A5090753844- Cell death mechanisms and regulation
- Advancements in Transdermal Drug Delivery
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Bee Products Chemical Analysis
- Circular RNAs in diseases
- interferon and immune responses
- Dermatology and Skin Diseases
- Immune Response and Inflammation
- Anesthesia and Neurotoxicity Research
- RNA Research and Splicing
- Hepatitis C virus research
- Advanced Drug Delivery Systems
- Contact Dermatitis and Allergies
- Graphene and Nanomaterials Applications
- Virus-based gene therapy research
- Effects of Radiation Exposure
- Hepatitis B Virus Studies
- Mitochondrial Function and Pathology
- Cancer Research and Treatments
- Molecular Biology Techniques and Applications
- Nanoparticle-Based Drug Delivery
- IL-33, ST2, and ILC Pathways
Kiel University
2025
Third Xiangya Hospital
2022-2024
Central South University
2022-2024
Shandong University
2021-2024
Hunan Normal University
2024
Chongqing Three Gorges University
2022-2024
Stanford University
2005-2023
University Hospital Schleswig-Holstein
2020
University of Lübeck
2020
Huazhong Agricultural University
2013-2017
The tumor suppressor gene p53 has been implicated in the loss of neuronal viability, but signaling events associated with p53-mediated cell death cortical and hippocampal neurons are not understood. Previous work shown that adenovirus-mediated delivery causes some features typical apoptosis. In present study we determined whether p53-initiated changes viability were dependent on members Bcl-2 family regulators. Primary cultures derived from animals containing Bax (+/+ +/-) or those deficient...
A role for p53-related modulation of neuronal viability has been suggested by the finding that p53 expression is increased in damaged neurons models ischemia and epilepsy. These findings were recently extended with demonstration mice deficient ("knock-out" mice) exhibit almost complete protection from seizure-induced brain injury, whereas wild-type display significant cell loss hippocampus other regions. Because knock-out used latter study expressed a global deficiency all types, it was not...
Bax (a death-promoting member of the bcl-2 gene family), tumor suppressor product p53, and ICE/ced-3-related proteases (caspases) have all been implicated in programmed cell death a wide variety types. However, their roles radiation-induced neuronal are poorly understood. In order to further elucidate molecular mechanisms underlying death, we examined ability ionizing radiation induce primary cultured hippocampal neurons obtained from wild-type, p53-deficient Bax-deficient newborn mice....
Caspases play a pivotal role in neuronal cell death during development and after trophic factor withdrawal. However, the mechanisms regulating caspase activity played by activation response to injury is poorly understood. The tumor suppressor gene p53 has been implicated loss of viability caused excitotoxic DNA damaging agents. In present study we determined if p53-mediated required activation. damage increased both cultured embryonic telencephalic postnatal cortical neurons p53-dependent...
Abstract Background RNaseH2 plays a critical role in removing mis-bounded RNA from the DNA double strand helix1. Absence of results spontaneous double-stranded breaks and cytosolic release dsDNA2. We have previously shown that epithelial deficiency RNaseH2b (H2bΔIEC) leads to p53-dependent stem cell suppression additional p53 intestinal carcinogenesis3. Due central cGAS/STING sensing dsDNA, we aim investigate STING mouse model chronic damage tumor prevention this study. Methods was assessed...
Abstract Background Stimulator of interferon genes (STING) regulates intestinal homeostasis and inflammation by detecting cytoplasmic double-stranded DNA, driving type-1 (IFN) responses.1 The autophagy-related gene ATG16L1, a major risk factor for inflammatory bowel disease (IBD), links to STING overactivation in epithelial cells (IEC), causing via IFN1, NF-κB, TNFα signaling.2 Excessive activity is associated with autoinflammatory disorders1, whereas full-body Sting knockout (Tmem173gt/gt)...
miRNAs play a crucial role in regulating immune responses. However, the effect of miR-124-3p on type 2 inflammation allergic rhinitis (AR) is unclear. We aimed to study regulation AR and mechanisms involved.The direct interaction between IL-4Rα was confirmed through dual-luciferase reporter assay. In vitro splenic lymphocytes from mice peripheral blood mononuclear cells (PBMCs) healthy individuals were cultured treated with mimic/inhibitor. Twenty-four female C57BL/C divided into four...
We have previously shown for B-cell lines that the cyclic AMP response element (CRE) is a major positive regulatory site in bcl-2 promoter. However, role of CRE regulation endogenous expression vivo has not been characterized. used gene targeting to generate knock-in mice which mutated was introduced into promoter region (mutCRE-bcl2 mice). Quantitative chromatin immunoprecipitation assays revealed mutation abolished binding CREB/ATF and CBP transcription factors greatly diminished NF-κB...
Melanin is a kind of dark insoluble pigment that can cause pigmentation and free-radical clearance, inducing melasma, freckles, chloasma, affecting the quality life patients. Due to poor water solubility low safety, absorption poorly water-soluble drugs limited by hinderance skin barrier. Therefore, it necessary develop new, safe, highly efficient improve their transdermal efficiency thus inhibit production melanin. To address these issues, we developed new nicotinamide (NIC)-stabilized...
The pathophysiology of diabetic cardiomyopathy (DCM) is a phenomenon great interest, but its clinical problems have not yet been effectively addressed. Recently, the mechanism ferroptosis in various diseases, including DCM, has attracted widespread attention. Here, we explored role PACS2 DCM through downregulation expression. Cardiomyocytes were treated with high glucose and palmitic acid (HGPA), detection cardiomyocyte iron ions, lipid peroxides, reactive oxygen species (ROS) revealed clear...
Abstract Stress response is tightly linked to meat quality. The current understanding of the intrinsic mechanism deterioration under stress limited. Here, male piglets were randomly assigned cortisol and control groups. Our results showed that when serum level was significantly increased, color at 1 h postmortem, muscle bundle ratio, apoptosis rate, gene expression levels calcium channel cell including SERCA1 , IP3R1 BAX Bcl-2 Caspase-3 notably increased. However, value drip loss 24...
Microneedles are one promising penetration enhancement vehicle to overcome the stratum corneum skin barrier, which hampers of drug nanocrystals by transdermal delivery. In order clarify particle size effect on delivery, 60 nm, 120 and 480 nm curcumin were fabricated incorporated into dissolving hyaluronic acid polysaccharide microneedles. The microneedles showed good mechanical strength with 1.4 N/needle, possessing ability insert skin. passive permeation results that smaller diffused faster...
Zinc finger protein 217 (Zfp217), a member of the krüppel-type zinc family, plays diverse roles in cell differentiation and development mammals. Despite extensive research on functions Zfp217 cancer, pluripotency reprogramming, its physiological adipogenesis remain unknown. Our previous RNA sequencing data suggest involvement adipogenesis. In this study, potential function was investigated through bioinformatics analysis series experiments. The expression found to be gradually upregulated...
Hyaluronidase is clinically used in treating many skin diseases due to its good permeability-promoting effect, which may motivate the diffusion and absorption of drugs. To verify penetration osmotic effect hyaluronidase microneedles, 55 nm-size curcumin nanocrystals were fabricated loaded into microneedles containing tip. Microneedles with bullet shape backing layer 20% PVA + PVP K30 (w/v) showed excellent performance. The able pierce effectively a insert rate 90% demonstrated mechanical...