A5103128948- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Animal Nutrition and Physiology
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- Meat and Animal Product Quality
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Surgical Oncology
- Adipose Tissue and Metabolism
- Brain Metastases and Treatment
- Genetic Mapping and Diversity in Plants and Animals
- Lung Cancer Research Studies
- Molecular Biology Techniques and Applications
- Radiation Therapy and Dosimetry
- Brain Tumor Detection and Classification
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Endometrial and Cervical Cancer Treatments
- MRI in cancer diagnosis
- Electrical and Bioimpedance Tomography
- Ear and Head Tumors
- Peroxisome Proliferator-Activated Receptors
Sun Yat-sen University
2015-2025
Sun Yat-sen University Cancer Center
2015-2025
Hunan Academy of Agricultural Sciences
2011-2024
Hunan Agricultural University
2020-2024
Guangdong Medical College
2024
Hunan City University
2023
Tropical Crops Genetic Resources Institute
2023
Digital Health Cooperative Research Centre
2022
State Key Laboratory of Oncology in South China
2020-2022
Key Laboratory of Guangdong Province
2021-2022
To investigate the feasibility of synthesizing computed tomography (CT) images from magnetic resonance (MR) using generative adversarial networks (GANs) for nasopharyngeal carcinoma (NPC) intensity-modulated radiotherapy (IMRT) planning.Conventional T1-weighted MR and CT were acquired 173 NPC patients. The 28 patients randomly chosen as independent tested set. remaining used to build a conditional GAN (cGAN) cycle-consistency (cycleGAN). A U-net was generator in cGAN, whereas residual-Unet...
Ultrahigh dose-rate irradiation (FLASH-IR) was reported to be efficient in tumor control while reducing normal tissue radiotoxicity. However, the mechanism of such phenomenon is still unclear. Besides, FLASH experiments using high energy X-ray, most common modality clinical radiotherapy, are rarely reported. This study aims investigate radiobiological response 6 MV X-ray FLASH-IR or conventional IR (CONV-IR).The superconducting linac Chengdu THz Free Electron Laser (CTFEL) facility used for...
Abstract Background Shaziling pig is a well-known indigenous breed in China who has superior meat quality traits. However, the genetic mechanism and genomic evidence underlying characteristics of pigs are still unclear. To explore investigate germplasm pigs, we totally analyzed 67 individual’s whole genome sequencing data for first time (20 [S], 20 Dabasha [DBS], 11 Yorkshire [Y], 10 Berkshire [BKX], 5 Basha [BS] 1 Warthog). Results A total 2,538,577 SNPs with high were detected 9 candidate...
MicroRNAs are endogenous, conserved, and non-coding small RNAs that function as post-transcriptional regulators of fat development adipogenesis. Adipogenic marker genes, such CCAAT/enhancer binding protein α (Cebpa), peroxisome proliferator-activated receptor γ (Pparg), adipocyte fatty acid (Ap2), synthase (Fas), regarded the essential transcriptional preadipocyte differentiation lipid storage in mature adipocytes. Canonical Wnt/β-catenin signaling is recognized a negative molecular switch...
This study evaluated the potential of mulberry leaf powder as an unconventional feed material for finishing pigs by assessing growth performance, antioxidative properties, fatty acid profile, and lipid metabolism in 180 Xiangcun black pigs. Pigs with initial body weight (BW) 71.64 ± 1.46 kg were randomly assigned to 5 treatment groups, including control diet 4 experimental diets. The corn, soybean meal, wheat bran partly replaced 3%, 6%, 9%, or 12% There 6 replicates (pens) per replicate...
Deep Learning (DL) technique has shown great potential but still limited success in online contouring for MR-guided adaptive radiotherapy (MRgART). This study proposed a patient-specific DL auto-segmentation (DLAS) strategy using the patient's previous images and contours to update model improve segmentation accuracy efficiency MRgART.A prototype was trained each patient first set of MRI corresponding as inputs. The updated after fraction with all available fractional MRIs/contours, then...
Abstract This study was conducted to evaluate the effect of mulberry leaves as an alternative source protein on growth performance, carcass traits and meat quality in finishing pigs. A total 180 Xiangcun Black pigs were randomly assigned five treatment groups with six pens per pen. The provided a basal diet or contained 3%, 6%, 9% 12% leaf powder during 50‐day experiment period. results showed that dietary had no negative performance pigs, except group, where final body weight average daily...
The effect of dietary supplementation flavonoids from mulberry leaves (FML) on the growth, carcass traits, meat quality, serum antioxidative parameters, and fatty acid profile lipid metabolism skeletal muscle in finishing pigs were investigated present study. A total 120 crossbred F1 barrows Berkshire Bama mini-pig with an average initial body weight (BW) 45.11 ± 4.23 kg randomly assigned to one five treatment groups. Each group consisted six replicates (pens) four per pen. fed either a...
Purpose To develop an advanced deep convolutional neural network (DCNN) architecture to generate synthetic CT (SCT) images from MR for intensity-modulated proton therapy (IMPT) treatment planning of nasopharyngeal cancer (NPC) patients.Methods T1-weighted and paired (PCT) were obtained 206 NPC patients. For each patient, deformable image registration was performed between PCT create MR-CT pair. Thirty pairs randomly chosen as the independent test set remaining 176 (14 validation 162...
This study evaluated the effects of flavonoids from mulberry leaves (FML) on plasma biochemical indices, serum activities lipid metabolism-related enzymes, fat morphology, fatty acid composition, and metabolism in different adipose tissues finishing pigs. We used 120 Chinese hybrid barrows Berkshire Bama mini-pigs with an average initial body weight 45.11 ± 4.23 kg. The pigs were randomly assigned to five treatment groups fed a control diet based corn, soybean meal, wheat bran or...
Purpose: The benefits of additional use nimotuzumab (NTZ) in the treatment locoregionally advanced nasopharyngeal carcinoma (LA-NPC) is largely unclear. We aim to compare LA-NPC outcomes patients that received CCRT with only. Materials and Methods: Between October 2009 January 2012, 31 previously untreated newly diagnosed were administered (3 cycles 100 mg/m2 cisplatin every third week intensity-modulated radiotherapy) plus NTZ according an IRB-approved institutional research protocol. A...
This study was aimed to investigate long-term survivals and toxicities of early-stage nasopharyngeal carcinoma (NPC) in endemic area, evaluating the role chemotherapy stage II patients.Totally 187 patients with newly diagnosed NPC restaged American Joint Committee on Cancer/International Union Against Cancer 8th T1-2N0-1M0 were retrospectively recruited. All received intensity-modulated radiotherapy (IMRT)±chemotherapy (CT) from 2001 2010.With 15.7-year median follow-up, 10-year locoregional...
The aim of this study was to document more appropriate electrode location a four-electrode-based electrical impedance technology in the monitoring bladder filling, and characterize relationship between filling duration measured impedances. A simulation study, based on 2-dimension computational model, conducted determine preferable locations excitation measurement electrodes conventional four-electrode setup. human observation subsequently performed eight healthy volunteers during natural...
Ningxiang pigs exhibit a diverse array of fatty acids, making them an intriguing model for exploring the genetic underpinnings acid metabolism. We conducted genome-wide association study using dataset comprising 50,697 single-nucleotide polymorphisms (SNPs) and samples from over 600 pigs. Our investigation yielded novel candidate genes linked to five saturated acids (SFAs), four monounsaturated (MUFAs), polyunsaturated (PUFAs). Significant associations with SFAs, MUFAs, PUFAs were found 37,...
Abstract Purpose This study aimed to assess the effects of bladder filling during cervical cancer radiotherapy on target volume and organs at risk (OARs) dose based daily computed tomography (daily‐CT) images provide bladder‐volume‐based prediction models. Methods Nineteen patients (475 daily‐CTs) comprised group, five validation set (25 daily‐CTs). Target volumes OARs were delineated daily‐CT treatment plan was recalculated accordingly. The deviation from planning (DVB), correlation between...
Lipids and volatile organic compounds (VOCs) are essential contributors to meat flavor. However, no studies date have comprehensively explored the lipids VOCs in raw pork from Ningxiang (NX) pigs their hybrid breed Berkshire × (BN) pigs. This study aimed identify reveal crucial for characteristic flavor formation. Samples were collected longissimus dorsi muscle of six NX BN 8-month-old each. The intramuscular fat (IMF) content was 5.43%, almost twice that (p < .01). Total 187 significantly...
Objective To evaluate the incidence of hypothyroidism in patients with nasopharyngeal carcinoma after intensity-modulated radiotherapy (IMRT), analyze its correlation multiple influencing factors such as thyroid exposure dose, volume, and gender, construct a multivariate-based normal tissue complication probability (NTCP) model for occurrence IMRT. Materials Methods The hormone levels at different points time before were tested, statistics on treatment obtained. dose-volume data patients’...