A5033626807- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- melanin and skin pigmentation
- Circular RNAs in diseases
- Reproductive System and Pregnancy
- Meat and Animal Product Quality
- Molecular Biology Techniques and Applications
- Nuts composition and effects
- Genetic diversity and population structure
- RNA Research and Splicing
- Animal Genetics and Reproduction
- High Altitude and Hypoxia
- Animal Nutrition and Physiology
- Reproductive Physiology in Livestock
- Peroxisome Proliferator-Activated Receptors
- Hormonal Regulation and Hypertension
- Hair Growth and Disorders
- Hormonal and reproductive studies
- interferon and immune responses
- Prion Diseases and Protein Misfolding
- Probiotics and Fermented Foods
- Wildlife Ecology and Conservation
China Agricultural University
2015-2025
Sanya University
2022-2024
Ministry of Agriculture and Rural Affairs
2023
Ningxia University
2022
Hebei Agricultural University
2022
Hebei University of Engineering
2022
Swedish University of Agricultural Sciences
2005-2009
Uppsala University
2005
Allan Wilson Centre
2005
University of Auckland
2005
Mitochondrial DNA (mtDNA) sequences from 686 wild and domestic pig specimens place the origin of boar in island Southeast Asia (ISEA), where they dispersed across Eurasia. Previous morphological genetic evidence suggested domestication took a limited number locations (principally Near East Far East). In contrast, new data reveal multiple centers Eurasia that European, rather than Eastern, are principal source modern European pigs.
Abstract The domestic dog is becoming an increasingly valuable model species in medical genetics, showing particular promise to advance our understanding of cancer and orthopaedic disease. Here we undertake the largest canine genome-wide association study date, with a panel over 4,200 dogs genotyped at 180,000 markers, accelerate mapping efforts. For complex diseases, identify loci significantly associated hip dysplasia, elbow idiopathic epilepsy, lymphoma, mast cell tumour granulomatous...
Despite having only begun approximately 10,000 years ago, the process of domestication has resulted in a degree phenotypic variation within individual species normally associated with much deeper evolutionary time scales. Though many variable traits found domestic animals are result relatively recent human-mediated selection, uncertainty remains as to whether modern ubiquity long-standing such coat color results from selection or drift, and underlying alleles were present wild ancestor...
Advances in molecular biotechnology have introduced new generations of markers for use the genetic improvement farm animals. Consequently, more accurate information can be obtained to better understand existing animal resources. This review gives a brief summary on development including both classical and advanced DNA-based markers. will help us characteristics different diversity
Mitochondrial DNA (mtDNA) diversity in European and Asian pigs was assessed using 1536 samples representing 45 21 Chinese breeds. Diagnostic nucleotide differences the cytochrome b ( Cytb ) gene between mtDNA variants were determined by pyrosequencing as a rapid screening method. Subsequently, 637 bp of hypervariable control region sequenced to further characterize diversity. All sequences belonged D1 D2 clusters pig originating from ancestral wild boar populations Europe Asia, respectively....
Abstract Background Shaziling pig is a well-known indigenous breed in China who has superior meat quality traits. However, the genetic mechanism and genomic evidence underlying characteristics of pigs are still unclear. To explore investigate germplasm pigs, we totally analyzed 67 individual’s whole genome sequencing data for first time (20 [S], 20 Dabasha [DBS], 11 Yorkshire [Y], 10 Berkshire [BKX], 5 Basha [BS] 1 Warthog). Results A total 2,538,577 SNPs with high were detected 9 candidate...
Tan sheep (Ovis aries), a Chinese indigenous breed, has special curly fleece after birth, especially at one month old. However, this unique phenotype disappears gradually with age and the underlying reasons of trait evolvement are still unknown. In study, skin transcriptome data was used to study issue. total 51,215 transcripts including described transfrags were identified. Pathway analysis top 100 most highly expressed transcripts, which included TCHH keratin gene family members, such as...
In this study, 796 male Duroc pigs were used to identify genomic regions controlling growth traits. Three production traits studied: food conversion ratio, days 100 KG, and average daily gain, using a panel of 39,436 single nucleotide polymorphisms. total, we detected 11 genome-wide 162 chromosome-wide polymorphism trait associations. The Gene ontology analysis identified 14 candidate genes close significant polymorphisms, with growth-related functions: six for KG (WT1, FBXO3, DOCK7, PPP3CA,...
Objective The aim of this study is to identify genomic regions or genes controlling growth traits in pigs. Methods Using a panel 54,148 single nucleotide polymorphisms (SNPs), we performed genome-wide Association (GWA) 562 pure Yorshire pigs with four traits: average daily gain from 30 kg 100 115 kg, and days kg. Fixed random model Circulating Probability Unification method was used the associations between SNPs these traits. SNP annotations were through Sus scrofa data set Ensembl....
The Yunshang Black Goat, a distinguished meat goat breed native to China, is renowned for its superior reproductive capabilities. Despite this, there considerable phenotypic variability within the breed. During cycle, uterus plays pivotal role, with functions evolving in line different stages of cycle. This study focuses on uterine tissues, including both endometrium and myometrium, Goats high fecundity (HF) low (LF) during proliferative (FP) secretory (LP) phases estrous By examining these...
Summary Transmissible spongiform encephalopathy (TSE) is a neurodegenerative disorder in humans and animals. Polymorphisms mutations the prion protein ( PRNP ) gene have been associated with incidence of natural experimental TSE incubation period length. In this study, we determined polymorphisms Chinese ovine, caprine bovine breeds using 400 samples from 13 ovine 250 nine breeds. gene, found five previously unreported amino acid two silent nucleotide alterations. , eight six
Hybridisation among wild mammal populations may lead to introgression of genes and genomes over the species barrier. In Sweden, in northern Europe, on Iberian Peninsula southern mitochondrial DNA from L. timidus occurs europaeus specimens, presumably as a result interspecific hybridisation. Russia, are believed hybridise well, but no investigations have confirmed introgression. Here we develop diagnostic single nucleotide polymorphisms combine them with analysis nuclear microsatellite...
A genetic study of 32 local Chinese, three foreign pig breeds [Duroc (DU), Landrace and Yorkshire], two types wild boar (Hainan Dongbei boar) based on 34 microsatellite loci was carried out to clarify the phylogeny Chinese indigenous breeds. The allele frequencies, effective numbers alleles, average heterozygosity within populations were calculated. results showed that variability Lingao largest, while Jiaxing lowest. greatest distance between domestic pigs found Shanggao DU shortest...
Summary Wild boars from Western Europe have a 2n = 36 karyotype, in contrast to karyotype of 38 wild Central and Asia all domestic pigs. The phylogenetic status this boar population is unclear, it not known if has contributed pig domestication. We now sequenced the mtDNA control region 30 European (22 with confirmed karyotype) six Asian (two Hainan four Dongbei boars) address question. results revealed close genetic relationship between haplotypes those pigs 38. Thus, we cannot exclude...
CircRNAs play an important role in fat deposition, and testosterone-deficient boars exhibit significantly increased deposition; however, the mechanism by which testosterone regulates deposition through circRNAs remains unclear. In this study, circRNA-seq of backfat abdominal from castrated intact full-sib Yorkshire pigs was performed. The GO KEGG enrichment analyses revealed that host genes dorsal DE were mainly involved fatty acid transport, while tissues, these adipogenesis inflammation....
Reproductive traits hold considerable economic importance in pig breeding and production. However, candidate genes underpinning the reproductive are still poorly identified. In present study, we executed a genome-wide association study (GWAS) runs of homozygosity (ROH) analysis using PorcineSNP50 BeadChip array for 585 Yorkshire pigs. Results from GWAS identified two significant eighteen suggestive single nucleotide polymorphisms (SNPs) associated with seven traits. Furthermore, genes,...
Abstract Background It is widely known that castration has a significant effect on the accumulation of adipose tissue. microRNAs (miRNAs) are to be involved in fat deposition and regulated by androgen-induced androgen receptor ( AR ). However, there little understanding relationship between miRNAs after castration. In this study, high-throughput SOLiD sequencing approach was used identify characterize miRNA expression backfat from intact castrated full-sib male 23-week-old pigs. The patterns...
Castration of male pigs is a common practice used to reduce boar taint in commercial pork production, but it also significantly results fat accumulation carcass.Our previous study revealed miRNA gene, ssc-miR-7134-3p that was implicated adipogenesis.However, the relationship between and deposition due castration unknown.In present study, we observed targets coding sequence (CDS) region MARK4 based on bioinformatics analysis dual-luciferase assays.Experiments using silent mutations...
Meat quality is highly influenced by the kind of muscle fiber, and it can be significantly improved increasing percentage slow-twitch fibers. It still not known which genes control formation fibers or how those process forming in sheep until now. In this study, we used high-throughput RNA sequencing to assess expression profiles coding noncoding RNAs tissue Tan Dorper sheep. To investigate molecular processes involved fibers, collected two different tissues, longissimus dorsi biceps femoris,...
Porcine body length is closely related to meat production, growth, and reproductive performance, thus playing a key role in the profitability of pork industry. Cartilage development critical longitudinal elongation individual vertebrae. This study isolated primary porcine vertebral chondrocytes (PVCs) clarify complex mechanisms elongation. We used transcriptome target energy metabolome technologies confirm crucial genes metabolites PVCs at different differentiation stages (0, 4, 8, 12 days)....
Tan sheep is an indigenous Chinese breed well known for its beautiful curly fleece. One prominent characteristic of this that the degree curliness differs markedly between lambs and adults, but molecular mechanisms regulating shift are still not understood. In study, we identified 49 differentially expressed (DE) microRNAs (miRNAs) at two stages through miRNA-seq, combined data with in our earlier Suppression Subtractive Hybridization cDNA (SSH) library study to elucidate underlying fleece...
The Tibetan chickens ( Gallus gallus ; TBCs) are an indigenous breed found in the Qinghai-Tibet Plateau that well-adapted to a hypoxic environment. As of now, energy metabolism TBCs embryonic brain has been little examined. This study investigated changes during hypoxia, and compared Dwarf Laying Chickens (DLCs), lowland chicken breed, explore underlying mechanisms hypoxia adaptation. We exhibited decreased oxygen consumption rates (OCR) ATP levels as well increased extracellular...
Genetic variations introduced via introgression from Western to Chinese pigs have contributed the performance of breeds in traits such as growth rate and feed conversion efficiency. However, little is known about underlying genomic changes that occurred during types affected by introgression. To address these questions, 525 animals were characterized using an SNP array detect regions had been introgressed European indigenous breeds. The functions genes located also investigated. Our data...