD, using single-cell gel electrophoresis (comet assay).The susceptibility of peripheral blood lymphocytes DNA damage induced by X-ray treatment (0.5 Gy) was tested 20 electrophoresis. The...
Background CDKL3 has been associated with the prognosis of several tumors. However, potential role in immunotherapy and tumor microenvironment (TME) esophageal carcinoma (ESCA) remains unclear. Methods In this study, Cox regression analysis was used to assess predictive value for ESCA outcomes. We systematically correlated immunological features TME. The predicting efficacy also analyzed. Correlation analysis, LASSO were construct CDKL3-related autophagy (CrA) risk score model. relationship...
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a prevalent cancer with poor survival rate due to anatomical limitations of the head lack reliable biomarkers. Cuproptosis represents novel cellular regulated death pathway, N6-methyladenosine (m6A) most common internal RNA modification in mRNA. They are intricately connected tumor formation, progression, prognosis. This study aimed construct risk model for HNSCC using set mRNAs associated m6A regulators cuproptosis genes...
The focus of this study is the angular dependence two types Metal Oxide Semiconductor Field Effect Transistor (MOSFET) dosimeters (MOSFET20 and OneDose/OneDosePlus) when used for surface dose measurements. External beam radiationat different gantry angles were delivered to a cubic solid water phantom with MOSFET placed on top at CAX. long axis was oriented along rotation, dosimeter (bubble side) facing radiation source. MOSFET-measured doses compared against calibrated radiochromic film...
Abstract Recent evidences show that acylglycerol kinase (AGK) expression is related to the occurrence and development of various human cancers. However, its roles in nasopharyngeal carcinoma (NPC) progression are still unclear. This work aims explore AGK NPC cell stemness. It was shown higher tissues compared adjacent tissues. Online dataset analysis revealed negatively correlated with overall survival patients. Gain loss functional experiments demonstrated positively regulated stemness...
BACKGROUND: Gastric cancer (GC) is one of the most common tumors. There were several classifications GC recently. The value Lauren classification in evaluating prognosis after radical gastrectomy was still unclear and gastric remained relatively poor absence prognostic biomarkers. This study aimed to explore microRNA (miRNA) with different classification. METHODS: A retrospective 1144 patients performed this study. Quantificational reverse transcription-PCR (qRT-PCR) used examine expression...
Postoperative radiotherapy (PORT) is crucial for patients with thoracic locally advanced esophageal squamous cell carcinoma (LA-ESCC, pT3-4aN0-3M0) following esophagectomy. However, the appropriate radiation volume has not been well established. This study aimed to determine optimal PORT LA-ESCC patients.
Radiation enteritis (RE) is a common complication of radiotherapy for abdominal and pelvic tumors, adversely affecting treatment outcomes patients' quality life. Gut microbiome alterations may contribute to RE development, but the underlying pathogenic factors are not fully understood. This study aimed characterize intestinal microbial changes associated with severe acute radiation (SARE) identify predictive biomarkers.
Abstract Objective We investigated the feasibility of deep learning‐based ultra‐low dose kV‐fan‐beam computed tomography (kV‐FBCT) image enhancement algorithm for clinical application in abdominal and pelvic tumor radiotherapy. Methods A total 76 patients tumors were prospectively selected. The Catphan504 was acquired with same conditions as standard phantom test set. used a CycleGAN‐based model enhancement. Normal CT (NDCT), (LDCT) learning enhanced (DLR) evaluated by subjective objective...
Objective To evaluate the effect of Fat Mass and Obesity Associated ( FTO ) gene on radiosensitivity human glioma cell A172 investigate its potential mechanism by changing expression gene. Methods Cells were divided into five groups according to their protein level. The normal group was recorded as Group, low-expression negative control A172/siRNA A172/NC over-expression A172/FTO A172/PC group. expressions assayed Western blot in Group after irradiation. Clonogenic assay executed...
Purpose: In lung radiation treatment, PTV is formed with a margin around GTV (or CTV/ITV). Although most likely of water equivalent density, the may be surrounding low‐density tissues, which lead to unreal dosimetric plan. This study evaluate whether concern dose calculation inside only low density could justified in treatment. Methods: Three SBRT cases were analyzed. The from original plan (Plan‐O) was created 5–10 mm outside ITV incorporate setup errors and all mobility 10 respiratory...