A5100441590- Photoacoustic and Ultrasonic Imaging
- Optical Coherence Tomography Applications
- Nanoplatforms for cancer theranostics
- Advanced Radiotherapy Techniques
- Retinal and Optic Conditions
- Extracellular vesicles in disease
- Ultrasound and Hyperthermia Applications
- Optical Imaging and Spectroscopy Techniques
- Medical Imaging Techniques and Applications
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Thermography and Photoacoustic Techniques
- Advanced X-ray and CT Imaging
- Angiogenesis and VEGF in Cancer
- Ultrasound Imaging and Elastography
- Advanced Fluorescence Microscopy Techniques
- Nuclear Physics and Applications
- Radiomics and Machine Learning in Medical Imaging
- Ultrasonics and Acoustic Wave Propagation
- Solid State Laser Technologies
- Laser Material Processing Techniques
- Radiation Detection and Scintillator Technologies
- Advanced Fiber Laser Technologies
- Flow Measurement and Analysis
- Glaucoma and retinal disorders
Michigan United
2017-2024
University of Michigan
2014-2024
United Imaging Healthcare (China)
2022-2024
Shandong Jianzhu University
2024
Northwestern Polytechnical University
2023
China General Nuclear Power Corporation (China)
2023
Northwest University
2023
Changchun University of Science and Technology
2023
University of Groningen
2022
Southwest Hospital
2022
Abstract Colloidal gold nanoparticles (GNPs) serve as promising contrast agents in photoacoustic (PA) imaging, yet their utility is limited due to absorption peak the visible window overlapping with that of hemoglobin. To overcome such limitation, this report describes an ultrapure chain-like nanoparticle (CGNP) clusters a redshift wavelength at 650 nm. The synthesized CGNP show excellent biocompatibility and photostability. These are conjugated arginine-glycine-aspartic acid (RGD) peptides...
In radiotherapy for cancer patients, an indispensable process is to delineate organs-at-risk (OARs) and tumors. However, it the most time-consuming step as manual delineation always required from radiation oncologists. Herein, we propose a lightweight deep learning framework treatment planning (RTP), named RTP-Net, promote automatic, rapid, precise initialization of whole-body OARs Briefly, implements cascade coarse-to-fine segmentation, with adaptive module both small large organs,...
Photoacoustic microscopy (PAM) is an emerging imaging technology that can non-invasively visualize ocular structures in animal eyes. This report describes integrated multimodality system combines PAM, optical coherence tomography (OCT), and fluorescence (FM) to evaluate angiogenesis larger High-resolution vivo was performed live rabbit eyes with vascular endothelial growth factor (VEGF)-induced retinal neovascularization (RNV). The results demonstrate our RNV both albino pigmented rabbits...
Most reported photoacoustic ocular imaging work to date uses small animals, such as mice and rats, the eyeball sizes of which are less than one-third those humans, posing challenges for clinical translation.Here we developed a novel integrated microscopy (PAM) optical coherence tomography (OCT) system dual-modality chorioretinal larger rabbits.The has quantified lateral resolutions 4.1 µm 3.8 (OCT), axial 37.0 4.0 at focal plane objective.Experimental results in living rabbits demonstrate...
Ionizing radiation acoustic imaging (iRAI) allows online monitoring of radiation's interactions with tissues during therapy, providing real-time, adaptive feedback for cancer treatments. We describe an iRAI volumetric system that enables mapping the three-dimensional (3D) dose distribution in a complex clinical radiotherapy treatment. The method relies on two-dimensional matrix array transducer and matching multi-channel preamplifier board. feasibility temporal 3D accumulation was first...
Multimodal imaging with photoacoustic microscopy (PAM) and optical coherence tomography (OCT) can be an effective method to evaluate the choroidal retinal microvasculature. To improve efficiency for visualizing capillaries, colloidal gold nanoparticles (AuNPs) have been applied as a multimodal contrast agent both OCT PAM by taking advantage of strong scattering absorption AuNPs due their surface plasmon resonance. Ultra-pure were fabricated femtosecond laser ablation, capped polyethylene...
Objective. The goal is to increase the precision of radiation delivery during radiotherapy by tracking movements tumor and other surrounding normal tissues due respiratory body motions. Introduction. This work presents recent advancement X-ray-induced acoustic imaging (xRAI) technology evaluation its feasibility for real-time monitoring geometric morphological misalignments X-ray field with respect target tissue combining xRAI established ultrasound (US) imaging, thereby improving...
Deep Learning (DL) technique has shown great potential but still limited success in online contouring for MR-guided adaptive radiotherapy (MRgART). This study proposed a patient-specific DL auto-segmentation (DLAS) strategy using the patient's previous images and contours to update model improve segmentation accuracy efficiency MRgART.A prototype was trained each patient first set of MRI corresponding as inputs. The updated after fraction with all available fractional MRIs/contours, then...
Abstract Joint high-resolution multimodal photoacoustic microscopy (PAM) and optical coherence tomography (OCT) was developed to improve the efficiency for visualizing newly retinal neovascularization (RNV) monitor dynamic changes of vein occlusion (RVO) in living rabbits. The RNV RVO models were created New Zealand rabbits by Rose Bengal laser-induced RVO. Dual modalities imaging equipment, including color fundus photography, fluorescein angiography (FA), OCT, PAM, used image assess...
Golgi pH homeostasis affects many different biological processes, including glycosylation. Recent studies have demonstrated that transmembrane protein 165 (TMEM165) deficiency leads to glycosylation abnormalities by disturbing homeostasis. However, due the lack of specific tools measure in situ, evidence for TMEM165 involvement H+ transport apparatus is still absent. Herein, photoacoustic and fluorescent dual-mode probe CPH was developed ratiometric detection pH. proved accumulate reversibly...
Although photoacoustic microscopy (PAM) and optical coherence tomography (OCT) allow visualization of the retinal microvasculature, distinguishing early neovascularization from adjacent vessels remains challenging. Herein, gold nanostars (GNSs) functionalized with an RGD peptide were utilized as multimodality contrast agents for both PAM OCT. GNSs have great absorption scattering characteristics in near-infrared region where most vasculature tissue generates a less intrinsic signal while...
The goal of this study is to further develop a multi-modality eye imaging system and evaluate its feasibility acquiring images different modalities simultaneously. An integrated multimodality combining spectral-domain optical coherence tomography (SD-OCT), photoacoustic microscopy (PAM), fluorescence (FM) was developed, performance for validated on multiple clinically-relevant retinal disease models in vivo rabbits. OCT allows visualization the anatomic layers with high axial resolution. PAM...
Visualization and evaluation of choroidal neovascularization (CNV) are major challenges to improve treatment outcomes for patients with age-related macular degeneration (AMD). Limitations current imaging techniques include the limited penetration depth, spatial resolution, sensitivity difficulty visualizing CNV from healthy microvasculature. In this study, a custom-built multimodal photoacoustic microscopy (PAM) optical coherence tomography (OCT) system was developed distinguish margin in...
Stem cell regenerative medicine therapies have emerged as promising treatments for currently incurable diseases. A remaining challenge is the ability to track migration and distribution of transplanted cells in a long-term, noninvasive manner vivo assess their efficacy. This study develops noninvasive, high spatial resolution photoacoustic microscopy (PAM) optical coherence tomography (OCT) imaging system tracking subretinally injected progenitor human retinal pigment epithelium (ARPE-19)...
We present the first endoscopic Doppler optical coherence tomography and co-registered autofluorescence imaging (DOCT-AFI) of peripheral pulmonary nodules vascular networks in vivo using a small 0.9 mm diameter catheter. Using exemplary images from volumetric data sets collected 31 patients during flexible bronchoscopy, we demonstrate how DOCT AFI offer complementary information that may increase ability to locate characterize nodules. offers sensitive visual presentation for rapid...
Photoacoustic ocular imaging is an emerging ophthalmic technology that can noninvasively visualize tissue by converting light energy into sound waves and currently under intensive investigation. However, most reported work to date focused on the of posterior segment eyes small animals, such as rats mice, which poses challenges for clinical human translation due eyeball sizes. This manuscript describes a novel photoacoustic microscopy (PAM) optical coherence tomography (OCT) dual-modality...
Multi-wavelength en face photoacoustic microscopy (PAM) was integrated with a spectral domain optical coherence tomography (SD-OCT) to evaluate properties of retinal vein occlusion (RVO) and neovascularization (RNV) in living rabbits. The multi-wavelength PAM the RVO RNV were performed at several wavelengths ranging from 510 600 nm. Rose Bengal-induced evaluated on eight rabbits using color fundus photography, fluorescein angiography, OCT, spectroscopic PAM. In vivo experiment demonstrates...
Photoacoustic (PA) imaging offers great promise for deep molecular of optical reporters but has difficulties in multiple probes simultaneously a strong blood background. Photoswitchable chromoproteins like BphP1 have recently allowed sensitive PA detection by reducing high-blood background signals lack multiplexing capabilities. We propose method known as difference-spectra demixing photoswitchable and introduce second chromoprotein, sGPC2. sGPC2 far-red orange state with peaks at 700 630...