A5100380270- Genetic factors in colorectal cancer
- RNA and protein synthesis mechanisms
- Lymphoma Diagnosis and Treatment
- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- CNS Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Contact Dermatitis and Allergies
- Colorectal Cancer Treatments and Studies
- Electrospun Nanofibers in Biomedical Applications
- Cancer Mechanisms and Therapy
- Gastrointestinal disorders and treatments
- Bee Products Chemical Analysis
- Nanocluster Synthesis and Applications
- Acute Lymphoblastic Leukemia research
- Nuclear Receptors and Signaling
- Circular RNAs in diseases
- Chronic Lymphocytic Leukemia Research
- Nanocomposite Films for Food Packaging
- Cancer-related molecular mechanisms research
- Automotive and Human Injury Biomechanics
- Helicobacter pylori-related gastroenterology studies
- Aluminum toxicity and tolerance in plants and animals
Handan College
2021-2024
Dongyang People's Hospital
2024
Wenzhou Medical University
2024
Shandong University
2015-2023
Guizhou Academy of Agricultural Sciences
2023
Tea Research Institute
2023
People's Hospital of Xinjiang Uygur Autonomous Region
2023
First Affiliated Hospital of Bengbu Medical College
2022
Union Hospital
2022
Huazhong University of Science and Technology
2022
Multiple myeloma (MM) is a cancer that difficult to be diagnosed and treated. This study aimed identify programmed cell death (PCD)-related molecular subtypes of MM assess their impact on patients' prognosis, immune status, drug sensitivity. We used the ConsensusClusterPlus method classify with prognostically relevant PCD genes from patients screened. A prognostic model nomogram were established applying one-way COX regression analysis LASSO Cox analysis. sensitivity chemotherapeutic agents...
To summarize the clinical and epidemiological characteristics of acute intussusception.This retrospective study included pediatric patients with intussusception admitted to Department Pediatric Surgery, Qilu Hospital (Qingdao), Cheeloo College Medicine, Shandong University, from January 2014 December 2019.A total 402 infants/children were (301 males 101 females) a mean age 2.4 ± 1.5 years (2 months 9 years). Thirty (7.5%) had history cold food intake, diarrhea, upper respiratory infection...
Abstract Tea plants are crops with economic, health and cultural value. Catechin, caffeine theanine the main secondary metabolites of taste. In process germplasm collection, we found a resource in Sandu Aquatic Autonomous County Guizhou (SDT) that possessed significantly different characteristic compared cultivar ‘Qiancha 1’. SDT is rich theobromine theophylline, possesses low levels (−)-epicatechin-3-gallate, (−)-epigallocatechin-3-gallate, content, almost free caffeine. However, research...
Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic inflammation of multiple joints, with disruption joint cartilage. The proliferation synovial fibroblasts in response to factors central the pathogenesis rheumatoid arthritis. Our previous studies showed that 4-HNE may induce intrinsic inflammations activating NF- κ B pathways and lead cell apoptosis. However, molecular mechanisms how activation modulated are not fully understood. Here, present findings...
Objective: Transcription elongation factor 1 (TCERG1) is a nuclear protein consisted of multiple structural domains that plays an important role in regulating the transcription, extension, and splicing regulation RNA polymerase II. However, prognostic immunological TCERG1 human cancer remains unknown. In this study, we analyzed expression gene hepatocellular carcinoma (HCC) patients, its clinical significance, possible value by bioinformatics. Methods: sequencing data clinicopathological...
<h3>Objective:</h3> Lynch syndrome (LS) pre-screening methods remain under-investigated in colorectal cancers (CRCs) Asia. Here, we aimed to systematically investigate LS and comprehensively characterize CRCs. <h3>Methods:</h3> Microsatellite instability (MSI) germline variants of DNA mismatch repair (MMR) genes were examined 406 deficient MMR (dMMR) 250 proficient The genetic differences between sporadic CRCs studied with whole exome sequencing analysis. <h3>Results:</h3> incidence dMMR...
The mismatch repair (MMR) pathway maintains genome integrity by correcting errors such as mismatched base pairs formed during DNA replication. In MMR, Msh2–Msh6, a heterodimeric protein, targets single mismatches and small insertion/deletion loops for repair. By incorporating the fluorescent nucleoside analog 6-methylisoxanthopterin (6-MI) at or adjacent to site probe structural dynamic elements of mismatch, we address how Msh2–Msh6 recognizes these within context matched DNA. Fluorescence...
To elucidate the role of mismatch repair gene Mlh1 in genome instability during fetal stage, spontaneous mutations were studied Mlh1-deficient lacZ-transgenic mouse fetuses. Mutation levels high at 9.5 days post coitum (dpc) and gradually increased embryonic after which they remained unchanged. In addition, that found brain, liver, spleen, small intestine thymus showed similar no statistically significant difference was found. The molecular nature 12.5 dpc fetuses / Mlh1–/– mice their own...
Precursor T-cell acute lymphoblastic leukemia (Pre-T ALL) is a malignant neoplastic disease in which T-cells proliferate the bone marrow. Single-cell sequencing technology could identify characteristic cell types, facilitating study of therapeutic mechanisms Pre-T ALL.
It has been reported that mutations in CDH1 gene are associated with genetic susceptibility to colon, stomach, breast and prostate cancers. Here, an induced pluripotent stem cell (iPSC) line from a patient double primary gastric colon carcinoma carrying germline mutation (c. 1679C > G) was generated. The iPSC had normal karyotype, expressed markers ability generate three germ layers.
To investigate the mutational spectrum in young patients with diffuse large B-cell lymphoma (DLBCL) based on next generation sequencing (NGS), and to provide a basis for in-depth understanding of molecular biological characteristics accurate prognosis DLBCL.From March 2009 2021, 68 DLBCL complete initial diagnosis data from Department Hematology, The People's Hospital Xinjiang Uygur Autonomous Region were retrospectively analyzed, their paraffin-embedded tissues subjected targeted analysis...
DNA mismatch repair systems (MMR) are important in reducing post replicative errors and preventing recombination between homologous sequences. Mismatch is highly conserved most organisms initiated by the MutS homodimer prokaryotes. In eukaryotes, small insertion/deletion loops (IDL), single base pair mismatches recognized homolog Msh2‐Msh6. Prior research our lab others (Marsischky G. T., Lee S., Griffith J., Kolodner R. D. (1999) J.Biol.Chem . 274 : 7200–7206 doi:10.1074/jbc.274.11.7200)...
Surface-enhanced Raman scattering (SERS) is a quick and highly sensitive analytical technique for molecules detection at trace level. Copper as SERS substrate has the advantages of low-cost stability. In this work, we designed characterized an Ag-Cu-based dendritic periodic array substrate. The ordered silver-copper on silicon was fabricated through photolithography electrodeposition. performance structure assessed using rhodamine 6G (R6G) probe molecule concentrations ranging from...
We propose and implement a quantum random number generator chip based on vacuum fluctuation. The with PD is only 5mm×4.6mm in size. When 1550nm, 10mW laser input, the thermo-modulated VOA voltage around 1.257, can achieve balance detection. original data through oscilloscope collection MATLAB processing, SNR 15.34. be used cryptography, simulation calculation, lottery industry, etc.
To investigate the relationship between polymorphism of miR-155 and its target gene MyD88 clinicopathological features diffuse large B-cell lymphoma (DLBCL).135 cases DLBCL patients in our hospital from March 2015 to August 2017 were selected, 90 reactive hyperplasia lymph nodes selected as control group. The relative expression detected two groups, characteristics was analyzed.The significantly higher than that group (P<0.05). mutation rate L265P with wild-type associated lesion location,...